A Green Protocol for the Synthesis and Antimicrobial Evaluation of Some Imidazo [1,2-A] Pyrazines.

In this work, we have described a simple and convenient method for the synthesis Imidazo [1,2-a] pyrazine derivatives using 2-amino5-bromo pyrazine, and phenacyl bromide in the presence of DABCO as a catalyst and evaluated as antimicrobial agents. The notable features of this protocol are the simple experimental procedure, short reaction time, easy handling and good yields using a catalytic amount of readily available and cost effective catalyst.

Facile Andgreen Solvent Approach for the Synthesis of Nitrogen Bridgehead-Fused Heterocyclic Nucleus.

Green Chemistry is defined as environmentally benign chemistry. The revolution in green chemistry provides enormous scopes for discovery and even application for new synthetic approaches. An efficient and general method has been described for the formation of imidazo[1,2-a]pyridine from 2-amino pyridine with substituted α- haloketones in the presence of water and acidic additives in efficient yields.