Primary malignant melanoma of the uterine cervix treated with radical surgery and adjuvant chemo-radiation using temozolomide and cisplatin: a case report

Primary malignant melanoma of the uterine cervix is a rare neoplasm and the overall prognosis of patients with this disease is very poor. Herein, authors report a case of 45-year-old woman who presented with vaginal bleeding for one months and examination showed an exophytic, 6 cm polypoid blackish-pigmented tumor on the cervix involving vaginal fornix. She underwent abdominal radical hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy and further received adjuvant concurrent chemo-radiation with cisplatin (CDDP) and temozolamide but died 7 months after surgery.

Leukemoid reaction as a “prognostic marker” in breast cancer and review of literature.

Neutrophilic leukocytosis above 50 × 10/l not involving the bone marrow, defines a leukemoid reaction (LR). Although it simulates leukemia, most of the causes are inflammatory and benign. LR has been found to be associated with malignancy which is postulated to be caused by granulocyte colony-stimulating factor (G-CSF) secreted by the tumor cells. A 50 years old woman, presented with high grade infiltrating ductal carcinoma of breast and leukocytosis (60 ×10/ cumm). After completion of MRM, the condition of neutrophilic leukocytosis subsided. After three months, total leukocyte count rose and local relapse of tumor was found. Following that wide excision was done,and the condition of leukocytosis subsided again. In this case the leukemoid reaction was a paraneoplastic reaction which can be view as a potential for prognostic marker.