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1.
Indian J Exp Biol ; 1995 Dec; 33(12): 977-9
Artigo em Inglês | IMSEAR | ID: sea-61182

RESUMO

Tamoxifen given for breast cancer therapy, has a complex and an unclear action on the endometrium. A large number of literatures has attributed the proliferous changes in the endometrium caused by tamoxifen (Tam). No report has appeared on the endometrial cellular changes induced by Tam. The present study shows a significant (P < 0.001) increase in the proliferative activity due to Tam in endometrial stromal cells over control and estradiol (E2). This in vitro model is useful for the study of the hyperplasic effect of Tam at the cellular level.


Assuntos
Divisão Celular/efeitos dos fármacos , Hiperplasia Endometrial/induzido quimicamente , Endométrio/efeitos dos fármacos , Estudos de Avaliação como Assunto , Feminino , Humanos , Modelos Biológicos , Células Estromais/efeitos dos fármacos , Tamoxifeno/farmacologia
2.
Indian J Exp Biol ; 1995 Nov; 33(11): 861-4
Artigo em Inglês | IMSEAR | ID: sea-58454

RESUMO

Diuretic, hypotensive and hypoglycaemic effects of Phyllanthus amarus (syn. Phyllanthus niruri) on human subjects were assessed. Nine mild hypertensives (four of them also suffering from diabetes mellitus) were treated with a preparation of the whole plant of P. amarus for 10 days. Suitable parameters were studied in the blood and urine samples of the subjects, along with physiological profile and dietary pattern before and after the treatment period. Significant increase in 24 hr urine volume, urine and serum Na levels was observed. A significant reduction in systolic blood pressure in non-diabetic hypertensives and female subjects was noted. Blood glucose was also significantly reduced in the treated group. Clinical observations revealed no harmful side effects. These observations indicate that P. amarus is a potential diuretic, hypotensive and hypoglycaemic drug for humans.


Assuntos
Adulto , Anti-Hipertensivos/isolamento & purificação , Diabetes Mellitus/tratamento farmacológico , Diuréticos/isolamento & purificação , Feminino , Humanos , Hipertensão/tratamento farmacológico , Hipoglicemiantes/isolamento & purificação , Masculino , Pessoa de Meia-Idade , Plantas Medicinais
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