Linear Dissecting Cellulitis Successfully Treated with Simple Excision / 대한피부과학회지

No abstract available.

Early-onset Androgenetic Alopecia in Korean Patients Showed No Significant Relationship with Medical Comorbidities / 대한피부과학회지

BACKGROUND: Androgenetic alopecia (AGA) is characterized by patterned hair loss that typically develops in the third to fourth decade of life. Recently, several studies have reported that medical comorbidities such as coronary artery disease and metabolic syndrome are related with early-onset (before the age of 36 years) AGA, although many of the findings are controversial. OBJECTIVE: We investigated the medical comorbidities and serologic test results of patients with AGA who were aged less than 36 years, and compared them with age-matched controls. METHODS: The medical records of 810 patients with AGA and 227 control subjects who visited the Dermatology Clinic at Yonsei University Wonju Severance Christian Hospital between 2003 and 2012 were retrospectively reviewed. RESULTS: Patients from the early-onset AGA group and controls showed no statistically significant differences in their medical comorbidities, average results of serologic tests, and probabilities of having abnormal laboratory results, except for aspartate aminotransferase levels. CONCLUSION: We observed no significant relationship between early-onset AGA and medical comorbidities in the Korean population. Further case-control prospective studies are warranted to evaluate the precise relationship.

Early-onset Androgenetic Alopecia in Korean Patients Showed No Significant Relationship with Medical Comorbidities / 대한피부과학회지

BACKGROUND: Androgenetic alopecia (AGA) is characterized by patterned hair loss that typically develops in the third to fourth decade of life. Recently, several studies have reported that medical comorbidities such as coronary artery disease and metabolic syndrome are related with early-onset (before the age of 36 years) AGA, although many of the findings are controversial. OBJECTIVE: We investigated the medical comorbidities and serologic test results of patients with AGA who were aged less than 36 years, and compared them with age-matched controls. METHODS: The medical records of 810 patients with AGA and 227 control subjects who visited the Dermatology Clinic at Yonsei University Wonju Severance Christian Hospital between 2003 and 2012 were retrospectively reviewed. RESULTS: Patients from the early-onset AGA group and controls showed no statistically significant differences in their medical comorbidities, average results of serologic tests, and probabilities of having abnormal laboratory results, except for aspartate aminotransferase levels. CONCLUSION: We observed no significant relationship between early-onset AGA and medical comorbidities in the Korean population. Further case-control prospective studies are warranted to evaluate the precise relationship.

Skin Barrier Function Is Not Impaired and Kallikrein 7 Gene Polymorphism Is Frequently Observed in Korean X-linked Ichthyosis Patients Diagnosed by Fluorescence in Situ Hybridization and Array Comparative Genomic Hybridization

X-linked ichthyosis (XLI) is a recessively inherited ichthyosis. Skin barrier function of XLI patients reported in Western countries presented minimally abnormal or normal. Here, we evaluated the skin barrier properties and a skin barrier-related gene mutation in 16 Korean XLI patients who were diagnosed by fluorescence in situ hybridization and array comparative genomic hybridization analysis. Skin barrier properties were measured, cytokine expression levels in the stratum corneum (SC) were evaluated with the tape stripped specimen from skin surface, and a genetic test was done on blood. XLI patients showed significantly lower SC hydration, but normal basal trans-epidermal water loss and skin surface pH as compared to a healthy control group. Histopathology of ichthyosis epidermis showed no acanthosis, and levels of the pro-inflammatory cytokines in the corneal layer did not differ between control and lesional/non-lesional skin of XLI patients. Among the mutations in filaggrin (FLG), kallikrein 7 (KLK7), and SPINK5 genes, the prevalence of KLK7 gene mutations was significantly higher in XLI patients (50%) than in controls (0%), whereas FLG and SPINK5 prevalence was comparable. Korean XLI patients exhibited unimpaired skin barrier function and frequent association with the KLK7 gene polymorphism, which may differentiate them from Western XLI patients.

