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1.
Chinese Pediatric Emergency Medicine ; (12): 422-426, 2023.
Artigo em Chinês | WPRIM | ID: wpr-990537

RESUMO

Neuromuscular diseases refer to a class of congenital or acquired diseases mainly involving the spinal cord anterior horn motor cells, peripheral nerves, neuromuscular junction and skeletal muscle.The common symptoms and signs include respiratory failure, skeletal malformations, joint contracture, gait abnormalities and movement disorders, and so on.Children in PICU are in more critical conditions.Early systematic, standardized and individualized rehabilitation training can promote the recovery of neuromuscular function, prevent or reduce complications, reduce the incidence and severity of late limb dysfunction, as well as improve the long-term quality of life of children.This review summarized the rehabilitation training of children with neuromuscular disease in PICU.

2.
Chinese Journal of Rehabilitation Theory and Practice ; (12): 784-787, 2020.
Artigo em Chinês | WPRIM | ID: wpr-905389

RESUMO

Severe brain-injured patients would suffer severe disorders of consciousness for a long time. It is needed to prognose their brain function and outcomes. P300 wave of event-related potentials may feature as long latency and short amplitude in disorders of consciousness, which respond to the residual cognitive function. The dynamic changes of P300 wave amplitude and latency can be used to determine the recovery of cognitive function. The P300 waves induced by special stimulus may help to differentiate the vegetative state from the minimally conscious state.

3.
Chinese Pediatric Emergency Medicine ; (12): 421-425, 2020.
Artigo em Chinês | WPRIM | ID: wpr-864932

RESUMO

Most children with severe neurological diseases will survive through early life support, but that inevitable legacy of varying degrees of neurologic impairment, which will bring burden of economy and spirit to the society and family.Recently, the children′s intensive rehabilitation medicine has been gradually applied to clinic, emphasizing that the early rehabilitation intervention to prevent complications and actively improve functions.The study gave a brief introduction on the common neurological dysfunction, principle of management, therapeutic strategy for children with severe neurological diseases.

4.
Chinese Journal of Applied Clinical Pediatrics ; (24): 1037-1040, 2019.
Artigo em Chinês | WPRIM | ID: wpr-752348

RESUMO

Viral encephalitis(VE),one of important causes of postencephalitic epilepsy,is the common infec-tious disease of central nervous system. Although there are many researches of the clinical features and the medical effects about VE with epilepsy,it is scarce to find relative reports about the epilepsy in the sequelae stage. VE and epi-lepsy can cause heavy economic and psychological burden to the patients themselves,their family and society,so the epidemiology,the clinical feature,the therapy,the prognosis and the current status of follow-up studies of postencepha-litic epilepsy after VE are summarized in order to provide the basis for the follow-up supervision.

5.
Chinese Journal of Applied Clinical Pediatrics ; (24): 1037-1040, 2019.
Artigo em Chinês | WPRIM | ID: wpr-802573

RESUMO

Viral encephalitis(VE), one of important causes of postencephalitic epilepsy, is the common infectious disease of central nervous system.Although there are many researches of the clinical features and the medical effects about VE with epilepsy, it is scarce to find relative reports about the epilepsy in the sequelae stage.VE and epilepsy can cause heavy economic and psychological burden to the patients themselves, their family and society, so the epidemiology, the clinical feature, the therapy, the prognosis and the current status of follow-up studies of postencephalitic epilepsy after VE are summarized in order to provide the basis for the follow-up supervision.

6.
Chinese Journal of Practical Pediatrics ; (12): 617-621, 2019.
Artigo em Chinês | WPRIM | ID: wpr-817902

RESUMO

Autism spectrum disorder(ASD)is a developmental disorder disease,with social interaction and communication disorders,stereotyped behavior and narrow interest. As autism knowledge popularization,more and more autism was intervention,however,more concentrated the youth. Pediatricians should also pay attention to the intervention result and the other life stage.

