Anti-TNF-α and hydralazine drug-induced lupus

Drug-induced lupus is a rare drug reaction featuring the same symptoms as idiopathic lupus erythematosus. Recently, with the introduction of new medicines in clinical practice, an increase in the number of illness-triggering implicated drugs has been reported, with special emphasis on anti-TNF-α drugs. In the up-to-date list, almost one hundred medications have been associated with the occurrence of drug-induced lupus. The authors present two case reports of the illness induced respectively by hydralazine and infliximab, addressing the clinical and laboratorial characteristics, diagnosis, and treatment.

Infarto agudo do miocárdio após uso de anfepramona / Acute myocardial infarction after taking ampherpramone

Relata-se o caso de paciente que sofreu infarto agudo do miocárdio após uso de anfepramona, um análogo da anfetamina. Discutem-se seus efeitos colaterais, mecanismos de lesão e risco - benefício no tratamento da obesidade em relação às doenças cardiovasculares. Conclui-se que o uso dessa droga deve ser feito com cautela e sempre sob orientação médica.