Skin Barrier Function Is Not Impaired and Kallikrein 7 Gene Polymorphism Is Frequently Observed in Korean X-linked Ichthyosis Patients Diagnosed by Fluorescence in Situ Hybridization and Array Comparative Genomic Hybridization

X-linked ichthyosis (XLI) is a recessively inherited ichthyosis. Skin barrier function of XLI patients reported in Western countries presented minimally abnormal or normal. Here, we evaluated the skin barrier properties and a skin barrier-related gene mutation in 16 Korean XLI patients who were diagnosed by fluorescence in situ hybridization and array comparative genomic hybridization analysis. Skin barrier properties were measured, cytokine expression levels in the stratum corneum (SC) were evaluated with the tape stripped specimen from skin surface, and a genetic test was done on blood. XLI patients showed significantly lower SC hydration, but normal basal trans-epidermal water loss and skin surface pH as compared to a healthy control group. Histopathology of ichthyosis epidermis showed no acanthosis, and levels of the pro-inflammatory cytokines in the corneal layer did not differ between control and lesional/non-lesional skin of XLI patients. Among the mutations in filaggrin (FLG), kallikrein 7 (KLK7), and SPINK5 genes, the prevalence of KLK7 gene mutations was significantly higher in XLI patients (50%) than in controls (0%), whereas FLG and SPINK5 prevalence was comparable. Korean XLI patients exhibited unimpaired skin barrier function and frequent association with the KLK7 gene polymorphism, which may differentiate them from Western XLI patients.

Acidic Water Bathing Could Be a Safe and Effective Therapeutic Modality for Severe and Refractory Atopic Dermatitis

No abstract available.

Application of Topical Acids Improves Atopic Dermatitis in Murine Model by Enhancement of Skin Barrier Functions Regardless of the Origin of Acids

BACKGROUND: The acidic pH of the stratum corneum (SC) is important for epidermal permeability barrier homeostasis. Acidification of the skin surface has been suggested as a therapeutic strategy for skin disorders such as atopic dermatitis (AD). OBJECTIVE: We performed an animal study to evaluate the usefulness of acidification of SC for inhibition of AD lesions and to find out if the therapeutic effect of vinegar is attributable to its herbal contents, rather than its acidity. METHODS: Five groups of six oxazolone-treated (Ox)-AD mice were treated for three weeks with creams of different acidity: vehicle cream alone (pH 5.5), neutralized vinegar cream (pH 7.4), pH 5.0 vinegar cream, pH 3.5 vinegar cream, and pH 3.5 hydrogen chloride (HCl) cream. Also, we have compared two groups of Ox-AD mice treated with pH 5.5 vehicle cream or pH 5.5 vinegar cream. RESULTS: Ox-AD mice treated with acidic creams exhibited fewer AD-like lesions, had significantly lower eczema scores, decreased basal by transepidermal water loss (TEWL), and increased SC hydration compared to the groups given only vehicle and neutral cream. There was no significant difference between the acidic vinegar and HCl groups. Between the groups treated with vehicle and pH 5.5 vinegar cream, there was no difference in eczema score, basal TEWL and SC hydration. CONCLUSION: Application of topical acids, regardless of their source materials, inhibits the development of AD lesions by maintenance of skin surface pH and skin barrier function in murine model.

Cutaneous Metastases from Prostatic Adenocarcinoma / 대한피부과학회지

No abstract available.

Cutaneous Metastasis of Choriocarcinoma

No abstract available.

Periadnexal Mucin as an Additional Histopathologic Feature of Chronic Eczematous Dermatitis

BACKGROUND: Cutaneous mucinoses are a heterogeneous group of disorders characterized by an abnormal amount of mucin in the skin. However, the pathomechanism of an excessive mucin deposition in the skin is still unknown. Eczematous dermatitis is sub-classified histologically into acute, subacute, and chronic variants. The characteristic histopathologic findings for chronic eczema are variable. However, periadnexal mucin deposition is not known as a feature of chronic eczema. OBJECTIVE: To evaluate the presence of periadnexal mucin deposition in chronic eczematous dermatitis. METHODS: We analyzed the skin biopsy specimens from 36 patients who were pathologically diagnosed with chronic eczematous dermatitis. Alcian blue, colloidal iron, and periodic acid-Schiff stains were used to evaluate the mucin deposition in histologic sections. Two dermatologists and two dermatopathologists evaluated the degree of mucin deposition using a 4-point scale. RESULTS: Various amounts of mucin deposition were observed in the periadnexal area of patients who were diagnosed with chronic eczema. Mucin deposition was more visible after staining with mucin-specific stains. Evaluation of the staining analysis scores revealed that the staining intensities were significantly higher in patients with chronic eczema than age- and site-matched controls (normal, acute to subacute eczema, and psoriasis vulgaris). CONCLUSION: Periadnexal mucin (secondary mucinoses) may be an additional finding of chronic eczematous dermatitis.