7.
Chinese Journal of Physical Medicine and Rehabilitation ; (12): 594-598, 2018.
Artigo em Chinês | WPRIM | ID: wpr-711325

RESUMO

Objective To assess the impact of rehabilitation procedures based on the International Classification of Function,Disability and Health for Children and Youth (ICF-CY) on the life quality of children with cerebral palsy.Methods Sixty children with cerebra] palsy were randomly divided into an observation group and a control group,each of 30.The observation group received an assessment of their physical functioning,physical structure,activity participation and environmental factors,as well as family guidance based on the ICF-CY framework.The control group was evaluated and treated according to traditional methods.The experiment lasted two months.Before the treatment,as well as after one and two months,both groups were evaluated using Barthel index (BI) and the parents' satisfaction was assessed.The two groups' family training was also evaluated after two months of treatment.Results The average BI and parent satisfaction scores of the two groups were not significantly different before the intervention.After one and two months,improvement was observed on both measures in both groups,but the observation groups' ratings were higher at both time points.After the 2 months of treatment there was no significant difference between the two groups in terms of physical functioning,but the average scores on family rehabilitation,activity participation and environment factors were all significantly better for the observation group.Conclusion Treatment based on the ICF-CY framework can more effectively improve the participation of children with cerebral palsy,which should have a positive effect on their life quality.

8.
Chinese Journal of Physical Medicine and Rehabilitation ; (12): 247-252, 2018.
Artigo em Chinês | WPRIM | ID: wpr-711289

RESUMO

Objective To explore the effect of the retinoic acid (RA) on the apoptosis of neurons caused by hypoxic ischemic brain damage (HIBD).Methods Seventy-two newborn Sprague-Dawley rats were randomly divided into an RA deficiency (RAD) group,an RA normal (RAN) group and a control group,each of 24.The HIBD model was established in the RAD and RAN groups using Rice's method.The left common carotid artery was exposed,ligated and cut,inducing hypoxia.In the control group the left common carotid artery was exposed without any other treatment.Three and 7 days after the operation,neuron apoptosis in the brain tissue was evaluated using TUNEL staining.The degree of HIBD was quantified using modified neurological severity scores (mNSS) 7,14,21 and 28 days after the operation.Primary neurons were cultured in vitro,and oxygen glucose deprivation (OGD) was induced,then control,OGD and RA+ OGD groups were formed.The gene transcription and the protein activity of retinoic acid receptor alpha (RARcα),GDNF (glial cell line-derived neurotrophic factor) and Caspase-8 were examined with polymerase chain reactions (PCR) and Western blotting.The RA+OGD group was exposed to RA and SiRNA adenovirus,and divided into a silenced group and a negative transfection group according to the infection.Results The average mNSS of the RAD group was significantly higher than that of the RAN group.TUNEL staining showed that the apoptotic cells in the cortex increased from day 3 to 7 after the operation,but significantly more in the RAD group than in the RAN group.The gene transcription and protein activity of RARα and GDNF in the RA+OGD group were significantly higher than in the OGD group,and those of Caspase-8 were significantly lower.The gene transcription and protein activity of RARα and GDNF in the silenced group were significantly lower than in the negative transfection group,while those of Caspase-8 were just the opposite.Conclusion RA can inhibit the apoptosis of primary neurons after HIBD by up-regulating the expression of GDNF and down-regulating that of Caspase-8 via RARα.

9.
Chinese Journal of Rehabilitation Theory and Practice ; (12): 567-571, 2017.
Artigo em Chinês | WPRIM | ID: wpr-608084

RESUMO

Objective To detect kinematics and surface electromyography (sEMG) of upper limbs in normal children and motor-delayed children for clinical assessment. Methods From December, 2015 to June, 2016, twelve healthy children and thirteen children with motor de-velopmental delay less than two years old were analyzed kinematics with Motion Analysis system and sEMG. Results The angle of motion of right shoulder was more in the motor-delayed children than in the normal children (t=2.576, P<0.05). The difference of root mean square values of bilateral triceps brachii was more in the motor-delayed children than in the normal ones (t=2.448, P<0.05). Conclusion Detecting kinematics and sEMG may supply information for early personalized treatment strategy.

