Histopathological evaluation of odontogenic keratocysts and radicular cysts in Peshawar

Odontogenic cysts are jaw lesions that may be misdiagnosed due to lack of complete data. Clinical, radiographic and histopathological correlation is required for the diagnosis of these cysts. The study was thus designed to determine frequency and compare the histopathological features of radicular cysts and odontogenic keratocysts in population of Northern Pakistan. The study was conducted at Sardar Begum Dental College and Khyber College of Dentistry, Peshawar. Non-probability, consecutive sampling technique was used to select 70 cases of odontogenic cysts from 190 cystic jaw lesions. Formalin-fixed paraffin-embedded tissue samples of Odontogenic keratocysts [n=22] and radicular cysts [n=48] were retrieved from the archives of Khyber College of Dentistry and Sardar Begum Dental College, Peshawar. Frequencies of the cysts were calculated. These were then evaluated for histopathological variables which included thickness of epithelial lining, keratinization, foamy macrophages, mucous cells, Rushton bodies, cholesterol crystals and haemosiderin. Chi-square test/ Fishers exact test was applied to compare cysts. The data was analyzed using SPSS version 21. Frequency of the radicular cyst and odontogenic keratocyst was 68.5% [48N] and 31.5% [22N] re-spectively. The histopathological features showed presence of mucous cells, vacuolated cells, spongiosis, micro-abscesses, cholesterol crystals, hemosiderin and inflammatory infiltrate. The radicular cyst was the most prevalent in our study 48[68.5%], followed by the odontogenic keratocysts 22[31.5%]. The histopathological features observed in these cysts are comparable with other populations of Pakistan and abroad

Patterns of minor salivary gland tumors in Khyber Pahktunkhwa

Present study was carried out to determine the pattern of minor salivary gland tumors, diagnosed at City Medical Laboratory, Peshawar [Pakistan]. The study was conducted at Sardar Begum Dental College using the Anatomical pathology records of City Medical Laboratory, Peshawar from January 2003 to December 2012 and were analyzed by Statistical Program for Social Sciences version 16. A total of 78 cases were diagnosed as minor salivary gland tumors. Out of these 47 were benign and 31 malignant. The male to female ratio for both benign and malignant tumors was 1:1.7. The mean age was 40.39 years. The most common benign tumor was Pleomorphic adenoma [89.3%] and malignant was Adenoid cystic carcinoma [87.09%]. The hard palate was the most common affected site [57.4% in benign and 32.2% in malignant tumors]. The present study showed a different pattern of occurrence of malignant minor salivary gland tumors among the population of Khyber Pahktunkhwa as compared with the European and American population