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1.
Artigo em Inglês | IMSEAR | ID: sea-64614

RESUMO

A 27-year-old man, who had symptoms of gastric outlet obstruction, was found on endoscopy to have a large duodenal polyp which on histology was diagnosed as villous adenoma. The tumor was resected surgically and the patient remained asymptomatic until two years later.


Assuntos
Adenoma Viloso/diagnóstico , Adulto , Neoplasias Duodenais/diagnóstico , Obstrução da Saída Gástrica/etiologia , Humanos , Masculino
2.
Artigo em Inglês | IMSEAR | ID: sea-95125

RESUMO

Helicobacter (Campylobacter) pylori has been cultured from the antral biopsies of 85-90% of patients of gastritis, gastric ulcer and duodenal ulcer at different centres. Studies conducted all over the world have firmly implicated this organism in the aetiology of active superficial gastritis and recurrences of duodenal ulcer. Two hundred patients with upper abdominal pain, distension, vomiting and/or haemetemesis were subjected to OGD scopy. In 163 of these patients there was endoscopic evidence of gastritis; in 24 there was DU; in 3, GU and in 10 it was normal. Diagnosis of H pylori infection was made by the rapid biopsy urease test which is nearly 100% specific and 98% sensitive. 170 out of 200 patients were positive for H pylori. Among these were 138 patients of gastritis (84.6%); 22 cases of DU (91.6%); 2 cases of GU (66.6%) and 8 in whom endoscopy was normal. Histological examination of the antral biopsy specimens showed mild to severe infiltration of mucosa with lymphocytes and plasma cells. None of the 170 H pylori positive cases showed polymorphonuclear infiltration which has been stressed repeatedly by most Western authors to be characteristic of "active" superficial gastritis associated with H pylori infection. Even in those with a history of dyspepsia of barely 4 weeks duration or less there was no PMN infiltration in the mucosa. Thus the local response to infection by H pylori of the gastric mucosa is different in Indian patients.


Assuntos
Adolescente , Adulto , Amoxicilina/uso terapêutico , Úlcera Duodenal/microbiologia , Feminino , Mucosa Gástrica/microbiologia , Gastrite/microbiologia , Infecções por Helicobacter , Helicobacter pylori , Humanos , Índia , Masculino , Pessoa de Meia-Idade , Urease/diagnóstico
3.
Artigo em Inglês | IMSEAR | ID: sea-95311

RESUMO

In a double-blind randomised trial, 40 patients with active gastric or duodenal ulcer were treated with a single nocturnal dose of famotidine 40 mg or ranitidine 300 mg for 4 to 8 weeks. Antacid tablets were allowed as additional treatment, only if needed, for pain relief. Endoscopy was repeated after 4 weeks, and if the ulcer had not healed at 6 and/or 8 weeks. Relief of upper gastro intestinal symptoms with which the patient presented and the number of antacid tablets consumed, if any, were recorded on weekly basis. Two patients in famotidine group and 5 patients in ranitidine group did not complete the therapy and were considered dropouts. At the end of therapy, ulcers in 100% of the patients receiving famotidine & 93% of patients receiving ranitidine were healed. This difference was not statistically significant. Relief from ulcer related symptoms was rapid in both the groups. None of the patients in either group reported side effects. Overall opinion of investigator was comparable for both the treatments; however, significantly (P = 0.0334) larger proportion (100%) of patients from famotidine group rated it as an excellent therapy compared to only 73% from ranitidine group. Famotidine provides excellent healing of ulcers and early relief of upper gastrointestinal symptoms in Indian patients with peptic ulcer.


Assuntos
Adulto , Método Duplo-Cego , Úlcera Duodenal/tratamento farmacológico , Famotidina/administração & dosagem , Feminino , Humanos , Índia , Masculino , Ranitidina/administração & dosagem , Úlcera Gástrica/tratamento farmacológico , Cicatrização/efeitos dos fármacos
4.
Artigo em Inglês | IMSEAR | ID: sea-94684

RESUMO

Helicobacter pylori infection of gastric antrum is associated with a majority of cases of peptic ulcer (70-100%). Studies have shown that when this organism is eradicated, the recurrence of ulcer falls to less than one-third of those in whom the infection persists or relapses. Monotherapy with bismuth salts, tinidazone or amoxycillin has been shown to result in early relapse and recurrence of ulcers. However, dual or triple therapy regimens are more effective. We conducted a randomised controlled study using tripotassium dicitrato bismuthate (TDB) (10 patients); amoxycillin (combined with ranitidine for ulcer healing) (9 patients) and dual therapy with both amoxycillin and TDB (10 patients). Our study showed that relapse rates at the end of 3 months was significantly less if dual therapy with TDB and amoxycillin is used as compared to TDB alone (p less than 0.05).


Assuntos
Amoxicilina/administração & dosagem , Antiulcerosos/administração & dosagem , Quimioterapia Combinada , Seguimentos , Infecções por Helicobacter/tratamento farmacológico , Helicobacter pylori , Humanos , Compostos Organometálicos/administração & dosagem , Úlcera Péptica/tratamento farmacológico , Ranitidina/administração & dosagem , Recidiva
5.
Artigo em Inglês | IMSEAR | ID: sea-88800

RESUMO

Helicobacter pylori is associated with 70-100% of peptic ulcers. Relapse of infection has been shown to cause recurrences of ulcers in a large number of studies. We diagnosed 137 cases of peptic ulcer (121 DU; 16 GU) during a 3 year period. Of these, 117 were positive for H pylori. Sixty six of the 117 cases staying in the vicinity of the Hospital were followed up for a minimum period of 3 months upto a maximum period of 3 years. In 91 examinations there was relapse of H pylori infection and ulcer recurrence was seen in 58 (63%), whereas ulcer recurred only in 6 out of 61 examinations where H pylori had not relapsed (10%). The difference was highly significant by Chi square test. (P less than 0.001).


Assuntos
Adolescente , Adulto , Feminino , Seguimentos , Gastroscopia , Infecções por Helicobacter , Helicobacter pylori , Humanos , Masculino , Pessoa de Meia-Idade , Úlcera Péptica/microbiologia , Recidiva
8.
Indian J Ophthalmol ; 1973 Jun; 21(2): 90-1
Artigo em Inglês | IMSEAR | ID: sea-72458
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