Penicillin-Induced Stevens–Johnson Syndrome: A Case Report.

Stevens–Johnson syndrome (SJS) is one of the manifestations of severe form of cutaneous adverse drug reactions (CADRs). Penicillin group of antibiotics is well-known to cause the CADRs. Few cases of amoxicillin and only one case of dicloxacillininduced SJS have been reported. To the best of our literature search, we have not come across a single case of amoxicillin– dicloxacillin-induced SJS. Here, we report a case of amoxicillin–dicloxacillin-induced SJS in a 28-year-old female patient. The rationality of amoxicillin–dicloxacillin fixed drug combination is doubtful. Hence, prescribing rational drug therapy and promptly reporting the adverse drug reactions is essential so that noncompliance to treatment with resultant therapeutic failure and augmented antimicrobial resistance can be avoided.

Cutaneous Drug Eruption Caused by Amoxicillin: A Case Report.

Amoxicillin is a commonly used antimicrobial agent to combat various infections. Penicillin group of drugs are known to cause cutaneous drug eruptions especially in pediatric population. Most of the time, these eruptions are mild in nature, however, sometimes they represent the early manifestation of rare, severe drug-induced cutaneous reactions, such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Here, we report a case of maculopapular, erythematous rash induced by amoxicillin in an 18-year-old male patient. The case is being reported to emphasize the need for efficient pharmacovigilance in order to motivate adverse drug reaction reporting so as to gather more and more data regarding adverse drug reactions.

Lepromatous leprosy of histoid type.

Histoid leprosy is a variant of lepromatous leprosy, which develops as a result of resistance to dapsone monotherapy. Here we report two cases of lepromatous leprosy of histoid type, one with typical and another with atypical presentations.

Distribution and in vitro antimicrobial susceptibility of Acinetobacter species on the skin of healthy humans.

BACKGROUND: Acinetobacter spp. are ubiquitous in the environment and have emerged as important nosocomial pathogens. The distribution of Acinetobacter spp. In some temperate European countries has been reported. However, similar data from a tropical country such as India are not available. METHODS: Six body sites (antecubital fossa, axilla, forehead with hairline, neck, outer surface of nose and toe webs) from men and women volunteers were sampled with saline-soaked cotton swabs enriched in Baumann's enrichment medium. The isolates were identified to the genus level by chromosomal DNA transformation assay and to the species level by a 16-test biochemical system. The minimum inhibitory concentration for 39 antibiotics was determined by the two-fold agar dilution method. RESULTS: Seven genospecies of Acinetobacter were found at 6 body sites on healthy human skin. Acinetobacter lwoffii was the most dominant comprising 40% of the total number of isolates, followed by A. junii (35%) and A. haemolyticus (16.5%). The antecubital fossa had the highest colonization frequency (48.5%). The overall positivity rate of samples was higher from women (26.3%) compared to men volunteers (25%). Only two Acinetobacter genospecies 1-3 isolates were isolated while no A. radioresistens were isolated. Susceptibility testing revealed no major differences among the 7 Acinetobacter spp. tested. Fluoroquinolones were the most active, while low-to-intermediate resistance was exhibited towards beta-lactams and aminoglycosides. Acinetobacter spp. isolated from the skin showed susceptibility to commonly used antibiotics. CONCLUSION: Seven Acinetobacter genospecies were isolated from 6 different body sites from the skin of healthy human volunteers. Acinetobacter lwoffii was the dominant isolate. The rate of skin carriage was higher in men than in women and the maximally colonized site was the antecubital fossa. All the genospecies displayed susceptibility to most of the commonly used antimicrobials.