Rehabilitación olfatoria en pacientes laringectomizados: maniobra de inducción del flujo aéreo nasal / Olfactory rehabilitation in laryngectomized patients: nasal airflow inducing maneuver

Resumen Introducción: La laringectomía total (LT) tiene como secuela la perdida de la voz, pero otra consecuencia no estudiada es la pérdida del olfato. Objetivo: Demostrar que la "maniobra de inducción del flujo aéreo nasal" (MIFAN) rehabilita el olfato en pacientes con LT. Material y Método: Estudio cuasiexperimental antes-después en pacientes laringectomizados por cáncer de laringe del Servicio de Otorrinolaringología del Hospital Barros Luco Trudeau (HBLT) de Santiago de Chile. Evaluación a través de encuesta, examen físico, nasofibroscopía y test olfatométrico. Pacientes con alteración del olfato por transmisión serán enrolados y se enseñará la MIFAN. Resultados: Se estudiaron 12 pacientes: 10 hombres, 2 mujeres. Edad promedio 66,3 años, todos autovalentes. 66,6% presentó anosmia y 33,3% hiposmia. Todos lograron realizar la maniobra. Posrehabilitación el 100% presentó presencia de olfato valorada por olfatometría. Población intervenida similar a otras series en cuanto a sexo y edad. La erigmofonación facilita la rehabilitación con MIFAN. La rehabilitación del olfato se logró en todos y paralelamente mejoró el sentido del gusto. Conclusión: La MIFAN es una técnica sencilla, barata y asequible para lograr rehabilitar el sentido del olfato en pacientes laringectomizados.

Abstract Introduction: Total laryngectomy (TL) has as a consequence the loss of voice, but another not studied consequence is the loss of smell. Aim: To demonstrate that the "nasal airflow inducing maneuver" (NAIM) rehabilitates smell in patients with TL. Material and Method: A quasi-experimental before-after study in laryngectomized patients for laryngeal cancer from the Otorhinolaryngology Service (ENT) of the Barros Luco Trudeau Hospital (BLTH) at Santiago, Chile. Evaluation through survey, physical examination, nasofibroscopy and olfactory test. Patients with transmission impairment of smell were enrolled and NAIM was performed. Results: 12 patients were studied: 10 men, 2 women. Average age 66.3 years. All self-supporting. 66.6% presented anosmia and 33.3% hyposmia. They all managed to perform the maneuver. Post-rehabilitation, 100% presented the presence of smell assessed by olfactometry. Intervened population similar to other series in terms of sex and age. Esophageal speech facilitates NAIM rehabilitation. Rehabilitation of smell was achieved in all of them and in parallel, the sense of taste improved. Conclusion: NAIM is a simple, cheap and affordable technique to rehabilitate the sense of smell in laryngectomized patients.

Prevalencia de comorbilidad depresiva en la enfermedad de Ménière

Resumen Introducción: Existe relación entre la enfermedad de Ménière (EM) y los trastornos psiquiátricos. Objetivo: Evaluar si los pacientes con EM presentan mayor prevalencia de comorbilidad depresiva en comparación a lo descrito para la población general nacional. Material y Método: Estudio analítico transversal entre los años 2009-2016, en pacientes del Servicio de Otorrinolaringología del Hospital Barros Luco Trudeau con diagnóstico de EM definitivo. Se aplicó la escala del nivel funcional para EM, tinnitus handicap inventory, test de tamizaje de depresión de Goldberg y una evaluación por psiquiatra. Resultados: Se evaluaron 64 pacientes. Promedio de edad fue 52,5 años. La prevalencia de trastorno depresivo fue 71,8%. De éstos, el 71,7% fue diagnosticado antes del estudio y el 28,3% restante durante el estudio. Conclusión: La prevalencia de comorbilidad depresiva en la EM es mayor que la descrita para la población general nacional. Determinar si la EM es la causante de esta prevalencia, o cada uno de sus síntomas por separado, requerirá de nuevos estudios.

