Implication of C-reactive protein in development and prognosis of acute lower limb deep venous thrombosis complicated by malignant tumor / 肿瘤研究与临床

Objective To investigate the implication of C-reactive protein in development and prognosis of acute lower limb deep venous thrombosis (DVT) complicated by malignant tumor.Methods34patients with acute lower limb DVT complicated by malignant tumor(observation group),34 patients with acute lower limb DVT complicated by operation or wound(case control group)and 34 normal volunteers (normal control group) were included in this study.The observation group and case control group were treated with conventional therapy such as thrombolysis and anticoagulation.The serum concentrations of CRP before treatment and 14 days after treatment were detected. Recanalization of lower limb DVT and therapeutic efficacy were compared between observation group and case control group.ResultsThe serum concentrations of CRP in observation group before treatment were significantly higher than those in case control group and normal control group [(47.72±29.88) mg/L vs (30.04±15.84) mg/L and (6.19±2.99) mg/L,F =38.444,P ＜ 0.01].At the 14th day of post-treatment,the serum CRP concentrations in observation group and case control group were significantly lower than those before treatment (P ＜0.05).At the 14th day of post-treatment,the CRP concentrations of observation group and case control groups were significantly decreased,although those of observation group were still significantly higher than those of case control group and normal control [(32.77±19.68) mg/L vs (7.76±7.52) mg/L and (6.19±2.99) mg/L,F =50.087,P ＜ 0.01].However,there was no significant difference between case control group and normal control group on the 14th day of post-treatment (F =1.277,P =0.263).The recanalization rate of observation group at the 14th day of post-treatruent were significantly lower than those in case control group(x2 =7.731,P =0.021).The therapeutic effect rate of observation group at the 14th day of post-treatment were also significantly lower than those in case control group (x2 =6.969,P =0.031).ConclusionCRP may play important roles in occurrence,development and therapeutic effect of acute lower limb DVT complicated by malignant tumor.

Changes in hemodynamics following carotid stent implantation / 中国组织工程研究

Carotid stent implantation effectively improves cerebral blood flow perfusion and blood flow rate of stenotic segment. This method has been considered one of effective methods for treating carotid artery stenosis. Surface tear of the endomembrane and atherosclerotic plaque induced by balloon dilatation,mechanical expansion and carotid sinus draw-off can adjust compliance of the carotid wall,change sensitiveness of carotid artery receptor,cause instability of hemadynamics and defluxion of plaque fragments,lead to hypotension,bradycardia,hypertension and vascular embolism. How to control and reduce occurrence of above-mentioned complications is a main problem in present studies. Stent should be soft,with good lateral bending property,and diameter of the stent should be 1.0-2.0 mm longer than the actual stenosis. Implantation technique should be improved. These can reduce extrusion and cutting action of the atheromatous plaque due to balloon dilatation and stent expansion,and prevent plaque defluxion during implantation. Filter protection device is used to filter tissue debris and to prevent microemboli entering cerebral circulation,which can elevate safety of carotid stent implantation.