RESUMO
Objective·To investigate the correlation between mild cognitive impairment (MCI) and bone metabolism level in the elderly.Methods·Fifty patients with MCI and ninety controls with normal cognitive function were recruited from Department of Gerontology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine.Plasma levels of calcium and phosphorus metabolism indicators,bone resorption markers and bone formation markers were measured.Cognitive function was assessed by mini mental state examination (MMSE) and Montreal cognitive assessment (MoCA).Results·Plasma level of osteocalcin was elevated in patients with MCI (P=0.001) compared with controls,while plasma level of calcium was decreased in the MCI group (P=0.045).Among patients with MCI,the score of MMSE positively correlated with plasma level of 25-hydroxy vitamin D3 (r=0.290,P=0.041),while negatively correlated with plasma level of parathyroid hormone (r=-0.349,P=0.025).Conclusion·MCI may be correlated with bone metabolism level in the elderly.
RESUMO
Recently,the incidence of Alzheimer's disease has been significantly increasing.However,the pathogenesis of Alzheimer's disease remains unknown.It is presumed that insulin and insulin receptor may be involved in the pathogenesis of Alzheimer's disease.The relationship between insulin and cerebral glucose metabolism,the relationship between insulin,insulin receptor,insulin resistance and pathogenesis of Alzheimer's disease as well as the possible mechanism are reviewed in this paper,and the progress of treatment of AD is also described.