1.
Hindustan Antibiot Bull
; 1994 Feb-May; 36(1-2): 34-8
Artigo
em Inglês
| IMSEAR
| ID: sea-2430
RESUMO
Polyene antibiotics are known for their remarkable antifungal properties. The alkali metal and quaternary alkylammonium salts of amphotericin B, nystatin and aureofungin have been prepared by ion-exchange method. The physico-chemical and biological properties of these salts have been studied with a view to evaluate their therapeutic advantages over the parent compounds. While the majority of the salts reported herein showed more water solubility; triethylammonium salts, unlike the other alkali metal salts, possessed marginally improved or similar bioactivity in comparison to their parent antibiotic having reduced toxicity.