RESUMO
The analgesic activity of epicoprostanol, the major sterol of ambergris was investigated in male mice, using the hot plate method. Epicoprostanol [1, 10, 100 mg/kg i.p.] significantly increased the hot plate reaction times measured at 60 min post injector. P. chlorophenol alanine which depletes central 5 - HT, only inhibited the antinociceptive activities of 1 and 10 mg epicoprostanol, whereas DSP -4, a neurotoxin of central noradrenergic, the nor adrenergic and serotonergic systems may also be involved in this activity of epicoprostanol
Assuntos
Esteróis/farmacologia , AnalgésicosRESUMO
Ambrein, the major constituent of ambergris, reduced paw oedema in rats induced by carrageenin or serotonin [5-HT], when, it was injected intraperitoneally [i.p.] at a dose of 250 mg/kg. This effect of ambrein was compared with some known antiinflammatory drugs such as hydrocortisone, acetyl-salicylic acid [aspirin] and indomethacin [doses were 40, 350 and 100 mg/kg, i.p. respectively]. The results of this study proved, that ambrein possesses an antiinflammatory activity, which was less potent than that induced by the above antiinflammatory drugs in the carrageenin-induced oedema, but was more potent or, at least, equal in potency, in the 5-HT-induced oedema than those caused by the above antiinftammatory drugs. It is concluded that the antiinflammatory activity of ambrein may be due to inhibition of systemically released 5/HT and/or prostaglandins