RESUMO
Introduction: Right ventricular dysfunction is a well known complication or association of Chronic obstructive pulmonary disease (COPD). Only recently the association of Left ventricular dysfunction with COPD has gained importance. Whether this is an independent co-morbidity or a consequence of the COPD is yet to be clearly ascertained but more and more studies are showing Left ventricular dysfunction to be present in patients with COPD. Materials and Methods: We conducted a pilot study in our institutes with 50 patients in our institution. This was an observational Cross sectional study where patients were diagnosed and classified according to GOLD criteria. Results: We found Left Ventricle (LV) dysfunction in about 84% of these patients. Systolic and diastolic dysfunctions were present in 2% cases. Patient’s presenting age, duration and stage of the disease has significant positive correlation with left ventricular diastolic dysfunction. Conclusion: Treatment of this Left ventricular dysfunction was absolutely necessary in the holistic treatment of the patient as left ventricular dysfunction has an independent detrimental effect in COPD patients. As such, we recommend that all COPD patients should have an Echocardiography on first presentation.
RESUMO
Background: There are several conflicting pictures found about blood lipid profile parameters in Chronic Obstructive Pulmonary Disease. Aim: The present study was conducted to evaluate the exact profile of lipid status in COPD and as inflammation has been implicated in the pathogenesis of COPD, is there any association between inflammatory chemokines and lipid profile. Methods: From February 2011 to May 2013 five hundred fifty two patients with COPD presented to Burdwan Medical College and Hospital and 521 subjects having no COPD as age and sex-matched control entered to the study. Diagnosis of COPD was confirmed according to clinical findings and pulmonary function test. Lipid parameters and IL8 in serum were measured in all subjects. Results: The mean level of TG was 148.32±12.18 mg/dl and 134.54±11.78 mg/dl in COPD patients and healthy control, respectively. (p<0.001). The mean level of TC was 186.46±22.91 mg/dl and 173.77±15.21 in COPD patients and healthy control respectively (p<0.001). LDL level mean value was 118.91±12.92 mg/dl and 118.91±12.92 mg/dl in COPD patients and control respectively (p<0.001). The mean value of HDL showed 33.46±4.69 mg/dl in COPD patients and 38.38±5.22 mg/dl in control (p = 0.034). Regression analysis was showed IL8 was statistically significantly correlated with TC (r = 0.785, p <0.001), TG (r = 0.871, p<0.001), LDL (r = 0.882, p<0.001), VLDL (r = 0.679, p=0.016) and HDL (r = -0.681, p=0.012), Conclusion: COPD patients showed significantly higher serum levels of TC, TG, LDL, IL8 and serum concentrations of HDL were also decreased significantly compared to controls. Moreover, lipid profile parameters were well correlated with serum IL8.