-Lactamases and -Lactamase inhibitors

 b-Lactamases are the major enzymatic mechanism of most resistant bacteria.  They found in many kinds of the pathogen which may be constitutive or inducible.  Sulbactam and clavulanic acid are the most ideal b-Lactamase inhibitors which inhibit enzyme class II, III, IV and V of Richmond and Sykes classification.  The inhibitors are effectively reduced the MIC of amoxycillin or ampicillin in clinical usageKey word : b-Lactamases and b-Lactamase inhibitors

Churg-Strauss Syndrome : A case report

A Case of 29 year-old male presented with history of chronic cough, muscle pain,  arthralgia, progressive weakness of upper and lower extremities and palpable tender small cutaneous nodules for three months.  Physical examination and all laboratory investigations were compatible with Churg-Strauss syndrome, which is a rare disease and never been reported in Thailand.

Pulmonary Roentgenographic Finding of 83 Cases of Melioidosis in Srinagarind Hospital

 From January 1978 to October 1985, eighty-three patients who were correctly diagnosed as melioidosis, by evidence of positive culture of pseudomonas pseudomallei, in Srinagarind Hospital were investigated, concerning about pulmonary involvements of melioidosis, by appearance on roentgenographic findings.  There were 62 cases (74.7%) who had pulmonary involvements which were classified as following : patchy, mottle, streaky infiltration   26 cases (31.3%) multiple nodular infiltration   20 cases (24.4%) pleural effusion/pyopneumothorax  19 cases (22.9%) cavity abscess     19 cases (22.9%) T.B. like     16 cases (19.3%) atelectasis/collapse    12 cases (14.5%) Furthermore, this study also revealed 8 cases of hilar node enlargement, 3 cases of consolidation, 3 cases of pneumonitis/pleuritis, 3 cases of pericardial effusion, 3 cases of mass/masses and a cases of calcification.

Aplastic Anemia in Srinagarind Hospital

We present an analysis of 125 patients with the diagnosis of aplastic anemia seeking care from the Department lf Medicine, Srinagarind Hospital during the last 4 years. Only 78 of 125 cases fulfilled the predefined eligibility criteria and were included in the study 68 patients (87.2 percent) were classified as “severe aplastic anemia”. Our study did not allow any convincing inference about possible etiologic factors. The most common leading symptoms were bleeding tendency and pallor. Only one out of 19 cases (5.26 percent) Who received testosterone propionate for more than six months showed complete response. Septicemia and intracranial bleeding were the two most common causes of 13 deaths.