RESUMO
Introduction: With marked growth of the population, rapidurbanization, inappropriate sanitisation and proliferatingtrend of mosquitoes, there is substantial increase in dengueinfections. The fatality rate due to dengue shock syndrome(DSS) can be brought down to as low as <0.2% with carefulmanagement. Understanding the factors which are responsiblefor progression of the disease to the severe stage and death isessential in determining the triage and management steps.Material and methods: All patients suspected to haveprobable dengue / probable dengue fever with warning signswere admitted in government hospital attached to KasturbaMedical College, Mangalore and were given an option ofenrolment in the study. After obtaining informed consent,all potentially eligible patients were screened for enrolment.All necessary blood samples needed to confirm dengue feverand other causes of fever were drawn on the first day. Plateletcounts were done every day till they reach stable levels or tilldischarge.Results: Out of 105 cases (Dengue Fever withoutcomplications), platelet counts (median values) were taken asa parameter. It was observed that the platelet counts are at alowest level on day 2 and day 3 and later on day 4 and day5 it improved. Friedman’s test value = 228.612 and p value<0.001 which was highly significant.Discussion: Thrombocytopenia is a distinctive feature ofdengue and it has been described that its intensity correlateswith the degree of viremia and with the magnitude of theimmune response. It has been suggested that a progressivedecrease in platelets may anticipate the severe form of dengue.
RESUMO
Introduction: Hyponatremia is a state of electrolyteimbalance with a high prevalence rate, it is one of the leadingcause of morbidity and mortality in our settings. The aim ofthis study was to evaluate the clinical features and etiology ofhyponatremia in patients admitted in our government hospital.Material and methods: A 1-year prospective cross-sectionalobservational study was conducted on adult patients withmoderate-to-severe hyponatremia admitted to the hospital.Patients demographics were recorded and investigations weredocumented. Data were analyzed using independent samplet-test.Results: Vomiting (28) followed by confusion (26) was themost common complaint. Confusion was significantly highin patients with severe hyponatremia as compared to patientswith moderate. Increased urine sodium levels were observedin these patientsConclusion: Patients with hyponatremia secondary to aninfectious cause should be meticulously screened and timelyand effective treatment of hyponatremia is determined by theeffective understanding of pathophysiology and associatedrisk factors of hyponatremia.
RESUMO
Background: The susceptibility and severity of Rheumatoid arthritis are determined by both genetic and environmental factors. Dermatoglyphic patterns of individuals which are formed early in the fetal life are also determined by both genetic and environmental factors. Since both are genetically acquired and environmentally modified, it has been shown that there are particular dermatoglyphic patterns associated with Rheumatoid arthritis. If it is so, dermatoglyphics can serve as an additional tool in the early diagnosis and management of such a disabling disease like rheumatoid arthritis. Although there are some studies which mentioned dermatoglyphic pattern variation in the disease, the results are contradicting. Therefore, the present study was undertaken to find out a possible correlation of some quantitative and qualitative dermatoglyphic variables with Rheumatoid Arthritis. Aim of the study: To study the dermatoglyphic patterns in patients with Rheumatoid Arthritis and control population and to study the correlation between dermatoglyphic patterns and Rheumatoid Arthritis. Materials and methods: We studied 60 patients with Rheumatoid arthritis and 60 controls. All were subjected to detailed medical history and clinical examination. Both quantitative (finger ridge count and pattern intensity) and qualitative (fingerprint pattern) dermatoglyphic parameters were studied and the same were compared with age, sex and disease matched controls. Results: Out of the total 60 cases 12(20%) were male and 48(80%) were females. Of the total 60 controls, 12(20%) were males and 48(80%) were females. Analysis of the qualitative parameters revealed: Significant increase in the number of whorls in both the hands of female patients cases compared to the controls (p-value for right hand 0.001, p-value for left hand 0.004). The decrease in the number of radial loops in both the hands of male and female patients and the decrease was more in the left hand in males and right hand in females (p-value male left hand 0.002, female right hand Saritha K. Narayanan, Christopher C. Pais, Pradeep Kumar Shenoy. Use of palmar dermatoglyphics in rheumatoid arthritis - A case-control study. IAIM, 2017; 4(12): 70-76. Page 71 0.003). Decrease in the number of arches in the left hand of female patients compared to the controls (p-0.10). Analysis of the quantitative parameters showed: A statistically significant increase in the finger ridge count of individual hand and the total finger ridge count in both male and female patients compared to the controls (p-value males: right hand 0.003, left hand 0.004, right plus left hand 0.002; p-value females right hand.0000, left hand 0.000, right plus left hand 0.000). A statistically significant increase in the pattern intensity of fingers in female patients compared to the controls (p-value: right hand 0.006, left hand 0.001, right plus left hand 0.000). Conclusion: The findings of this work demonstrate the association between some of the qualitative and quantitative parameters of dermatoglyphics and Rheumatoid arthritis suggesting that dermatoglyphics can represent an anatomical, non-invasive, inexpensive tool for screening high-risk population and thus facilitate early detection and management.