Abstract Introduction: There is a relationship between Ménière's disease (MD) and psychiatric disorders. Aim: To assess whether MD patients have a higher prevalence of depressive comorbidity compared to that described for the national general population. Material and Method: Cross-sectional analytical study between 2009-2016, for patients seen at the Department of Otolaryngology at the Barros Luco Trudeau Hospital with a definitive MD diagnosis. The functional level scale was applied for MD, tinnitus handicap inventory, Goldberg screening for depression, and an evaluation by a psychiatrist. Results: 64 patients were evaluated. Average age was 52.5 years. The prevalence of depressive disorder was 71.8%. Of these, 71.7% were diagnosed before the study and the remaining 28.3% during the study. Conclusion: The prevalence of depressive comorbidity in MD is higher than that described for the national general population. Determine if MD or each symptom separately is the cause of this prevalence requires other studies.

Dolor abdominal agudo / Acute abdominal pain

Acute abdominal pain is one of the most frequent causes of medical consultation in emergency urgent care centers. ER doctors must be capable of recognizing those cases requiring medical treatment and those requiring emergency surgery. Clinical history and physical examination are still the basis for diagnosis, and will guide decisions regarding lab tests and more safe and specific imaging. There are diagnosis such as abdominal pain of unknown origin, gastritis and constipation proven to be associated to error, therefore a stricter follow-up is recommended for these cases. Appendicitis still poses a challenge for diagnosis and if there is clinical suspicion, particularly in young patients and/or women in reproductive age, the recommended approach is ultrasound followed by CT scan (pelvis and abdomen), in case the former is not conclusive. There are special conditions for pregnant and elderly patients regarding imaging tests. During pregnancy, ultrasound and MRI are preferred, whereas CT scan is preferred in case of the elderly, except when biliary disease is suspected, in this case ultrasound is the preferred approach.

El dolor abdominal agudo es una de las causas más frecuentes de consulta a los servicios de urgencia. Los médicos de urgencia deben tener presente su amplio diagnóstico diferencial, y ser capaces de distinguir aquellos casos que requieren un manejo médico o quirúrgico de urgencia. La historia clínica y examen físico siguen siendo las armas fundamentales para el diagnóstico, que guiarán el estudio de laboratorio y la selección de imágenes más segura y de mejor sensibilidad y especificidad. Existen diagnósticos como el dolor abdominal no precisado, gastritis y constipación, que han demostrado estar asociados a error, por lo que se sugiere un seguimiento más estricto en estos casos. La apendicitis sigue siendo un desafío diagnóstico y frente a sospecha clínica, especialmente en jóvenes y/o mujeres en edad fértil, el enfrentamiento diagnóstico con imágenes recomendado es el ultrasonido, seguido de la tomografía computarizada (TC) de abdomen y pelvis, si el primero es no concluyente o negativo. La embarazada y el adulto mayor tienen condiciones especiales, y en cuanto a imágenes, se prefiere el ultrasonido y la resonancia magnética en la primera y la TC precoz en el adulto mayor, excepto cuando hay sospecha de patología biliar donde siempre es de elección el ultrasonido.

Colangiopancreatografía retrograda endoscópica (CPRE) precoz y pancreatitis aguda biliar (PAB) / Early endoscopic retrograde cholangiopancreatography (ERCP) and acute biliary pancreatitis (ABP)

For over 20 years we have discussed the indication of early endoscopic retrograde cholangiopancreatography (ERCP) (72 h before the onset of symptoms) in acute biliary pancreatitis (ABP), seeking to stop the inflammatory process, reducing complications and mortality, taking into account that ERCP can cause pancreatitis and other complications such as perforation and hemorrhage. To elucidate this problem, there have been multiple meta-analyses based on the same 3 or 5 randomized controlled trials of early ERCP versus conventional treatment (including elective ERCP) in ABP, which have produced conflicting results. There is agreement regarding that it is not indicated in mild ABP, and it is indicated in ABP associated with cholangitis and persistent obstruction of the ampulla of Vater. There is controversy in severe presentation of ABP, since current evidence does not definitely show the usefulness of early ERCP. No more complications related to ERCP have been reported in this situation.