10.
Chinese Journal of Schistosomiasis Control ; (6): 669-677, 2017.
Artigo em Chinês | WPRIM | ID: wpr-665527

RESUMO

This report presents the endemic status of schistosomiasis in the People's Republic of China at national level in 2016,and analyzes the data collected from the national schistosomiasis prevention and control system and 454 national schisto-somiasis surveillance sites. Among the 12 provinces(municipality and autonomous region)of endemic of schistosomiasis japoni-ca in P. R. China,5 provinces (municipality and autonomous region),i. e.,Shanghai,Zhejiang,Fujian,Guangdong and Guangxi,had achieved elimination,and 7 provinces of Sichuan,Yunnan,Jiangsu,Hubei,Anhui,Jiangxi and Hunan had achieved transmission control by the end of 2016. There are 451 endemic counties(cities,districts)covering 257 million peo-ple,specifically including 29692 endemic villages of 69.39 million people at risk. Among the 451 endemic counties(cities,dis-tricts),35.25%(159/451),42.35%(191/451)and 22.39%(101/451)reached the criteria of elimination,transmission inter-ruption and transmission control,respectively in 2016. By the end of 2016,it was estimated of 54454 infections of schistosome, decreased by 29.46%compared with 77194 in 2015. No acute schistosomiasis case was reported in 2016. There were 30573 ad-vanced schistosomiasis cases documented in 2016. A total of 8500710 individuals received schistosomiasis examinations and 600 individuals were parasitologically diagnosed,decreased by 83.36%compared with 3606 in 2015. The Oncomelania hupen-sis snail survey was performed in 22140 endemic villages and O. hupensis snails were found in 7106 villages,accounting for 32.109%of the total villages,with 20 newly detected villages with snails. The snail survey covered area of 813963.91 hm2 and snails were found in an area of 235096.04 hm2,including a newly detected area of 1346.48 hm2. No schistosome-infected snails were found in 2016. A total of 881050 bovines were raised in the schistosomiasis endemic area. Of them,510468 bovines re-ceived examinations,resulting in 8 schistosome-infected bovines. There were 147642 schistosomiasis cases receiving drug treat-ment in 2016,with 2303555 individuals undergoing expanded chemotherapy;there were 9 bovines with schistosomiasis receiv-ing drug treatment,with 439857 bovines undergoing expanded chemotherapy;a total of 139483.84 hm2 area with snail control by using molluscicides,with actual molluscicide-treated area of 73941.75 hm2;and 3101.52 hm2 snail habitants were treated by environmental modification. Based on the data from the 454 national schistosomiasis surveillance sites,the mean Schistosoma japonicum infection rate was 0.02% and 0.0078% in humans and bovines,respectively. No schistosome-infected snails were found in all the surveillance sites. The results demonstrate a decline in the endemicity of schistosomiasis in P. R. China com-pared with the level of 2015. However,the distribution area of snails in China is still large and the infection source of schistoso-miasis still exists to some extent in some endemic areas;in some regions,the task to reach the standard of transmission interrup-tion is still arduous. There are still objective factors of epidemic and transmission and risk factors of endemic reversal and re-bound for schistosomiasis. So,further control and effective surveillance as well as accurate prevention and control should be im-plemented to promote the elimination process on schistosomiasis in P. R. China.

11.
Chinese Journal of Rehabilitation Theory and Practice ; (12): 640-644, 2016.
Artigo em Chinês | WPRIM | ID: wpr-924005

RESUMO

@#Objective To study the brain cell injuries and behavioral changes of newborn rats with kernicterus. Methods Twenty-five 5-day-old Sprague-Dawley rats were divided into control group (n=11) and model group (n=14) radomly. The model group was injected with bilirubin solution 10 μg/g in the cisterna magna, while the control group was injected with equal volume of normal saline. The neurobehavioral changes were observed and the body mass were recorded. TUNEL staining was used to check the apoptosis of striatal nerve cells of basal ganglia in the model group (n=3) on the first day after modeling. The remaining rats were assessed by gait analysis and beam-walking test 19 days after birth, and Morris water maze test was performed 30 days after birth. Results The model group showed apparently abnormal neurobehavioral changes, such as clenched fists, opisthotonos and the body mass were significantly lower in the model group than in the control group (F>27.707, P<0.001). TUNEL staining showed striatal nerve cells apoptosis in the model group. For the gait analysis, the step lengths of both hind legs were shorter (t>4.129, P<0.01), and the difference of step length was longer (t=-4.415, P<0.001) in the model group than in the control group, however, there was no significantly difference in the step width between two groups (t=0.462, P=0.649). For the beam-walking test, the score was lower in the model group than in the control group (t=-3.644, P=0.004). For the Morris water maze test, the escape latency was longer (F>6.206, P<0.05), and the number of crossing platform was less (t=3.297, P=0.004) in the model group than in the control group. Conclusion The newborn rats' model of kernicterus showed deficits in multiple motor functions and learning and memory ability, which could be assessed by gait analysis, beam-walk test and Morris water maze test, respectively.

