Retained iatrogenic foreign body causing persistent non-healing wound: a case report

An 88-year-old female presented with non-healing wound of left hip, found to have iatrogenic foreign body. The patient presented at the age of 88 with complaints of a persistent wound of left hip. She had a previous incision and drainage of an abscess on her left hip and subsequently received negative pressure therapy. She underwent a wound exploration and found to have multiple foreign bodies in the wound. While uncommon, iatrogenic foreign body should be considered as a possible differential diagnosis in patient with non-healing wounds. The literature on iatrogenic foreign body is reviewed. Iatrogenic foreign body is an uncommon pathology but should be included in the differential diagnosis in patients presenting with a non-healing wound.

Clinico-Epidemiological Study of Patients Suffering from Sickle Cell Anaemia In a District Level Private Hospital of a Tribal District in South Gujarat

Introduction: Sickle cell disorder is an autosomal recessive condition, in which inheritance of an affected gene from both parents results in a disorder. According to hospital based epidemiological survey, the prevalence of sickle cell gene is observed among tribal population, which accounts for 15 % of the total population of Gujarat and are distributed in various districts. Objectives: To study clinical profile, epidemiological characteristics and socio-demographic features of persons having sickle cell disease and sickle cell trait and establish relationships if any of the epidemiological profile with the clinical and sociodemographic features of the study subject Method: The study was carried out in Janak Smarak hospital in Vyara Town, Tapi District. It was a descriptive cross-sectional study for a period of one year and minimum of 75 persons with sickle cell disease and 150 persons with sickle cell trait was taken for the study Results: Proportion of females affected were more than that of the male. Majority of the participants belonged to Gamit caste and most of them were Hindus. Majority of the participants were married and it was significantly associated with Sickle cell status of the individuals. Majority of sickle cell disease patients had clinical manifestations of sickle cell crisis like pain in both upper and lower limbs; weakness, fever and body ache and sign of pallor. Nearly half of the sickle cell disease patients had a history of blood transfusion Conclusion: Family history and predisposition happens to remain one of the most important predictors of the Sickle cell status among the population. Nearly more than half of the Sickle Cell Disease patients needed regular transfusion with Blood or any of its components. This points out the necessity of establishing these units in higher numbers in tribal areas

Respiratory Morbidities among Workers Employed in Cotton Industries in Surendranagar City

Introduction :According to a publication in 1986by the World Health Organization (WHO) on Pneumoconiosis and Smoking, workers in cotton processing industries have the risk of developing obstructive respiratory conditions such as Bysinosis and Occupational Asthma, due to prolonged exposure to inhalable cotton dust particles, bracts and pericarps as well as to bacteria and fungi that may grow on cotton products. Objectives:To identify the presence of Respiratory symptoms among those exposed to cotton dust and To associate the findings with the duration of exposure of cotton dust. Methods :The study carried out was cross sectional and in 3 cotton industries in Surendranagar city. A total of 144 workers who consented for the study were selected and were interviewed and examined for respiratory signs. Results :Nearly 78% of the subjects had respiratory complaints. Most of the workers had had a more than 10 year exposure to cotton dust. Majority of symptoms were dyspnoea and expectorations. Nearly 95% of the subjects had the habit of consumption of smokeless tobacco. Conclusion:It can be concluded from the study, that the risk factors for Respiratory diseases are highly prevalent among workers employed in industrial set ups involving respirable dusts. More than 80% of the workers had 10 yrs or more years of exposure to cotton dust and the association of the exposure with the respiratory problems was proved statistically significant.

An ideal oocyte activation protocol and embryo culture conditions for somatic cell nuclear transfer using sheep oocytes.

Pluripotent stem cells are possibly the best candidates for regenerative medicine, and somatic cell nuclear transfer (SCNT) is one of the viable options to make patient-specific embryonic stem cells. Till date efficacy of SCNT embryos is very low and requires further improvement like ideal oocyte activation and in vitro culture system. The aim of the present study was to evaluate ideal oocyte activation using different stimulation protocols and to study the effect of cumulus co-culture conditions on embryo development. Results demonstrate that between electric stimulation and chemical stimulation using calcium ionomycin and ionophore, best oocyte activation was obtained using calcium ionomycin (5 μM for 5 min) which resulted in 83% cleavage followed by 7% of early blastocyst which further increased to 15% when a cumulus bed was also introduced during embryo culture. Sequential modified Charles Rosenkrans 2 (mCR2) medium was used for embryo culture in which glucose levels were increased from 1 mM to 5 mM from Day 3 onwards. SCNT using cumulus cells as donor somatic cell, calcium ionomycin to activate the reconstructed oocyte and embryo culture on a cumulus bed in sequential mCR2 medium, resulted in the development of 6% embryos to early blastocyst stage. Such technological advances will make SCNT a viable option to make patient-specific pluripotent stem cell lines in near future.

Efficacy of chlorhexidine versus betadine as an irrigating agent during removal of bilateral impacted lower third molars

A prospective double blind study was carried out tocompare the efficacy of 0.02% chlorhexidine and 0.5% povidone iodine as an irrigating agent on control of pain and swelling following removal of bilaterally impacted lower third molars. Twenty patients with bilaterally impacted lower third molars, in similar positions were included in the present study. All the patients underwent surgical removal of the bilaterally impacted third molars in the same appointment. 0.02% chlorhexidine was used as an irrigating agent during the surgical procedure on a randomly selected one side [Group I] and 1% povidone iodine [Group II] was used on the other side [Group II]. Postoperative pain intensity was more pronounced in the Group II than in Group I [P < 0.05]. There were no significant differences in swelling between the two groups [P > 0.05]. Alveolar osteitis was noted in one case [5%] in Group II whereas it was nil in Group I. In conclusion, chlorhexidine was found more effective in control of postoperative pain and alveolar osteitis than povidone iodine when used for irrigation during the surgical removal of lower third molars. The control of swelling is similar in both the agents