Holy basil (Ocimum sanctum Linn.) leaf extract enhances specific cognitive parameters in healthy adult volunteers: A placebo controlled study.

Introduction: Ocimum sanctum (OS), known as Holy basil, has been documented to possess neuroprotective, cognition-enhancing and stress relieving effects in animal models. However there is paucity of clinical studies to document these effects. Materials and methods: Effect of OS on parameters related to cognition and stress in humans was evaluated with administration of 300 milligram capsules of ethanolic leaf extracts of Ocimum sanctum (EtOS) or placebo per day, over 30 days. Results: Intra-group comparison of Sternberg and Stroop test showed improvement in both the placebo and EtOS groups, however, the improvement stabilized after day 15 in the placebo group. Intergroup comparison revealed a significant improvement of the following cognitive parameters in the EtOS as compared to the placebo: reaction time (RT) and error rate (ER) of Sternberg test, RT of neutral task of Stroop, RT and ER of interference task of Stroop. The intra-group comparison of P300 latency, salivary cortisol, and State-Trait Anxiety Inventory showed improvement over time in the EtOS group alone, though the inter-group difference was significant in the P300 latency alone. There were no changes in heart rate (HR), ΔHR, or galvanic skin response (GSR) or ΔGSR. Conclusion: Ocimum sanctum leaf extract seems to have potential cognition-enhancing properties in humans.

Some explorative information regarding 'Jwaratimirabhăskara' and its author Kăyastha Camunda.

Out of the treasure of Ayurvĕdic literature, a few texts have come in to lime light while some are in dark and available in incomplete form. But many names of the texts with unknown or known authors have been quoted by different subsequent authors in their texts or in the explications by their commentators, for which complete texts are not available at present. Among the texts on specific diseases, one notable work is 'Jwaratimirabhăskara' written by Kăyastha Camunda. Nowhere a detailed account of author's identity, time and place has been mentioned, while short references are available in some historical books. However, manuscripts of this text are available in many repositories of our country. In this article, an attempt has been made to establish the identity of the author, period of the text and also to highlight the salient features of this text.

Important Ayurvĕda literatures from the manuscripts available from Orissa (Cikitsărnava).

In the treasure of Ayurvĕdic literature, many texts are missing or partially available. Only references or few verses from many such texts are mentioned in later texts. Unfortunately, a large number of Ayurvĕdic texts are unexplored till today are likely to exist in palm-leaf manuscripts, which are decaying or undergoing permanent annihilation. As such many unique and valuable information contained in these texts are being lost. Though several Institutions have taken up work on literary Research, only few texts have been published during past decades. The present paper highlights the salient features of the text 'Cikitsărnava' authored by Viśvanăth Sena of 16th century of Orissa. Though his text on Pathyăpathya has already been published, which has got a place in the pages of history of Ayurvĕda, a very little is known about this important text on therapeutics. Various aspects of this text and its author have been discussed to bring it in to the knowledge of fraternity of Ayurvedic physicians and Sanskrit scholars.

Kushtha (skin disorders) in vedic and other religious literatures - A review.

In view of the description of Medical citations; Vedic literature, Buddhist literature, Jain literature, Mahabharat, Ramayan etc. have also got significant importance. Like other diseases, the description regarding Kushtha (different skin disorders) is also available in all these treatises. These are akin to the description available in Ayurveda. From the above, it is apparent that description of different diseases mentioned in Ayurveda are also available in religious literatures.

Screening of Madhumehaghna (anti diabetic) plants in Vrihattrayee.

The three texts written by Charak, Sushrut and Vagbhat are considered as Vrihattrayee because of their original contributions to the basic tenants of Ayurveda and innovative uses of plants and medicine. But despite the possibility of exploring efficacious for mulations from among these classics, not much attempts have been made in this direction, due to the fact that now most of them are not in vogue in practice by majority of Ayurvedic physicians. As such, a glossary of plants as described in those texts for the management of prameha including diabetes has been collected which would be useful for studying these drugs from different angles.

A brief on Ayurvedic manuscripts preserved at Utkal University, Bhubaneswar.

Amongst different institutions, "Parija Library" of Utkal University, Bhubaneswar has about 101 palm-leaf manuscripts (mss.) on Ayurveda to its credit. Most of these mss. have not been reported earlier. Herewith a brief description of these mss. has been made with the intention of bringing it out for the Ayurvedic fraternity and to enrich the literary stock of Ayurveda.