Desde hace más de 20 años se discute la indicación de la colangiopancreatografía retrógrada endoscópica (CPRE) precoz (antes de 72 h del inicio de los síntomas) en la pancreatitis aguda biliar (PAB), buscando detener el proceso inflamatorio, disminuyendo sus complicaciones y su mortalidad, tomando en cuenta que la CPRE puede ser causa de pancreatitis y otras complicaciones como perforación y hemorragia. Para dilucidar este problema se han realizado múltiples meta-análisis basados en los mismos 3 ó 5 estudios aleatorizados y controlados de CPRE precoz versus el tratamiento convencional (que incluye CPRE electiva) en PAB, los cuales han dado resultados discordantes. En lo que hay acuerdo es en que no está indicada en la PAB leve y sí está indicada en la PAB asociada a colangitis y a obstrucción persistente de la ampolla de Vater. En la PAB de presentación grave hay controversia; la evidencia actual no demuestra en forma definitiva la utilidad de una CPRE precoz. No se ha reportado mayor número de complicaciones relacionadas a la CPRE en esta situación.

Protocolo prospectivo de pieloplastia laparoscópia pediátrica; del estrés a la tranquilidad / Prospective protocol for laparoscopic pyeloplasty in pediatrics; from stress to tranquility

La resolución quirúrgica de una obstrucción pieloureteral (OPU), con mayor frecuencia se realiza de forma laparoscópica. Siendo un procedimiento difícil per-se, consideramos que para optimizar tiempos, materiales y esfuerzo es necesario involucrar a todo el equipo quirúrgico. Se evalúa protocolo quirúrgico prospectivo, con ajuste de protocolo a mitad del estudio en post de mejorar los tiempos quirúrgicos. Método: Estudio prospectivo de 12 casos de pacientes >5kg con OPU y MA G3 con dificultad de vaciamiento; en quienes se aplicó el protocolo quirúrgico para pieloplastia laparoscópica (pasos quirúrgicos, características de suturas, pig-tail y material quirúrgico). Todos los casos fueron operados por 2 cirujanos con experiencia laparoscópica urológica avanzada (>5 años); un mismo ayudante y dos instrumentistas. Después de los primeros 6 pacientes (grupo A) se analizó y perfeccionó el protocolo quirúrgico, comparando posteriormente resultados y en especial tiempo quirúrgico con los siguientes 6 (grupo B). Resultados: La serie incluyó 9 hombres. La mediana para edad fue de 9.3 meses. El peso promedio fue 16. 7 kg (20.4 vs 13.1 kg respectivamente). En grupo A se realizaron 4 derechas y 2 izquierdas, y el grupo B fue inverso (4 izquierdas). Tres de doce pacientes presentaban OPU secundaria a vasos aberrantes. El tiempo quirúrgico promedio por grupo fue de 171.2 (120-200 min) vs 141.7 (90-210 min) respectivamente. El seguimiento promedio fue 19.6 meses (13-24 meses), todos los pacientes tuvieron buena evolución, con MA G-3 sin obstrucción al vaciamiento y disminución de la hidronefrosis. Conclusiones: Consideramos que la disminución del tiempo quirúrgico en el segundo grupo se debió tanto a la integración del equipo como al perfeccionamiento del protocolo quirúrgico: en la técnica, colocación de un cuarto trocar, forma de colocar pig-tail, tipo y tamaño de suturas, preparación...

Laparoscopic surgical resolution for an ureteropelvic junction obstruction (UPJO) is being widely used around the world. lt is considered as a hard and difficult procedure per-se, we considered for time, materials and effort Optimization; to involve every single member of the surgical team. A surgical protocol was developed and revised, with some adjustments in the middle looking forward to reduce surgical time. Method: Prospective study including 12 patients <5kg weight with UPJO and difficult emptying MA G-3; to whom a surgical protocol for laparoscopic pyeloplasty was applied (surgical steps, suture characteristics, stent and surgical material). All cases were operated by 2 advanced skilled laparoscopic surgeons (>5 year experience); same assistant surgeon and two different surgical assistants. After the first 6 cases (group A) the protocol was revised and improved, comparing results especially surgical time with group B (n=6). Results: The series included 9 male, median ages was 9.3 months. Average weight was 16. 7 kg (20.4 vs 13.1 kg for each group). Four right-sided pyeloplasties and 2 left-sided were performed in group A, and opposite in group B (4 left-side). Three of twelve patients had UPJO secondary to polar vessels. The mean surgical time was 171.2 ( 120-200 min) vs 141. 7 (90-210 min) respective/y. Mean follow-up was 19.6 months (13-24 mo), all patients had good outcome, without obstruction in the MA G-3 study and regression of the hydronephrosis...

