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Rev. méd. Chile ; 131(5): 515-519, mayo 2003.
Artigo em Espanhol | LILACS | ID: lil-356109

RESUMO

BACKGROUND: Oropharyngeal candidiasis (OPC) and esophageal candidiasis (EPC) are frequent complications in AIDS patients. The use of Fluconazole, an effective and a low toxicity drug, has been associated to the emergency of secondary resistant strains. For this reason, in vitro antifungal susceptibility tests are necessary to predict a therapeutic failure. Etest is an easy to perform alternative test, that has showed a good agreement with the broth microdilution reference method (NCCLS, document M27-A). AIM: To measure the susceptibility of C. albicans isolates from AIDS patients complicated with OPC and EPC to Amphotericin B (AmB) and Fluconazole (Flu) using Etest. MATERIAL AND METHODS: Twenty strains from 20 AIDS patients were studied. AmB was tested in RPMI 1640 agar and Flu in Casitone agar. RESULTS: All studied strains showed minimal inhibitory concentrations (MICs) < 1 mg/mL for AmB. A highly resistant strain to Flu (> 256 mg/mL) was isolated from a patient previously treated with Flu. CONCLUSIONS: In AIDS patients with OPC and EPC, the susceptibility to Flu of the isolates should be screened, to detect resistant strains. Etest is a reliable alternative in these cases, for laboratories that cannot use the reference method.


Assuntos
Humanos , Masculino , Feminino , Antifúngicos , Candida albicans/efeitos dos fármacos , Candidíase/tratamento farmacológico , Doenças do Esôfago/mortalidade , Infecções Oportunistas Relacionadas com a AIDS/tratamento farmacológico , Antifúngicos , Anfotericina B/farmacologia , Anfotericina B/uso terapêutico , Candida albicans/isolamento & purificação , Candidíase Bucal/tratamento farmacológico , Doenças Faríngeas/tratamento farmacológico , Doenças do Esôfago/complicações , Doenças do Esôfago/tratamento farmacológico , Fluconazol/farmacologia , Fluconazol/uso terapêutico , Infecções Oportunistas Relacionadas com a AIDS/microbiologia , Farmacorresistência Fúngica , Testes de Sensibilidade Microbiana/métodos
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