12.
Clinical Medicine of China ; (12): 518-520, 2016.
Artigo em Chinês | WPRIM | ID: wpr-492764

RESUMO

Objective To study the serum immunoglobulin IgG,IgM,IgA and complements C3,C4 level changes in hand foot and mouth disease (HFMD) combined with acute flaccid paralysis (AFP).Methods The cases were divided into three groups in this study,including 30 cases of HFMD,30 cases of HFMD combined with AFP,and 30 cases of healthy(normal control group).Immunoturbidimetric assay was used to test the level changes of IgG,IgM,IgA,and complements C3,C4.Results The IgG,IgA,C3 and C4 in HFMD combined with AFP group were (5.49±1.04) g/L,(0.39±0.27) g/L,(0.65.±0.19) g/L and (0.16.±0.11) g/L respectively,lower than those in HFMD group((7.07± 1.63) g/L,(0.55±0.32) g/L,(0.97.±0.18) g/L,(0.23.±0.09) g/L) and normal control group((9.58±1.42) g/L,(0.81±0.33) g/L,(1.28.±0.25) g/L,(0.34.±0.16) g/L),there were statistically significant differences among groups(F=12.04,1.84,1.65,1.29;P=0.031,0.020,0.018,0.025).However,the expression of IgM in HFMD combined with AFP group was (1.34±0.26) g/L,higher than that in HFMD group((1.02±0.29) g/L) and normal control group ((0.76±0.28) g/L),the difference was statistically significant(F=3.62,P=0.014).Conclusion HFMD combined with AFP exists severe humoral immune dysfunction,which provides a theoretical evidence for the prevention and treatment of HFMD combined with AFP.

13.
Chinese Journal of Rehabilitation Theory and Practice ; (12): 1095-1098, 2015.
Artigo em Inglês | WPRIM | ID: wpr-941615

RESUMO

@#Objective To apply sandplay therapy in cerebral palsy children's parents for the psychological problems. Methods 40 parents of cerebral palsy children were randomly divided into experimental group (n=20) and control group (n=20). The experimental group accepted sandplay therapy once a week for 10 weeks, and the control group without any intervention. All the parents were assessed with Symptoms Check-List 90 (SCL-90), Self-Esteem Scale (SES), compliance questionnaire, Quality of Life Questionnaire-Core 30 (QLQ-C30) before and after the experiment. Results The scores of all the factors of SCL-90 were lower in the experimental group than in the control group (P<0.05), with the higher scores of compliance and self-esteem (P<0.05), and the high quality of life in physical function, role in work and social function (P<0.05) in the experimental group. Conclusion Sandplay therapy can be used to solve the psychological problems of cerebral palsy children's parents, and improve their compliance, self-esteem and quality of life.

14.
Chinese Journal of Rehabilitation Theory and Practice ; (12): 1095-1098, 2015.
Artigo em Chinês | WPRIM | ID: wpr-479126

RESUMO

Objective To apply sandplay therapy in cerebral palsy children's parents for the psychological problems. Methods 40 par-ents of cerebral palsy children were randomly divided into experimental group (n=20) and control group (n=20). The experimental group ac-cepted sandplay therapy once a week for 10 weeks, and the control group without any intervention. All the parents were assessed with Symp-toms Check-List 90 (SCL-90), Self-Esteem Scale (SES), compliance questionnaire, Quality of Life Questionnaire-Core 30 (QLQ-C30) be-fore and after the experiment. Results The scores of all the factors of SCL-90 were lower in the experimental group than in the control group (P<0.05), with the higher scores of compliance and self-esteem (P<0.05), and the high quality of life in physical function, role in work and social function (P<0.05) in the experimental group. Conclusion Sandplay therapy can be used to solve the psychological problems of cere-bral palsy children's parents, and improve their compliance, self-esteem and quality of life.