Catéteres de hemodiálisis en el paciente <15 Kg: rompiendo paradigmas / Hemodyalisis catheters in patients under 15 Kg: braking paradigma

La instalación de catéteres venosos centrales (CVC) para hemodiálisis es parte de la práctica habitual en los servicios de nefrourologia pediátrica. Sin embargo, aún no existen suficientes reportes sobre resultados exitosos con los catéteres de hemodiálisis (HD) en < 15 kg. Nuestro objetivo es reportar la sobrevida y el desarrollo de complicaciones de los CVC insertados en niños <15 kg y evaluar si su uso es seguro en pediatría. Método: Se realizó un seguimiento prospectivo de los pacientes con enfermedad renal crónica terminal (ERC T), con peso < 15 kg, en quienes se instaló un CVC de hemodiálisis tunelizado por punción, entre julio 2006 y junio 2011. Se analizaron variables como: género, enfermedad de base, edad y peso al inicio de HD, resultado de la HD, sitio de inserción, número de catéteres por paciente, motivo de retiro y tiempo de sobrevida del catéter. Resultados: Durante un periodo de 60 meses, se instalaron 31 CVC en 11 pacientes < 15 kg, 8 hombres y 3 mujeres. La principal causa de ERCT es displasia renal. Al inicio de la HD, la edad promedio de los pacientes fue de 27 meses (5-6om) y la media de peso de 10 kg (4. 5-13 kg). El principal sitio de inserción fue la vena yugular interna (90 por ciento). La duración media de HD fue de 312 días (26-840 días).En promedio se requirieron 2.5 catéteres por paciente (rango 1-5). Los factores mecánicos (trombosis, desplazamiento o acodadura), fueron la principal causa de retiro del catéter (39 por ciento), seguidos por las infecciones (13 por ciento). La sobrevida promedio fue de 110 días/catéter (0 a 586)...

Placement of central venous catheters (C VC) for hemodialysis is part of the usual practice of the pediatric nephron urology services. However, there are few data in the literature documenting successful results with the catheters of hemodialysis (HD) in patients weighing less than 15 kg. Our aim is to report the survival and complications of CVC insertion in children weighing less than 15 kg and to assess whether their use is suitable and safe in low-weight pediatric patients. Methods: Prospective follow-up of patients with end-stage renal disease (ESRD), weighing less than 15 kg, in whom a tunneled hemodialysis CVC was inserted, between July 2006 and June 2011. The following data is gathered: gender, underlying cause of chronic kidney disease, age and weight at the beginning of hemodialysis, catheter location, and duration of HD and reason for discontinuing it, number of catheters used per patient, reasons for removal, and catheter survival. Results: During a period of 60 months, 11 CVC were placed in 31 patients weighing less than 15 kg (8 boys and 3 girls). The main cause of ESRD was renal dysplasia. Mean age at start of dialysis was 27 months (5-60 m) and mean weight was 10 kg (4.5-13 kg). The main catheter location was the internal jugular vein (90 percent). The mean duration of HD was 312 days (26-840 days). An average of 2.5 catheters was required per patient (range 1-5). Mechanical factors (thrombosis, displacement or Layering) were the most common cause of central-line removal (39 percent), followed by infections (13 percent). Mean catheter survival was 110 days/ catheter (range 0-586)...

Diagnóstico y tratamiento de las várices esófago gástricas en Chile: realidad nacional / Management of bleeding esophageal varices in public and private institutions in Chile

Background: The better treatment modalities for bleeding esophageal varices have improved the prognosis of cirrhosis. Aim: To inquire about diagnostic and treatment modalities for esophageal bleeding in Chile. Material and methods: An enquiry about diagnosis and treatment of esophageal bleeding was designed and electronically sent to public and private health institutions that could admit patients and were located in cides with more than 100,000 inhabitants. Results: The enquiry was answered by 31 of 35 public and 17 of 19 private health institutionis that were consulted. Emergency endoscopy was available in 6 of 27 public and in the 16 private institutionis that had an emergency room. Rubber band ligation was available in 16 public (52 percent) and in all private institutions. Cyanoacrylate injections were done in 10 public (32 percent) and 11 (65 percent) private institutions. No public institution installed transjugular intrahepatic portosystemic shunts, but 8 had occasional access to this technique. This procedure was done in 7 (41 percent) private institutions and all had access to it. Surgical treatment was feasible in 20 public (65 percent) and all private institutions. Primary prophylaxis was done in 18 public (58 percent) and 14 private (82 percent) institutions. Secondary prophylaxis was carried out in 26 public (84 percent) and 16 private (94 percent) institutions. Conclusions: Public health institutions have poor access to adequate diagnostic and treatment methods for esophageal bleeding. The primary and secondary prophylaxis of esophageal varices must be improved in both types of institutions.

