RESUMO
This study was conducted to evaluate the diverse findings of endoscopy in patients that might assist in their diagnosis. Celiac disease was of special concern as it is a well known cause of short stature which can be its only presentation. A retrospective review of thirty two [32] records of children referred to the pediatric gastrointestinal clinic in Prince Ali Bin Al-Hussein Hospital in Al-Karak with short stature was done. It was conducted over six month's period. All patients were subjected to full history, physical examination and the following investigations: complete blood count, kidney function test, liver function test, thyroid function test, tissue transglutaminase antibodies and abdominal ultrasound. Upper gastrointestinal endoscopy was done to all patients whom we were not able to reach for a diagnosis, mainly to rule out celiac disease. There were 32 children included in this study, 14 female and 18 male with a mean age of 7.75 years, ranges from 2.5-13 years. Normal gross endoscopy was noticed in the majority of patients [25 patients, 78%], most of them had normal histopathological reports [19 patients, 79%]. Nevertheless, four patients out of 25 [16%] were diagnosed to have celiac disease based on the histopathology report. Abnormal endoscopy was noticed in only six patients out of 32 patients, showing D2 effacement and scalloped folds. Two of them were diagnosed to have celiac in histopathological reports [33%]. One patient only [9%] has the combination of short stature and diarrhea: Five patients were having positive tissue transglutaminase antibodies [15%], but only two of them were proved have celiac disease [40%]. Total number of patients with celiac disease in this study was six [18.75%], regardless of their gross endoscopic appearance.Short stature is a common health problem and a well-known feature of celiac disease which should be excluded to prevent serious and long term complications. Investigations should be performed to rule out organic causes including intestinal biopsy which is the gold standard for diagnosis and should be performed in every child with no apparent endocrine causes
RESUMO
Sacral agenesis, known also as caudal regression syndrome, is a rare congenital abnormality characterized by absence of a variable amount of sacrum, lumbar spine and associated neural elements. It is mostly seen in infants of diabetic mothers. Nearly all patients have genitourinary anomalies, neurogenic bladder being the most common. Other associated anomalies include cardiac, gastrointestinal and orthopedic. Here, we present a rare type of lumbosacral agenesis in an infant of a diabetic mother. It was diagnosed antenatally at 26 weeks of gestation
RESUMO
To show that intravenous immunoglobulin is safe and effective alternative treatment in newborn with iso-immune hemolytic jaundice. This study was carried out in neonatal unit in King Hussein Medical Center [KHMC] and Queen Alia Hospital during two years period of all cases who presented with jaundice either RH or ABO iso-immune jaundice in the first day of life. All patients received phototherapy and intravenous immunoglobulin. There were 91 patients with iso-immune jaundice admitted to the neonatal unit in their first day of life. Eighty five patients out of 91 [93.4%] were due to ABO incompatibility. Six patients out of 91 [6.6%] were due to RH incompatibility. Direct coombs test was positive in all cases of RH incompatibility and in 16 cases of ABO incompatibility. Intravenous immunoglobulin [0.5g/kg] was given to all patients over four hours every 24 hours for three doses. Exchange transfusion was done for one patient only [1%]. Blood transfusion was given for 22 patients out of 91 [24%]. Hospital stay was around 3-4 days in majority of cases. Intravenous immunoglobulin in newborn with ABO or RH hemolytic jaundice is effective in reducing hemolysis, serum bilirubin level and the need for exchange transfusion