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Objective:To observe any effect of combining the anti-asthmatic drug montelukast with exercise therapy on the pulmonary function, clinical symptoms, functional exercise capacity and quality of life of children with asthma.Methods:Seventy children (between 7 and 14 years old) with mild asthma were randomly divided into an observation group ( n=35) and a control group ( n=35). Both groups were given the anti-asthmatic drug montelukast, while the observation group was additionally provided with breathing training and aerobic pedaling training. Before and after the intervention, both groups′ forced expiratory volume in 1 second, forced vital capacity and 6min walking test (6MWT) distance were tested. Their asthma symptoms were scored using the pediatric asthma quality of life questionnaire (PAQLQ). Any adverse events during the study were recorded. Results:After 8 weeks the observation group′s average 6MWT distance, total PAQLQ score, as well as the scores on each domain of the PAQLQ (symptoms, activity restriction, emotions) had improved significantly. The observation group′s average heart rate and perceived exertion rating after the 6MWT had also improved significantly, as had their average daytime and nighttime asthma symptom scores. The control group also demonstrated significant improvement in their PAQLQ symptom scores and their daytime and nighttime asthma symptom scores after the intervention. There was no significant difference in the incidence of adverse reactions between the two groups.Conclusions:Supplementing montelukast with exercise is effective and feasible in the treatment of children with mild asthma, with good safety and tolerance. Such combined therapy is worthy of further research and promotion.
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Objective:To explore the effect of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on the aerobic capacity of middle-aged and elderly patients with type 2 diabetes.Methods:A total of 95 patients with type 2 diabetes (aged 45 to 70 years) were randomly divided into an HIIT group ( n=35), an MICT group ( n=35) and a sedentary control group (CON group) ( n=25). All of the subjects maintained their daily habits, but the HIIT and MICT groups performed their corresponding exercise using a bicycle ergometer 4 times/week for 8 weeks. Before and after the 8 weeks, each subject′s maximum oxygen uptake (VO 2max) was measured using a graded exercise test. Results:Eighty-three of the subjects (87.4%) completed the study. The follow-up loss rate in the HIIT group was 13% and in the MICT group it was 14%. After the intervention, the average VO 2max had increased by (11.5±2.3)% in the HIIT group and (8.1±1.9)% in the MICT group, a difference which is not significant. Conclusion:Either HIIT or MICT is feasible, well tolerated, safe and effective for improving the aerobic capacity of middle-aged and elderly patients with type 2 diabetes.
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Objective:To compare the effect of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on the abdominal visceral fat of obese women.Methods:Sixty-eight obese female college students were randomly divided into an HIIT group ( n=23), an MICT group ( n=22) and a control group ( n=23). The control group was not given any training intervention. The MICT group performed continuous exercise at an intensity of 60% of each person′s maximum oxygen uptake (VO 2max) until 300kJ of work had been performed. Those in the HIIT group performed repeated 4-minute bouts of cycling at 90% of their VO 2max with 3-minute intervals until 300kJ of work had been performed. The interventions lasted 12 weeks. The subjects′ visceral fat (AVFA) and abdominal subcutaneous fat (ASFA) were measured using computed tomography. Whole-body fat mass (FM) and FM in the android, gynoid and trunk regions were detected using dual energy X-ray absorptiometry before and 48 hours after the final session. Results:After the intervention, the average AVFA, ASFA, percentage of fat mass (FM%), whole-body FM, and FM in the abdominal, gluteo-femoral and trunk regions of the HIIT group and MICT group were significantly lower than before the intervention, but there was no significant difference between them. No significant differences were observed in any of the control group′s indexes.Conclusions:Both HIIT and MICT can reduce the abdominal visceral fat of obese female college students, and the effects of the two exercise modes are equivalent.