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1.
An. acad. bras. ciênc ; 73(1): 33-7, Mar. 2001. ilus, tab
Artigo em Inglês | LILACS | ID: lil-281082

RESUMO

The essential oil from Piper solmsianum leaves and its major compound (sarisan) were tested to verify their influences upon mice behaviour. The essential oil was obtained by hydrodistillation in a modified Clevenger extractor and analysed by GC/ MS. This analysis revealed in the oil the presence of monoterpenes, sesquiterpenes and of arylpropanoids. The compound sarisan, a myristicin analogue, was isolated from the oil to perform the pharmacological tests. Emulsions of the oil and of sarisan (5.0 and 10.0 percent v/v) were used in the tests. Pentobarbital (30 mg/ kg s.c.) or diazepam (2.5 mg/ kg s.c.) were tested as standard drugs to verify depressant or anxiolytic effects, respectively. Both essential oil and sarisan showed to have exciting and depressant effects in the tested animals


Assuntos
Animais , Masculino , Feminino , Camundongos , Comportamento Animal/efeitos dos fármacos , Óleos Voláteis/farmacologia , Óleos de Plantas/farmacologia , Acatisia Induzida por Medicamentos/fisiopatologia , Antifúngicos/farmacologia , Depressão/induzido quimicamente , Diazepam/farmacologia , Dioxolanos/farmacologia , Hipnóticos e Sedativos/farmacologia , Pentobarbital/farmacologia , Extratos Vegetais/farmacologia , Folhas de Planta , Ratos Endogâmicos
2.
Ciênc. cult. (Säo Paulo) ; 49(5/6): 354-8, Sept.-Dec. 1997. tab, graf
Artigo em Inglês | LILACS | ID: lil-214096

RESUMO

The world over, many plants are being used successfully - mainly in the form of teas - to counteract the effects of diabetes; and Brazil is no exception. This is especially true for patients suffering from noninsulin dependent (type II) diabetes. The article first summarizes the mechanisms reported in the scientific literature which explain hypoglycemic activity in plants. These include: Inhibition of the intestinal absorption of glucose; inhibition of alpha-glucosidase; and protection of the beta-pancreatic cells and of the liberated insulin. Also shown is the hypoglycemic activity of glycans. In a second section experimental results are presented with three plants widely used in Brazil as hypoglycemic agents: Myrcia multiflora (Lam.) D.C. (pedra-ume-caá); Punica granatum L. (roma, pomegranate); and Chrysobalanus icaco (abajeru). The experimental results show the activity of the plant extracts in the inhibition of the intestinal absorption of glucose.


Assuntos
Humanos , Diabetes Mellitus Tipo 2/tratamento farmacológico , Hipoglicemiantes/farmacocinética , Extratos Vegetais/farmacocinética , Polissacarídeos/farmacocinética , Trissacarídeos/farmacologia , Absorção Intestinal , alfa-Glucosidases/antagonistas & inibidores , Glucose/metabolismo , Hipoglicemiantes/farmacologia , Hipoglicemiantes/uso terapêutico , Extratos Vegetais/uso terapêutico
3.
Mem. Inst. Oswaldo Cruz ; 86(suppl. 2, n.esp): 203-5, Oct. 1991. tab
Artigo em Inglês | LILACS | ID: lil-127857

RESUMO

We have observed that several plants used popularly as anti-snake venom show anti-inflammatory activity. From the list prepared by Rizzini, Mors and Pereira some species have been selected and tested for analgesic activity (number of contortions) and anti-inflammatory activity (Evans blue dye diffusion - 1 per cents solution) according to Whittle's technique (intraperitoneal administration of 0.1 N-acetic acid 0.1 ml/10 g) in mice. Previous oral administration of a 10 per cents infusion (dry plant) or 20 per cents (fresh plant) corresponding to 1 or 2 g/Kg of Apuleia leiocarpa, Casearia sylvestris, Brunfelsia uniflora, Chiococca brachiata, Cynara scolymus, Dorstenia brasiliensis, Elephantopus scaber, Marsypianthes chamaedrys, Mikania glomerata and Trianosperma tayuya demonstrated analgesic and/or anti-inflammatory activities of varied intensity


Assuntos
Animais , Masculino , Feminino , Camundongos , Analgésicos/uso terapêutico , Anti-Inflamatórios/uso terapêutico , Plantas Medicinais , Mordeduras de Serpentes/tratamento farmacológico , Analgésicos/isolamento & purificação , Anti-Inflamatórios/isolamento & purificação , Brasil , Extratos Vegetais/uso terapêutico , Avaliação Pré-Clínica de Medicamentos
4.
Mem. Inst. Oswaldo Cruz ; 86(supl.2): 203-205, 1991. tab
Artigo em Inglês | LILACS | ID: lil-623971

RESUMO

We have observed that several plants used popularly as anti-snake venom show anti-inflammatory activity. From the list prepared by Rizzini, Mors and Pereira some species have been selected and tested for analgesic activity (number of contortions) and anti-inflammatory activity (Evans blue dye diffusion - 1% solution) according to Whittle's technique (intraperitoneal administration of 0.1 N-acetic acid 0.1 ml/10 g) in mice. Previous oral administration of a 10% infusion (dry plant) or 20% (fresh plant) corresponding to 1 or 2 g/Kg of Apuleia leiocarpa, Casearia sylvestris, Brunfelsia uniflora, Chiococca brachiata, Cynara scolymus, Dorstenia brasiliensis, Elephantopus scaber, Marsypianthes chamaedrys, Mikania glomerata and Trianosperma tayuya demonstrated analgesic and/or anti-inflammatory activities of varied intensity .


Assuntos
Soros Imunes , Medicina Tradicional/métodos
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