The impact of COVID-19 on acute myeloid leukemia patients undergoing allogeneic stem cell transplantation: a concise review

This study aimed to delineate the possible impact of COVID-19 on acute myeloid leukemia (AML) patients in terms of diagnosis, chemotherapy, bone marrow transplant, and vaccination response. Allogeneic stem cell transplantation is markedly affected by the COVID-19 pandemic, as both donors and recipients must be healthy for transplantation to be feasible and successful. Delays in the identification of well-matched donors have been predicted, and represent a special challenge. Therefore, future donors should be tested for COVID-19. The outcome of delayed transplantation is vague and masked by variations in stem cell source along with disease subtype. However, if transplant delay results in recurrence of minimal residual disease, a negative impact on survival is anticipated.

[ study of the most important bacteria causing urinary tract infections by using bacterial typing device]

The present study was carried out on 175 person were hospitalized into Aleppo University Hospital for the diagnosis of UTI. Urine samples were been taken, and anti-biogram was been carried out. The percentage of the isolated organisms was as follows: Escherichia sp. [32%], Klebsiella sp. [22%], and Enterococcus sp. [14%], Staphylococcus sp. [10%], Pseudomonas sp. [7.5%], Streptococcus sp. [7.5%], and Proteus sp. [7%]. The study has identified the sub-types of bacteria, the results were as follows: - the most frequent sub-type of Escherichia was E. coli [86%]. - The most frequent sub-type of Klebsiella was K. pneumonia [85%]. - The most frequent sub-type of Enterococcus was E. aerogenes [62.5%]. The most frequent sub-type of Streptococcus was S. fecalis [62.5%]. - The most frequent sub-type of Proteus was P.mirabilis [58%]. - The most frequent sub-type of Staphylococcus was S. aureus [55.5%]. - The most frequent sub-type of Pseudomonas was P. aeruginosa-1 [53.8%]

Amniotic fluid and alpha 1 antitrypsin concentration in premature rupture of membranes [PROM]

Alpha - 1 antitrypsin is a natural trypsin inhibitor that is assumed to play a role in preventing PROM. The present study aims at investigating the role of amniotic fluid alpha-1 antitrypsin in PROM. Fifty-seven pregnant women participated in this work. They were classified into 3 groups: Group I comprised 29 pregnant women [30.2 +/- 2.8 weeks] with preterm PROM, group II comprised 18 pregnant women [31.3 +/- 3.2 weeks] with preterm labor but with no PROM and group III comprised 19 pregnant women [34.3 +/- 0.3 weeks] with no preterm labor or PROM. All amniotic fluid samples were obtained by amniocentesis under ultrasound guidance. Amniotic fluid alpha-1 antittypsin was determined by single radial immunodiffusion technique. Amniotic fluid samples were cultured for gram positive and gram negative pathogens.Results of data analysis indicated that amniotic fluid alpha-1 antitrypsin values were significantly lower [P < 0.05] in cases with PROM [9.3 + 10.5 mg/d/] compared with those without PROM, whether having preterm labor [26.9 +/- 8.4 mg/d/] or not [29.8 -15.02 mg/d/]. No significant difference was detected between cases with preterm labor and no PROM and those without either preterm labor or PROM [P > 0.05]. No significant difference was detected between cases with positive cultures [9.94 + 2.39 mg/d/] and those with negative cultures [8.89 +/- 3.38 mg/d/] [P > 0.05]. These data indicate that deficiency of amniotic fluid alpha- 1 antitrypsin may be a major contributor to PROM