Role Of Supportive Periodontal Therapy (SPT) In Implant Therapy And Periodontitis: A 4-Year Follow-Up

Periodontal diseases include a group of chronic inflammatory conditions usually connected with dysbiotic plaque biofilms leading to progressive destruction of the tooth-supporting apparatus, ultimately leading to tooth loss. Patients with a history of periodontal diseases are potential candidates for dental implant therapy; therefore it is imperative to address the management of implants survival in such patients. This case report depicts an instance of a case of implant-prosthetic rehabilitation in a patient with history of periodontitis,highlighting the importance of initial periodontal treatment and continuous supportive periodontal therapy (SPT) which is fundamental for effective outcome following implant rehabilitation.

Effect Of Sex Hormonal Changes On Serum Lipid Profile In Diabetic And Non-Diabetic Indian Females.

Background: Sex hormones and impaired glucose metabolism resulting from Insulin abnormalities are the major important determinants in the development of coronary heart disease (CHD) in females. The present work was envisaged to study the effect of sex hormonal changes on serum lipids in females of different age groups and physiological status i.e. menstruation and menopause. Methodology: The comparisons were made between diabetic females of both the phases (menstruation and menopause) and age matched non-diabetic females. Further comparisons were made between diabetic females of menopause phase and diabetic females of menstruation phase. Results: In the study when comparisons were made between menstruating diabetics and menstruating non-diabetics, the former group showed significant increase in plasma glucose, serum total cholesterol (TC), Triglyceride (TG), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels. Similarly comparisons were made between menopausal diabetics and menopausal non-diabetics, the former group showed significantly higher levels of plasma glucose, serum TC, TG, LDL and VLDL. However it is noticed that HDL levels did not very significantly in both the comparisons. Also in diabetic menopausal females there is a significant increase in serum TG levels as compared to diabetic menstruating females. Conclusions: In present study, in non-diabetic menopausal females there is a significant increase in plasma glucose, serum TC, TG, LDL and VLDL concentration levels as compared to non-diabetic menstruating females. Also in diabetic menstruating and menopausal females, there is a significant increase in plasma glucose, TC, TG and VLDL levels as compared to non-diabetic menstruating and menopausal females.

Effect of alternative therapy on cardiorespiratory and sensory parameters of chronic type 2 diabetes mellitus patients.

Background: The incidence of diabetes mellitus is increasing every year throughout the world. Yogic exercises with diet therapy can be an easy way of management of diabetes to maintain blood sugar level and prevent various degenerative changes in different systems to remain healthy. Methods: Fifty two known chronic type 2 diabetic patients were managed through yogic exercises and diet therapy for 150 days. Physiological parameters were studied in all subjects. Results: Diastolic blood pressure, positive breath holding time, pain threshold and tactile discrimination showed changes within 15 to 30 days of regime. There was reduction in body weight and respiratory rate. The rise was observed in 40 mm of mercury endurance test and positive breath holding time. Both pain threshold and tactile discrimination showed increase of sensitivities. Conclusion: Improved physiological parameters indicate that yogic exercise, meditation and diet control regularly can manage type 2 diabetes in a natural way avoiding the side effects of oral hypoglycemic medications. Patients should continue the therapy to control the disease life time for better health without oral hypoglycemic medication.

Serum calcium, magnesium and inorganic phosphorous levels during various phases of menstrual cycle.

Serum Calcium (Ca), Magnesium (Mg) and Inorganic phosphorous (Pi) were investigated serially during menstrual, follicular, ovulatory and luteal phases of menstrual cycle in 25 healthy medical student volunteers. The result shows significant cyclic variations within physiological limits in all parameters. Ca level was highest during ovulation (P < 0.001) and lowest during luteal phase (P < 0.001) compared to other phases. Exactly opposite result was observed for Ca level. It is lowest during ovulation (P < 0.001) and highest during the luteal phase (P < 0.001). However, the highest level of Pi was seen during menstrual phase (P < 0.001) and lowest during the luteal phase (P < 0.001). These changes are probably brought about under the influence of cyclic variations of the ovarian hormones.

Effect of simultaneous low level exposure of Pb and Cd on delta-ALAD and acetylcholinesterase activity in rats.

Dose dependent study was performed to identify subcritical level of Pb and Cd. Blood delta-ALAD activity was inhibited by (0.1 mg/kg body wt) of both lead and cadmium in isolation and combination, the extent of which increases with duration of exposure. Hepatic delta-ALAD activity however is less affected by Cd and Pb-Cd together than Pb alone. Erythrocyte acetylcholinesterase activity though decrease in all groups, is not significant.

Trichloroethylene toxicity in mice: a biochemical, hematological and pathological assessment.

Oral administration of trichloroethylene (TCE; 0, 500, 1000 and 2000 mg/kg/day) to male mice once daily, 5 days a week for a period of 28 days, caused a significant increase in liver weight, degeneration/necrosis of hepatocytes and characteristics proliferation of endothelial cells of hepatic sinusoids. Increase in kidney weight, glomerular nephrosis, degeneration/desquamation of tubular epithelium and characteristic amyloid deposition in glomeruli were observed only in the group of mice treated with 2000 mg/kg TCE. These changes occurred concurrently with a significant increase in total protein and free sulphydryl contents, elevated activities of acid phosphatase and catalase and decreased activity of delta-aminolevulinic acid dehydratase (delta-ALAD) indicating the sensitivity of liver and kidney as target tissues in TCE-toxicity. Hematological studies showed a significant increase in RBC counts and a reduction in WBC counts without any statistically significant change in the hemoglobin, urea nitrogen, creatinine and uric acid levels in the blood of TCE-exposed mice. A dose-related increase in cell density and acid phosphatase activity with a parallel significant decrease in the activity of delta-ALAD were observed in the bone marrow, which appear to be responsible for hematological alterations in TCE-exposed mice. The results suggest that early metabolic, pathological and hematological perturbations following a short-term exposure of TCE in mice, can provide the basis for its documented potential for chronic effects like blood dyscrasia and cancer.

Tissue sensitivity to acetylcholine, adrenaline, noradrenaline and serotonin and agents acting on sulphydryl groups.

Parachloromercury benzoate (PCMB), a sulphydryl inactivator, caused a progressively increasing inhibition of tissue responses to acetylcholine, adrenaline, noradrenaline and serotonin in vitro. This inhibition was progressively and completely reversed by penicillamine, a sulphydryl activator. It is inferred that intact sulphydryl groups are essential for constancy of responses of excitable tissues to the neurotransmitters.

Serum electrolytes during various phases of menstrual cycle.

The corollary follow up study carried presents variation in electrolyte content of serum during menstrual, follicular, ovulatory and luteal phases of menstrual cycle. Variation in sodium, potassium and chloride were found to be parallel with each other. Their level increase significantly from follicular to ovulatory phase and falls significantly during luteal phase. Bicarbonate levels are higher in follicular and luteal phases while they are lower in menstrual and ovulatory phases.