15.
Journal of Clinical Pediatrics ; (12): 361-363, 2015.
Artigo em Chinês | WPRIM | ID: wpr-465765

RESUMO

ObjectiveTo study the clinical characteristics of the temperature instability in Prader-Willi syndrome (PWS). MethodsThe clinical characteristics of one case of PWS with recurrent fever were retrospectively analyzed.ResultsA 5-month-old boy who had such clinical characteristics as low central muscle tension, sucking weakness, feeding dififculties, cryptorchidism and white skin was diagnosed as PWS by chromosomal microarray analysis and methylation-speciifc PCR. In the course of the disease, the infant presented recurrent fever. The pathogenic bacteria culture and virus antibody detection showed negative, and the treatment of reducing fever, anti-infection and immune support were ineffective.ConclusionsThe cause of the recurrent fever is unknown and central fever is suspected. Whether the temperature instability is the clinical feature of PWS still needs a lot of clinical researches.

16.
Journal of Clinical Pediatrics ; (12): 1084-1088, 2014.
Artigo em Chinês | WPRIM | ID: wpr-473758

RESUMO

Objective To study the gene mutations and clinical features of mandibuloacral dysplasia with type A lipodystrophy (MADA) in a Chinese family. Methods The information of 5 family members including 2 siblings suspected atyp-ical progeria was assembled. Genomic DNA was extracted from peripheral blood of 5 family members, the 12 exons of LMNA gene were ampliifed by PCR and then the PCR products were directly sequenced and analyzed by using Blast software online. The SIFT and PolyPhen-2 software were used to predict the harmfulness of mutations. Results The 2 siblings were clinically diagnosed as MADA. Heterozygous c.1579C>T (p.Arg527Cys) and c.1583C>T (p.Thr528Met) mutations were detected in this family. The father carried c.1583C>T (p.Thr528Met) mutation, the mother carried c.1579C>T (p.Arg527Cys) mutation, and their normal daughter were all heterozygous carriers with c.1583C>T (p.Thr528Met) mutation. Compound heterozygous c.1579C>T (p.Arg527Cys) and c.1583C>T (p.Thr528Met) mutations in 2 siblings led to MADA. The MADA showed an autosomal re-cessive inheritance pattern in this family. Conclusions The 2 siblings with MADA in this family were caused by compound heterozygous mutations in LMNA gene.

17.
Journal of Clinical Pediatrics ; (12): 633-636, 2014.
Artigo em Chinês | WPRIM | ID: wpr-452617

RESUMO

Objective To analysis the long-term retention rate of Levetiraceram (LEV) monotherapy or combination therapy of infant epilepsy. Methods The clinical data of patients with infant epilepsy treated by LEV had been retrospectively analyzed from July 2006 to June 2007. Results Sixty patients with infant epilepsy treated by LEV had been recruited, 20 cases with partial seizures, 19 cases with generalized seizures, 21 cases with epilepsy syndrome. Among them 21 cases was intractable epilepsy. The retention rates of LEV in 6-month, 1-year, 2-year, 3-year and 4-year were 95.5%, 75.0%, 60.0%, 51.7%, and 38.3%. The most common reason for withdrawal was lack of effect (43.2%). COX regression model suggested that duration>1 month (RR=2.91, 95%CI:1.16~7.30) and refractory epilepsy (RR=2.30, 95%CI:1.22~4.32) were risk factors of withdrawal (all P<0.05). After treatment, the seizure frequency signiifcantly reduced compared with baseline (P<0.01). To the end of the follow-up, the efifciency was 100%and the complete remission rate was 69.57%in 23 cases continued treatment. The main side effect were fatigue (56.0%), and sleep increased, irritability, and so on. Conclusions LEV monotherapy or combination therapy has well long-term retention rate, maintains well efifcacy and tolerability in infant epilepsy.

