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Artigo em Chinês | WPRIM | ID: wpr-355078

RESUMO

<p><b>OBJECTIVE</b>To evaluate the effects of levonorgestrel-releasing intrauterine system (LNG-IUS) combined with GnRH analogue (GnRH-a) in the treatment of adenomyosis with uterine body enlargement.</p><p><b>METHODS</b>Twelve women (mane age 40.3 years) with adenomyosis and uterine cavity depth over 11 cm received injections of GnRH-a every 4 weeks, and after the uterine cavity depth was reduced to below 10 cm, LNG-IUS was deployed. VAS pain score, PBAC bleeding score, uterine volume, and hemoglobin levels of the women were measured before the treatment and at 6 and 12 months after LNG-IUS placement.</p><p><b>RESULTS</b>The VAS pain score was significantly lowered at 6 and 12 month after LNG-IUS placement (P<0.05), and the PBAC bleeding score also showed significant reductions (P<0.05). The uterine volume decreased significantly at 6 and 12 months after LNG-IUS placement as compared with that before the treatment, but was significantly greater at 6 month in comparison with that at the time of LNG-IUS placement (P<0.05). Serum hemoglobin levels underwent significant increments after LNG-IUS placement (P<0.05).</p><p><b>CONCLUSION</b>LNG-IUS combined with GnRH analogue injection can be effective in the treatment of adenomyosis with dysmenorrhea and hypermenorrhea.</p>


Assuntos
Adulto , Feminino , Humanos , Preparações de Ação Retardada , Quimioterapia Combinada , Endometriose , Tratamento Farmacológico , Hormônio Liberador de Gonadotropina , Usos Terapêuticos , Levanogestrel , Doenças Uterinas , Tratamento Farmacológico
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