RESUMO
The effect of saline or dextran 70 infusion on the serum albumin level was studied after mild and moderate blood loss. From this experimental study in was shown that infusion of normal saline resulted in a decrease in the albumin level early after infusion than rapid recovery was noticed. Infusion of dextran 70 produced more manifest reduction than normal saline and took longer time to reach to the original value. Decreased albumin concentration caused by dextran infusion could be due to Shifting of albumin into the extravascular compartements [Mornison, 1956] or to the inhibition of synthesis [Craigic et al., 1969] or to the retention of addition fluid within the circulation [Gruber, 1965] or due to failure of Dextran 70 to increase rate of lymph flow [Table III]. The prolonged reduction in the circulating albumin after dextran 70 infusion could be explained by the delayed excretion of dextran 70. Only half the dose given is eliminated by excretion via the kidney within the first 24 hours. The whole given dose takes about 14 days to be elimenated [Artursson et al., 1964]