RESUMO
Background. Treatment of Parkinson's Disease (PD) has been attempted by others by transplanting either the patient's own adrenal medullary tissue or fetal substantia nigra into caudate or putamen areas. However, the difficulties inherent in using the patient's own adrenal gland, or the difficulty in obtaining human fetal tissue, has generated the need to find alternative methods. Methods. We report here of an alternative to both procedures by using as transplant metrial cultured human adrenal chromaffin cells differentiated into neuron-like cells by extremely low frequency magnetic fields (ELF MF). Results. The results of this study show that human differentiated chromaffin cells can be grafted into the caudate nucleus of a PD patient, generating substantial clinical improvement, as measured by the unified Rating Scale for PD, which correlated with glucose metabolism and D2 DA receptor increases as seen in a PET scan, while allowing a 70 percent de crease in L-Dopa medication. Discussion. This is the first preliminary report showing that transplants of cultured differentiates neuron-like cells can be successfully used to treat a PD patient
Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Medula Suprarrenal/citologia , Antiparkinsonianos/administração & dosagem , Carbidopa/uso terapêutico , Células Cultivadas/transplante , Cérebro/metabolismo , Células Cromafins , Doença de Parkinson/cirurgia , Dopamina/metabolismo , Glucose/metabolismo , Levodopa/administração & dosagem , Levodopa/uso terapêutico , Magnetismo , Doença de Parkinson , Doença de Parkinson/terapia , Receptores Dopaminérgicos , Tomografia Computadorizada de Emissão , Resultado do TratamentoRESUMO
Se presenta el caso de una paciente de 23 años de edad con leucemi granulocítica crónica en quien se identificaron dos lesiones tumorales con características típicas de meningiomas intracraneales. Durante la cirugía de la masa tumoral de mayor tamaño, que provocaba hipertensión intracraneana, se encontraron todas las características macroscópicas de un meningioma. El tratamiento fue exitoso y el estudio histopatológico reveló un sarcoma granulocítico. La otra masa tumoral fue radiada disminuyendo el volumen tumoral en el término de un mes y dejando a la paciente asintomática desde el punto de vista neurológico. Se propone tratamiento quirúrgico en casos futuros de grandes cloromas