RESUMO
Objective To investigate the effects of metoprolol on Myocardial remodeling and cardiac function in type 2 diabetic patients with chronic heart failure.Methods 70 type 2 diabetic patients with chronic heart failure were randomly divided into treatment group and control group.Both groups were given conventional anti-heart failure treatment.The patients in the treatment group were administered with oral metoprolol.Two groups were treated for 12 weeks.The changes of cardiac function, left ventricular posterior wall thickness (LVPWTH), left ventricular end diastolic diameter ( LVEDD ) , left ventricular end systolic diameter ( LVESD ) , left ventricular ejection fraction ( LVEF) and E/A were observed before and after treatment in both groups.Results After treatment, the total effec-tiveness rate of the clinical curative effect in the treatment group was 85.71%, significantly higher than the control group (p<0.05).LVPWTH, LVEDD and LVESD decreased after treatment, while LVEF and E/A increased. These changes were more significant in the treatment group, with statistically significant difference between two groups ( p<0.05) .There was no significant effect of metoprolol on glucose and lipid metabolism in patients with type 2 diabetes mellitus.No serious adverse drug reaction was observed in both groups.Conclusion Metoprolol can reverse or delay left ventricular remodeling in type 2 diabetic patients with chronic heart failure, and can also improve cardiac function.
RESUMO
Objective To investigate the changes of cardiac structure and function in type 2 diabetes mellitus (T2DM), analyze the related risk factors of heart failure, and improve the awareness of the effect of diabetes on the heart. Methods Randomly selected 170 cases of T2DM patients As the object of study, 170 cases of non diabetic patients as con-trol group, according to whether complicated with heart failure were divided into heart failure patients and non heart failure patients.Comparison of each group left ventricular posterior wall thickness, left ventricular end diastolic diameter, left ven-tricular end systolic diameter, left ventricular ejection fraction, E/A ratio Differences, analysis of the related risk factors of heart failure by logistic regressive.Results T2DM group left ventricular posterior wall thickness, left ventricular end diastolic diameter and left ventricular end systolic diameter increased , Left ventricular ejection fraction decreased, E/A ratio de-creased, were statistically significant difference compared with the control group (p <0.05).These differences are mainly come from non heart failure patients.Logistic regression showed that factors in patients with diabetes duration, HbA1c, com-pliance and complications of hypertension, coronary heart disease, is a risk factor for heart failure complicated with T2DM (all p<0.01).These may be the risk factor for diabetic patients with heart failure.Conclusion Diabetes can cause cardiac remodeling, systolic and diastolic dysfunction maybe some T2DM patients.They did not show symptoms of heart failure in the clinical, but their Cardiac structure and function are abnormal.We should pay attention to the cardiac function examination and early evaluation, prevention of risk factors, to avoid the occurrence of heart failure.