Differences in Comorbidity Profiles between Early-Onset and Late-Onset Alopecia Areata Patients: A Retrospective Study of 871 Korean Patients

BACKGROUND: Alopecia areata (AA) is a common dermatologic condition with a broad spectrum of clinical features and age of onset, classically characterized by nonscarring patches of hair loss. In the past, early-onset (before adolescence) AA has been associated with various autoimmune diseases, especially atopic diseases and lupus erythematosus and demonstrates a worse prognosis compared with late onset AA. OBJECTIVE: To evaluate the differences in the comorbidity profile of AA with regard to age at onset. METHODS: We completed a retrospective study of 871 Korean AA patients seen at our department within the last 10 years. After these patients were subdivided according to onset before or after age 13 years, the two groups were compared on the basis of their comorbid disorders, family history of AA, and hematologic test results. RESULTS: Our results demonstrate that significantly more patients in the early-onset group had a personal history of atopic dermatitis or family history of AA. These findings are consistent with previous reports associating early-onset AA with autoimmune diseases and a family history of AA in different ethnic populations. Most of the serologic test values showed no significant differences between the groups and the results were considerably affected by age. CONCLUSION: This study is significant because it is a large group study in Korean AA patients, and Korean AA patients with an onset age before adolescence show similar clinical manifestations to other ethnic populations.

Comparison of MAST-CLA System Results between Children and Adults with Atopic Dermatitis (2005~2012, Gangwon, Yeongseo Province) / 대한피부과학회지

BACKGROUND: The multiple allergosorbent test chemiluminescent assay (MAST-CLA) system is a simple method with high sensitivity and specificity for measuring total and allergen-specific IgE antibodies in patients with allergic skin diseases such as atopic dermatitis and urticaria. OBJECTIVE: The purpose of this study was to evaluate total IgE class, allergen frequencies, and their correlations in MAST-CLA in children and adults with atopic dermatitis. METHODS: We performed a retrospective study using medical documents of 2,154 atopic dermatitis patients who visited Yonsei Wonju Severance Christian Hospital between 2005 and 2012. Positive rates of specific IgE and total serum IgE levels in children and adults were analyzed. RESULTS: Among 2,154 total patients, 1,189 (55.2%) were children and 965 (44.8%) were adults. The mean age was 20.2 years. The number of patients with greater than class 2 total serum IgE levels was 1,612 (74.8%), 814 children (68.5%) and 798 adults (82.7%). In total, 1,213 patients (56.3%) showed positive reactions to at least one allergen-specific IgE. The positive rates were 55.5% and 57.3% in children and adults, respectively. The most commonly detected allergen was Dermatophagoides farinae, followed by D. pterony and house dust in both children and adults. Most patients showed lower positive reactions to food allergens. The most common food allergen was white egg in children and shrimp in adults; 35.3% of the patients who showed positive total IgE did not react to any allergen-specific IgE. In addition, 31.4% of patients with negative total IgE showed positive reactions to more than one allergen-specific IgE. The total IgE level and number of positive allergen-specific IgE results showed good correlation in both children and adults. CONCLUSION: According to our results, positive rates of both total IgE and allergen-specific IgE were higher in adults with atopic dermatitis than in children. Both adults and children showed higher positive rates for inhalant allergens. Positive rates for food allergens such as egg whites, milk, and soybean were higher in children. The total IgE level and number of positive allergen-specific IgE results showed good correlation in both groups. MAST-CLA would be a simple and convenient method to determine the causative allergen in atopic dermatitis occurrence and exacerbation, but other studies would be necessary for confirmation.

A Case of Impetigo Herpetiformis with Atypical Skin Manifestation / 대한피부과학회지

Impetigo herpetiformis is a rare and acute pustular eruption that is often accompanied by fever and leukocytosis, which occurs during the 3rd trimester of pregnancy and usually resolves after delivery. In general, impetigo herpetiformis is regarded as a variant of psoriasis that has histopathologic features of pustular psoriasis. The lesions typically begin in the flexural areas, but rarely involve the mucous membranes. The face, palms, and soles are commonly spared. However, we report a 29-year-old woman with impetigo herpetiformis showing mucosal, face and palm involvement, atypical skin manifestation.

Effect of Oral Doxycycline in the Treatment of Korean Early Syphilis Patients / 대한피부과학회지

No abstract available.