Polymeric nanoparticle formulation of Octapeptide (NP-OP): In vitro release and in vivo effect in common marmosets, Callithrix jacchus Linn.

yielded an average particle size of 120 nm with 70% encapsulation-efficiency. In vitro release profile of NP-OP showed sustained release of OP for 21 days. In vivo anti-fertility studies were conducted in marmosets. Results indicated that control animals conceived in the same cycle while two of three treated animals failed to conceive in treatment cycle. The in vivo studies thus corroborate with in vitro release of OP, demonstrating its anti-fertility activity in 66% of animals.

Sero prevalence of C.trachomatis in patient of Bad Obstetric History (BOH).

Background : Bad obstetric history (BOH) implies previous unfavorable fetal outcome. Causes of BOH may be genetic, hormonal, abnormal maternal immune response and maternal infection. C.trachomatis is the most common bacterial sexually transmitted infection worldwide. Also it has been associated with adverse outcomes of pregnancy. The identification of C. trachomatis during pregnancy and its early treatment prior to delivery would therefore be an important strategy to prevent multiple complications in mother. Serology might act as a convenient tool for diagnosis. Methods:139 pregnant patients having history of BOH as study group and 30 normal pregnant as control group were tested by Indirect ELISA for detection of anti C.trachomatis IgM and IgG. Results: Anti C.trachomatis IgM was detected in 21 (15.11%) patients and anti C.trachomatis IgG was detected in 33 (23.74%) patients. Interpretation and Conclusion: Higher numbers of positive patients were found among younger age group. Statistical analysis shows that serological detection of anti C.trachomatis IgM and IgG antibodies for detection of current and past infection by C.trachomatis is significant in BOH patients.

Papillary cystadenocarcinoma arising in a paratubal mesothelial cyst of the mesosalpinx--a case report.

Primary carcinoma arising from a paratubal cyst in the mesosalpinx in uncommon. Serous tumors of low malignant potential outnumber invasive carcinomas, which are often of endometrioid type. Only five cases of serous papillary cystadenocarcinoma with capsular invasion have been documented. We report a case of invasive papillary cystadenocarcinoma arising in a large paratubal cyst of the mesosalpinx, in an infertile woman. Possible hormonal basis, its link to serous borderline and malignant tumors of the peritoneum, and value of pre/intra operative cyst fluid cytology are discussed. Lack of definitive management protocols, prognostic indicators and possible consequences are briefly reviewed.