Dial organic carbon fluctuations in a mangrove tidal creek in Sepetiba bay, Southeast Brazil

The carbon (C) concentration and flux, as dissolved organic carbon (DOC), particulate organic carbon (POC) and macrodetritus (MD), were quantified through 4 tidal cycles in a mangrove tidal creek in Southeastern Brazil. DOC was the major fraction of the total C concentration, accounting for 68 and 61 percent of the total C concentration during ebb and flood periods respectively. Concentrations of DOC (Ebb = 3,41 ± 0,57 mgC.L-1 and Flood = 3,55 ± 0,76 mgC.L-1) and POC (Ebb = 1,73 ± 0,99 mgC.L-1 and Flood = 1,28 ± 0,45 mgC.L-1) were relatively similar during the four tidal cycles. Macrodetritus presented a wide variation with concentration peaks probably related to external forces, such as winds, which enrich the ebb flow with leaf litter. DOC and POC fluxes depended primarily on tidal and net water fluxes, whereas MD fluxes were not. The magnitude of the DOC and POC fluxes varied with the area flooded at high tide, but not the MD fluxes. DOC was the major form of carbon export to Sepetiba Bay. During the four tidal cycles, the forest exported a total of 1,2 kg of organic carbon per ha, mostly as DOC (60 percent), followed by POC (22 percent) and MD (18 percent).

As concentrações e fluxos de carbono orgânico sob forma de carbono orgânico dissolvido (COD), carbono orgânico particulado (COP) e macrodetritos (MD) foram quantificadas durante 4 ciclos de maré em canal de maré na Floresta Experimental de Itacuruçá, Baía de Sepetiba, RJ, litoral sudeste do Brasil. COD foi a fração mais importante para a concentração total de carbono orgânico, contribuindo com 68 e 61 por cento da concentração total de C nos períodos de maré vazante e enchente, respectivamente. As concentrações de COD (vazante = 3.41 ± 0.57 mgC.L-1 e enchente = 3.55 ± 0.76 mgC.L-1) e COP (vazante = 1.73 ± 0.99 mgC.L-1 e enchente = 1.28 ± 0.45 mgC.L-1) foram similares durante os 4 ciclos de maré. A fração macrodetritos apresentou uma ampla variabilidade com máximos de concentração relacionados a fatores externos como ventos, que enriqueceram as águas de vazante com macrodetritos. A magnitude dos fluxos de COD e COP, mas não os de macrodetritos, relacionaram-se com os fluxos de água e a conseqüente área inundada pela maré. A fração COD foi a mais importante forma de exportação de carbono orgânico pelo manguezal. Durante os 4 ciclos monitorados, a floresta exportou um total de 1.2 kg de carbono orgânico, 60 por cento sob forma de COD, seguido pelo COP (22 por cento) e pela fração macrodetritos (18 por cento).

Infección por virus de inmunodeficiencia humana en la embarazada. Importancia del conocimiento de la infección en el embarazo y factores de riesgo en la transmisión perinatal / Human immunodeficiency virus infection in pregnant women. The importance of recognizing the infection during pregnancy and risk factors for perinatal transmission

