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Objective To investigate the role of transforming growth factors(TGF-?1 and ?2) in the pathogenesis of scleroderma(SD). Methods The mRNA expression of TGF-?1 and ?2 in the skin lesions from 17 patients with SD and skin from 10 normal controls were detected with in situ RT-PCR technique. Results A higher positive rate and stronger expression of TGF-?1 mRNA in SD skin lesions were seen, compared with those in controls(P0.05).The higher positive rate and stronger expression of TGF-?1 mRNA than TGF-?2 mRNA in SD were seen(P
RESUMO
30 patients (16 females 14 males; age of 7-72 years, the mean age of45. 4 years)with various pemphigus for the first time admitted to our hospitalduring the period of 1959-1979 have been studied. It was important torecognize mucous lesions in the early stage of diagnosing the disease. Itwas fouud that the disease was characterized with their living district. Thecorticosteroid therapy and early application of immunosuppressive wasdiscussed. It sbould be suggested that the local application of Rivanolointment gauze give good results.