RESUMO
Objective@#This study investigated the impact of a single piezocision in the maxillary alveolar process on the speed of tooth movement. The null hypothesis was that the speed of tooth movement will be equal with and without piezocision. @*Methods@#All maxillary molars on one side were moved against the combined incisors in 10 ten-week-old male Wistar rats. Under general anesthesia, a force of 25 cN was applied on either side using a Sentalloy closed coil spring. After placing the orthodontic appliance, vertical corticision was performed using a piezotome under local anesthesia, 2 mm mesial from the mesial root of the first molar on a randomly selected side; the other side served as the control. At the beginning of the treatment, and 2 and 4 weeks later, skull micro-computed tomography was performed. After image reconstruction, the distance between the mesial root of the first molar and the incisive canal, and the length of the mesial root of the first maxillary molar were measured. Moreover, the root resorption score was determined as described by Lu et al. @*Results@#Significantly higher speed of tooth movement was observed on the corticision side; thus, the null hypothesis was rejected. The loss of root length and root resorption score were significantly more pronounced after piezocision than before. A strong correlation was observed between the speed of tooth movement and root resorption on the surgical side, but the control side only showed a weak correlation. @*Conclusions@#Piezocision accelerates orthodontic tooth movement and causes increased root resorption.
RESUMO
Acute hepatitis C is rarely diagnosed due to its predominantly asymptomatic course. However, early treatment results in viral eradication in a high number of patients thus, preventing chronicity. The aim of our study was to describe our experience with patients with acute hepatitis C virus [HCV] infection who presented and followed-up in our liver unit, pointing on treatment strategy, and outcome. Retrospective, descriptive study of 30 patients with acute HCV infection [26 males and 4 females] with a mean age of 32 years. The source of infection was mainly injection drug use in 17/30 [56.7] and medical procedures 6/30 [20%]. Twenty patients [66.6%] were symptomatic. HCV-ribonucleic acid [RNA] was detectable at presentation in 26 [86.7%] patients. The genotype distribution was: 13/26 [50%] genotype 1, 3/26 [11.5%] genotype 2, 8/26 [30.8%] genotype 3 and 2/26 [7.7%] genotype 4. Totally, 9 patients [30%] experienced spontaneous viral eradication. No significant differences could be documented between patients who spontaneously cleared the virus and those who had viral persistence. Thirteen patients [44%] were treated with peginterferon-based regimen. All patients [100%] achieved non-detectable HCV-RNA and had normal serum alanine aminotransferase levels at the end of the treatment. Eleven patients achieved sustained virologic response [SVR], one relapsed and one was lost to follow-up. The overall SVR rate was 84.6%. None of the patients required dose reduction or stopped the treatment due to side effects. In conclusion, early initiation of anti-viral treatment in patients with acute hepatitis C results in high-SVR rates [independently of genotype] and is well-tolerated