RESUMO
Objective To investigate the disease burden of malignancies in Hangzhou in 2006-2015,and provide information for the prevention and control of cancer.Methods Data regarding deaths due to malignancies in Hangzhou in 2006-2015 was collected from general surveillance information.The main disease burden and population distribution of malignancies were determined by analyzing Potential years of life lost (PYLL),Potential years of life lost rate (PYLLR),standardized potential years of life lost (SPYLL),average years of life lost (AYLL),etc.Results PYLL and SPYLL for overall cancer were 733 811.0 years and 540 794.4 years,respectively,while PYLLR and AYLL were 12.9‰ and 13.1 year/person respectively.The top 5 cancers by PYLL were liver cancer,lung cancer,stomach cancer,colorectal cancer,and leukemia accounting for 67.5％ of overall PYLLR.The disease burden of malignant cancer was higher among male than female subjects.The peak of disease burden occurred in middle-aged and elderly patients.PYLL rate,SPYLL rate,and AYLL from 2011 to 2015 were lower than those from 2006 to 2010,except for cervical cancer.Conclusion Comprehensive control measures should be carried out for the malignancies with a greater burden.
RESUMO
Objective To study the expressions of Toll-like receptor 9 protein (TLR9) in peripheral B and T lymphocytes in newly diagnosed, untreated patients with systemic lupus erythematosus (SLE) and their relationship with clinical parameters. Methods Blood samples were obtained from 35 newly diag-nosed, untreated patients with SLE and 16 healthy human controls. B, T lymphocytes and TLR9 protein were labeled with fluorescent antibodies, and the expressions of TLR9 protein were detected by flow cytometry in peripheral B and T lymphocytes. The relationship between TLR9 expression and clinical parameters was assessed. Results The proportions of B and T lymphocytes expressing TLR9 in newly diagnosed, untreated patients were (53.94±17.95)% and (49.33 ± 23.30)%, respectively, compared to (29.40 ± 10.54)% and (29.18 ± 14.78)%, respectively, in healthy controls (t = 6.11,3.73, respectively, both P < 0.01). Additionally,the proportion of B lymphocytes expressing TLR9 correlated negatively with SLE disease activity index (SLEDAI)(r = -0.39, P < 0.05), but positively with the level of serum IgA antibody (r = 0.74, P < 0.01).Condnsions The expression of TLR9 is elevated in peripheral T and B lymphocytes from patients with newly diagnosed, untreated SLE, and the proportion of TLR9-expressing B lymphocytes negatively correlates with SLEDAI, but positively correlates with the serum level of IgA antibody.