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Braz. oral res. (Online) ; 34: e038, 2020. tab, graf
Artigo em Inglês | LILACS, BBO | ID: biblio-1100932

RESUMO

Abstract The possible role of B-cell growth and differentiation-related cytokines on the pathogenesis of diabetes-related periodontitis has not been addressed so far. The aim of this study was to evaluate the effects of diabetes mellitus (DM) on the gene expression of proliferation-inducing ligand (APRIL) and B-lymphocyte stimulator (BLyS), two major cytokines associated to survival, differentiation and maturation of B cells in biopsies from gingival tissue with periodontitis. Gingival biopsies were obtained from subjects with periodontitis (n = 17), with periodontitis and DM (n = 19) as well as from periodontally and systemically healthy controls (n = 10). Gene expressions for APRIL, BLyS, RANKL, OPG, TRAP and DC-STAMP were evaluated using qPCR. The expressions APRIL, BLyS, RANKL, OPG, TRAP and DC-STAMP were all higher in both periodontitis groups when compared to the control group (p < 0.05). Furthermore, the expressions of BLyS, TRAP and RANKL were significantly higher in the subjects with periodontitis and DM when compared to those with periodontitis alone (p < 0.05). The mRNA levels of BLyS correlated positively with RANKL in the subjects with periodontitis and DM (p < 0.05). BLyS is overexpressed in periodontitis tissues of subjects with type 2 DM, suggesting a possible role of this cytokine on the pathogenesis DM-related periodontitis.


Assuntos
Humanos , Masculino , Feminino , Adulto , Idoso , Periodontite/imunologia , Periodontite/patologia , Diabetes Mellitus Tipo 2/complicações , Fator Ativador de Células B/análise , Osteogênese/imunologia , Valores de Referência , Biópsia , RNA Mensageiro/análise , Biomarcadores/análise , Estudos de Casos e Controles , Expressão Gênica , Citocinas/análise , Citocinas/fisiologia , Estatísticas não Paramétricas , Diabetes Mellitus Tipo 2/imunologia , Membro 13 da Superfamília de Ligantes de Fatores de Necrose Tumoral/análise , Reação em Cadeia da Polimerase em Tempo Real , Gengiva/imunologia , Gengiva/patologia , Pessoa de Meia-Idade
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