RESUMO
Background: Preeclampsia is a common obstetrical problem affecting 5-10% of pregnant females. The objective of this study was to determine and compare liver function tests in primigravidas in second and third trimesters of normal pregnancy and preeclampsia
Methods: A cross-sectional comparative study was conducted that included 100 subjects aged 15-40 years with normal pregnancy, and preeclamptic primigravidas of second and third trimester. Their liver function tests were carried out and compared among the study groups
Results: The mean age of the subjects was 25.92+/-5.56 years, mean systolic BP was 136.3+/-24.623 mmHg, mean diastolic blood pressure was 87.8+/-15.736 mmHg. There were statistically significant differences in AST, ALT, ALP, and serum albumin among cases and controls of both 2[nd] and 3[rd] trimester [p<0.05]. However, serum total bilirubin among preeclamptics of 2[nd] and 3[rd] trimesters, and also between controls and preeclamptics of 3[rd] trimester was significantly increased [p<0.05]. Serum AST and ALT were significantly decreased among controls of 3[rd] trimesters compared to 2[nd] trimester while ALP was significantly increased in 3[rd] trimester controls compared to 2[nd] trimester controls. Serum albumin was significantly decreased in both 2[nd] and 3[rd] trimester preeclamptics compared to controls
Conclusion: Serum AST, ALP, and bilirubin was significantly increased in 3[rd] trimester preeclamptics compared to 2[nd] trimester preeclamptics
RESUMO
Background: Pregnant women constitute a high risk group for iron deficiency. Maternal iron deficiency and particularly iron deficiency anaemia may be associated with detrimental effects on maternal and infant function and particularly with a higher risk of preterm delivery and delivery of low birth weight neonates. Objective of this study was to assess and compare the iron status of normal healthy non-pregnant women with that of pregnant women of Hazara Division. Methods: This study was conducted at Faculty of Health Sciences, Hazara University, and Ayub Medical College, Abbottabad from 1st March to 31st August 2006. Altogether 120 women, 90 pregnant at various stages of pregnancy and 30 non-pregnant women as control group were included in this study by convenience sampling. Their iron status was assessed by determination of haemoglobin [Hb], Serum ferritin, Serum-iron, Total Iron Binding Capacity [TIBC], Unsaturated Iron Binding Capacity [UIBC], and Percentage saturation of transferrin. Data generated on these variables were subjected to ANOVA and correlation analysis. Results: The salient finding of this study is a significant decrease in Hb, Serum ferritin, Serum iron, percentage saturation of transferrin and a significant increase in values of TIBC and a pronounced increase in UIBC in 2nd and 3rd trimester compared to 1st trimester in iron deficient pregnant women. The mean values of Hb, SF, and Fe/TIBC% were significantly lower in the cases than in the control and significantly higher values of TIBC and UIBC were observed in the cases compared to controls. Significant correlations were observed for TIBC, UIBC and Fe/TIBC% against serum iron in different trimesters of pregnancy. Conclusion: A high percentage of the pregnant women are iron deficient due to factors such as high parity, poor dietary habits and socioeconomic status