18.
Chinese Journal of Tissue Engineering Research ; (53): 7329-7334, 2013.
Artigo em Chinês | WPRIM | ID: wpr-437993

RESUMO

BACKGROUND:Abnormal gaits are very common in children with cerebral palsy, and how to improve the gait is the focus of rehabilitation therapy. OBJECTIVE:To analyze the biomechanical parameters of gaits in cerebral palsy children and to observe the effects of brace control on the exercise capacity of dyskinetic cerebral palsy children. METHODS:In this paper, we compared the biomechanical parameters of children with cerebral palsy and normal children in the initial process of walking and during walking. Biomechanical parameters in the initial process of walking include spatial and temporal parameters, kinematic and kinetic parameters of the range of motion of the knee and ankle. Biomechanical parameters during walking include spatial and temporal parameters. With the aid of hand brace, dyskinetic cerebral palsy received postural control, gait training, and sling exercise therapy for 3 months. The Gross Motor Function Measure (GMFM-88) assessment and video control were conducted for evaluation of therapeutic efficiency. RESULTS AND CONCLUSION:Biomechanical parameters in the initial process of walking showed significant differences between children with cerebral palsy and normal children except for the peak of ground reaction force at frontal axis with the right foot to start walking. Biomechanical parameters during walking showed that the stance phase and bipedal stance phase were prolonged, while the step length and stride length were shortened in the children with cerebral palsy compared with the normal children. For cerebral palsy children with brace control, the GMFM-88 scores were significantly decreased after treatment, involuntary movements were reduced shown on the video, the neck and body were stable, and life skil s were improved. Children with epilepsy and cognitive impairment or who had imaging changes in the basal ganglia showed a little improvement, and children with dance-athetoid type and dystonia type had a better progress than those with athetoid spasm.

19.
Chinese Journal of Physical Medicine and Rehabilitation ; (12): 433-437, 2013.
Artigo em Chinês | WPRIM | ID: wpr-435114

RESUMO

Objective To investigate the effect of red light on the expression of caspase-8 and caspase-3 mRNA and protein during the acute stage of hypoxic-ischemic brain damage (HIBD) in neonatal rats.Methods Forty-five seven-day-old Sprague-Dawley rats were randomly divided into a sham group,an HIBD model group (model group) and an irradiation group.The rats in the model and irradiation groups were subject to HIBD induced using the Rice-Vannucci method.The irradiation group was treated by irradiation with red light on the forehead immediately after the establishment of the HIBD model for 30 min/d on 3 consecutive days,while the sham group and the model group received no treatment.On the 3rd day after the operation,10 rats from each group were sacrificed by cervical dislocation and the left hippocampus was rapidly isolated and snap-frozen in liquid nitrogen for mRNA and protein examination.Another 5 rats in each group were used for immunofluorescence testing to localize and semi-quantify the expression of caspase-8 and caspase-3.Results In the model group,expression of caspase-8 and caspase-3 mRNA and protein in the left hippocampus was higher than in the sham group on the 3rd day.After red light irradiation,expression of caspase-8 and caspase-3 mRNA and protein decreased significantly in the irradiation group compared with the HIBD group.In the CA 1 region of the hippocampus,the levels of caspase-8 and caspase-3 in the irradiation group were significantly lower than in the model group.Conclusion Red light irradiation can decrease the expression of such apoptosis factors as caspase-8 and caspase-3 in hypoxic-ischemic brain damage at the acute stage and inhibit neural cell apoptosis so as to exert therapeutic effects for hypoxic-ischemic brain damage.

20.
Chinese Journal of Physical Medicine and Rehabilitation ; (12): 438-441, 2013.
Artigo em Chinês | WPRIM | ID: wpr-435080

RESUMO

Objective To explore the therapeutic effects of 660 nm red light on sciatic nerve injury in adult rats.Methods Forty-five adult,male rats were divided into a control group and treatment groups 1,2,3 and 4.Sciatic nerve injury was modeled by crushing the nerve.The treatment groups received irradiation with red light once daily for 21 consecutive days.The power density of red light and irradiation time varied among the groups.The latency and amplitude of compound muscle action potentials (CMAPs) and nerve conductive velocity were examined at different time points.The Sciatic Function Index (SFI) was used to evaluate walking function.Results After 21 days of red light therapy no statistically significant differences were observed between the control group and treatment groups 1 to 4 with regard to the latency or the amplitude of the CMAPs.There was a significant difference between the control group and treatment group 3 in terms of sciatic nerve conduction velocity.The average Sciatic Function Indexes of treatment groups 2,3 were significantly different from that of the control group.Conclusion Red light irradiation can promote recovery after sciatic nerve injury,at least in rats,thereby improving walking function.

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