Study on effects of trinitrozotoluen on the cytochrome P450 enzyme system on Vietnamese

The content and the activity of the cytP450 system, peroxydase activity, free SH group in blood of patient intoxicated with trinitrotoluene (TNT) exposure was determined. Results showed that after its invasion into blood, a majority of trinitrotoluene was metabolized and excreted through urine, and deposited partly in organ tissues especially in bone marrow, liver, kidney, fatty and nervous tissues. Aniline hydrolase activity and Cyt P450 content enhanced, peroxydase acitivty, Cyt b5 and free SH group in TNT exposed patients decreased in comparing with healthy subjects. Therefore, it's necessary to strengthen the health of the subjects regularly exposed to TNT