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Chinese Journal of Natural Medicines (English Ed.) ; (6): 904-912, 2016.
Artigo em Inglês | WPRIM | ID: wpr-812542

RESUMO

Thymoquinone (TQ), an active component derived from the medial plant Nigella sativa, has been used for medical purposes for more than 2 000 years. Recent studies have reported that TQ blocked angiogenesis in animal model and reduced migration, adhesion, and invasion of glioblastoma cells. We have recently shown that TQ could exhibit a potent cytotoxic effect and induce apoptosis in mouse neuroblastoma (Neuro-2a) cells. In the present study, TQ treatment markedly decreased the adhesion and migration of Neuro-2a cells. TQ down-regulated MMP-2 and MMP-9 protein expression and mRNA levels and their activities. Furthermore, TQ significantly down-regulated the protein expression of transcription factor NF-κB (p65) but not significantly altered the expression of N-Myc. Taken together, our data indicated that TQ's inhibitory effect on the migration of Neuro-2a cells was mediated through the suppression of MMP-2 and MMP-9 expression, suggesting that TQ treatment can be a promising therapeutic strategy for human malignant neuroblastoma.


Assuntos
Animais , Humanos , Camundongos , Apoptose , Benzoquinonas , Farmacologia , Linhagem Celular Tumoral , Regulação para Baixo , Metaloproteinase 2 da Matriz , Genética , Metabolismo , Metaloproteinase 9 da Matriz , Genética , Metabolismo , Neuroblastoma , Tratamento Farmacológico , Genética , Nigella sativa , Química , Extratos Vegetais , Farmacologia
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