BACKGROUND: Using adequate infection control measures, the rate of vertical transmission of human immunodeficiency virus (HIV) during pregnancy, has been reduced to 3 per cent in Chile. AIM: To determine vertical transmission rate and risk factors associated to perinatal infection in pregnant women with known (KI) and unknown HIV infection (UI). PATIENTS AND METHODS: HIV infected pregnant women whose deliveries were attended at the San Borja Arriaran Hospital were included. Antiretroviral therapy (ART) has been used since 1995 (Zidovudine 13 patients, biOtherapy 4 and triple therapy 14 patients). Newborns have received ART since 1995. Premature labor without evident cause, premature rupture of membranes, and rupture of membranes over 4 h before delivery were evaluated. Delivery was by elective cesarean section since 1993. Breast feeding was avoided. Pregnant women with UI (suspected disease after delivery due to child or mother pathology) did not received ART. Delivery and breast feeding were managed with common obstetrical-neonatal criteria. RESULTS: Fifty three HIV infected pregnant women were studied (43 with KI and 10 with UI). Four children (36.4 per cent) from the KI group and seven (63.6 per cent from the UI group became infected. The global rate of vertical transmission among KI group was significantly lower than UI group: 9.5 per cent (4/42) vs 70.0 per cent(7/10) p < 0.001. Using ART, this rate was further reduced to 6.5 per cent (2/31) and with bitherapy or triple therapy to 0 per cent (0/18). Breast feeding, vaginal delivery, premature delivery with no clinical cause, premature rupture of membranes, rupture of membranes longer than 4 h and lack of ART, were significantly more common in the UI group, compared with KI group. CONCLUSIONS: Vertical transmission in pregnant women with KI is significantly lower compared with UI. Risk factors increasing HIV perinatal infection are: breast feeding, lack of ART, vaginal delivery, premature rupture of membranes, rupture of membranes > 4 h and premature labor without a clinical cause.

Ligadura elástica complementada de esclerosis en el tratamiento de várices esofágicas: experiencia en la hemorragia activa y en el tratamiento electivo / Endoscopic ligation plus sclerotherapy in the treatment of bleeding esophageal varices

Background: Endoscopic ligation is the treatment of choice for bleeding esophageal varices. The usefulness of additional sclerotherapy is not clear. Aim: To assess the effectiveness of ligation followed by sclerotherapy in the treatment of variceal bleeding. Patients and methods: Forty eight patients with variceal bleeding admitted for emergency treatment and 73 patients admitted for elective treatment were studied. Varices were ligated until a significant reduction in size was achieved. Eradication was completed with the injection of 1 per cent polidocanol. Results: In 34 of 48 patients admitted for emergency treatment, the site of variceal rupture was identified. In all these subjects, and in 13 of 14 patients in whom the rupture site was not identified, hemorrhage was stopped with the procedure. Varices were eradicated in 108 of the 121 patients. Hemorrhage recidivated in 12.5 per cent of patients admitted for emergency treatment, in a period of 14 months of follow up and in 9.6 per cent of those admitted for elective treatment, in a period of 16 months follow up. Mortality was 14, 18 and 57 per cent among patients classified as Child Pugh A, B or C, respectively. Conclusions: Endoscopic ligation is effective in the treatment of variceal bleeding. Adding sclerotherapy, variceal eradication is achieved in a high percentage of patients. Survival depends on hepatic function

Hemorragia por várices esofagogástricas: experiencia con cianoacrilato y polidocanol en 68 pacientes con hemorragia activa / Hemorrhage by esophageal gastric varices: experience with cianoacrylate and polidocanol in 68 patients

Background: Sclerosis, injection of cianoacrylate and rubber band ligation are the most commonly used endoscopic techniques for the treatment of bleeding esophageal varices. Aim: To assess the effectiveness of cianoacrylate and polidocanol in the treatment of bleeding esophageal varices. Patients and methods: Sixty eight patients with active variceal bleeding were studied. Bleeding varices were classified as thin, thick or gastric. Bleeding from thin varices was treated with polidocanol. Bleeding from thick or gastric varices was treated with cianoacrylate. Variceal erradication was done with polidocanol. Results: Bleeding came from thin esophageal varices in 23 percent of patients and endoscopic treatment stopped bleeding in 95 percent of them, from thick esophageal varices in 62 percent and endoscopic treatment was successful in 94 percent of these, and from gastric varices in 12 percent and treatment stopped bleeding in 87 percent of these (in 3 percent bleeding was considered subcardial). Twenty five percent of patients bled again during variceal erradication, 12 percent died due to uncontrollable bleeding and 20 percent died due to liver failure. During variceal erradication 59 percent of patients classified as Child Pugh C, died. Conclusions: Treatment of bleeding esophageal varices with cianoacrylate or polidocanol is effective. Patients classified as Child Pugh C have a bad prognosis