Hypoglycemic and antioxidant effects of Cleome Droserifolia [Samwah] in alloxan-induced diabetic rats

Diabetes mellitus [DM] is a chronic disease caused by inherited or acquired deficiency in insulin secretion and by decreased responsiveness of the organs to the secreted insulin. Recently, some medicinal plants have been reported to be useful in diabetes treatment. Cleome droserifolia [Samwah] having a long history in Egyptian folk medicine for treatment of diabetes mellitus. The aim of the present study was to evaluate the possible antihyperglycemic property of Cleome droserifolia extract [CDE] and its antioxidant mechanism in alloxan induced diabetic rats. This study was performed on thirty male albino rats of Sprague Dawely strain with an average body weight of 100-110g. Animals were divided into three groups [ten/cage], control untreated group, diabetic group and diabetic group treated with plant extract that was given orally [28.5 mg/kg body wt. twice/ day]. Results showed marked decline in levels of serum insulin, body weight, total proteins, albumin, globulin and high density lipoprotein cholesterol [HDL]. These are accompanied with marked elevation in levels of fasting blood glucose, HOMA-IR, AST, ALT, GGT, urea, creatinine, uric acid, serum total lipids [TL], total cholesterol [TC], triacylglycerols [TG], low density lipoprotein cholesterol [LDL], very low density lipoprotein cholesterol [VLDL] and ratios of TC/HDL and LDL/HDL [risk factors] in diabetic rats as compared to the corresponding controls. While the daily administration of diabetic rats with CDE showed significant amelioration in most of these parameters. It could be concluded that CDE treatment exerts a therapeutic protective nature in diabetes by decreasing oxidative stress and pancreatic beta-cells' damage which may be attributed to its antioxidative potential and antidiabetic property

effects of Jasonia montana [neheda] on some biochemical and histological parameters of diabetic albino rats

Diabetes mellitus is one of the common and widely distributed metabolic diseases all over the world. This disease is characterized by hyperglycemia that results from defects in insulin secretion, insulin action or both. In Asia, different medicinal plant species are used as a traditional treatment for diabetes mellitus e.g. Jasonia montana [Neheda] was one of these plants that was used in a mixture to treat diabetic patients long times ago. This work was aimed to investigate the antidiabetic, hypolipidemic and antioxidant effects of the aqueous extract of Jasonia montana [Neheda] on the alloxan-induced diabetic male albino rats. This study was performed on thirty male albino rats with an average 100-110 g body weight. The animals were divided into three groups [10 /cage]; Group I [Control untreated group], Group II [Alloxan-induced diabetic group] and Group III [diabetic group treated orally with "28.5 mg/ kg body wt. twice/ day" of the plant extract]. The biochemical results showed marked decline [p<0.01] in levels of the serum insulin, body weight, total proteins, albumin, globulin and HDL accompanied with marked elevation [p<0.001] in the levels of fasting blood glucose, levels of HOMA_IR, AST, ALT, GGT, urea, creatinine, uric acid, serum TC, TG, LDL, VLDL and ratios of TC/HDL and LDL/HDL [risk factors] in diabetic rats in comparison with the control group. Daily management of diabetic rates with aqueous extract of Neheda showed significant improvement in most of these parameters. Histologically, considerable improvement in the morphological changes that was observed in diabetic groups had been detected after treatment with Neheda in liver, kidney and pancreatic tissues in comparison to the control group. It could be concluded that Jasonia montana [Neheda] can be used as an antidiabetic drug that can lower blood glucose concentration and guard against the negative effects of diabetes

effects of Ambrosia maritime L. [damsissa] on some biochemical and histological parameters of diabetic albino rats

Diabetes mellitus is one of the common and widely distributed metabolic diseases all over the world. This disease is characterized by hyperglycemia that results from defects in insulin secretion, insulin action or both. Different medicinal plant species are used as a traditional treatment for diabetes mellitus e.g. Ambrosia maritima, L. [Damsissa] which is one of these plants that its extract was used to treat diabetic patients long times ago. This work was aimed to investigate the antidiabetic, hypolipidemic and antioxidant effects of the aqueous extract of Ambrosia maritima, L. [Damsissa] on the alloxan-induced diabetic male albino rats. This study was performed on thirty male albino rats with an average 100-110 g body weight. The animals were divided into three groups [10 /cage]; Group I [Control untreated-group], Group II [Alloxan-induced diabetic group] and Group III [diabetic group treated orally with "28.5 mg/ kg body wt. twice/ day" of the plant extract]. The biochemical results showed marked decline [p<0.01] in the levels of the serum insulin, body weight, total proteins, albumin, globulin and HDL accompanied with marked elevation [p<0.001] in the levels of fasting blood glucose, levels of HOMA_IR, AST, ALT, GGT, urea, creatinine, uric acid, serum TC, TG, LDL, VLDL and ratios of TC/HDL and LDL/HDL [risk factors] in diabetic rats in comparison with the control group. Daily management of the diabetic rates with aqueous extract of Damsissa showed significant improvement in most of these parameters. Histologically, considerable improvement in the morphological changes that was observed in diabetic groups had been detected after treatment with Damsissa in liver, kidney and pancreatic tissues in comparison to the control group. It could be concluded that Ambrosia maritima, L. [Damsissa] can be used as an antidiabetic drug that can lower blood glucose concentration and guard against the negative effects of diabetes

Anti-diabetic effect of Artemisia annua [kaysom] in alloxan-induced diabetic rats

Diabetes is the most common endocrine disorder affecting millions of people worldwide. Nowadays, herbal drugs are gaining popularity in the treatment of diabetes and its complications. The current study was aimed at evaluating the significance of supplementation of Artemisia annua [Kaysom] extract in reducing the metabolic abnormalities accompanied with alloxan-induced diabetes in male albino rats. Thirty male albino rats were divided equally into three groups including control, diabetic and diabetic treated with Kaysom extract. A single dose of alloxan [120 mg/kg body weight] was used to induce diabetes in rats. Diabetic rats were administered Kaysom extract orally twice daily for 30 days. At the end of the experimental period, level of serum fasting insulin and glucose in addition to serum lipids profile such as total cholesterol [TC], triglycerides [TG], high density lipoproteins [HDL], low density lipoproteins [LDL], and very low density lipoproteins[VLDL]; serum proteins including total proteins, albumin and globulin; renal markers [creatinine, urea and uric acid] and activity of certain enzymes such as aspartate aminotransferase [ASAT], alanine aminotransferase [ALAT] and gamma-glutamyltransferase [GGT] was determined for all groups. In. addition, estimation of% change of body weight, values of homeostasis model assessment of insulin resistance [HOMA-IR] and ratios of albumin:globulin [A:G], TC/HDL, LDL/HDL [risk ratios 1 and2] were calculated for each group. Diabetic rats showed a marked decline [p<0.01] in the level of; serum insulin, body weight [4.98%], total proteins, albumin, globulin and HDL accompanied with marked elevation [p<0.01] in level of; fasting blood glucose, HOMA_IR, ASAT, ALAT, GGT, urea, creatinine, uric acid, serum TC, TG, LDL, VLDL and ratios of TC/HDL and LDL/HDL [risk factors] as compared to the corresponding of controls. Supplementation of diabetic rats with Kaysom extract significantly ameliorated most of the estimated biochemical parameters. These results demonstrate that Kaysom extract may be of advantage in inhibiting hyperglycemia and ameliorating metabolic abnormalities induced by diabetes