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Pakistan Journal of Pharmaceutical Sciences. 2008; 21 (2): 195-199
em Inglês | IMEMR | ID: emr-89413

RESUMO

The occurrence of aggression for prolonged periods of time could have a hazardous impact on the health and social wellbeing of the individual. Aggression can ensue due to exposure to an intimidating situation. Aggression is prominently seen when a disturbance occurs in the fine balance of neurotransmitters such as 5-hydroxytryptamine, gamma- aminobutyric acid, dopamine and their receptor subtypes. The present study investigated the ability of 100 and 200mg/kg of aqueous extract of Eclipta alba to circumvent aggression. Foot shock induced aggression and water competition test were utilized as models for screening of antiaggressive activity. Eclipta alba significantly minimized dominance [p < 0.05] which is correlated to the level of aggression particularly with 200mg/kg in the water competition test. A tangible behavioral submission was observed with 100 and 200mg/kg and of Eclipta alba in the foot shock induced test


Assuntos
Masculino , Feminino , Animais de Laboratório , Agressão/fisiologia , Extratos Vegetais , Ratos Wistar , Camundongos
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