Study on clinical significance of expression of p16,nm23 and PTEN gene in malignant tumors of biliary system / 中国普通外科杂志

Objective To study the clinical significance of the gene protein expression of p16,nm23 and PTEN in bile duct carcinoma.Methods The expression of p16,PTEN and nm23 gene protein in tissues of 63 cases of malignant tumors of biliary system(33 cases of bile duct carcinoma,30 cases of carcinoma of gallbladder) and 20 cases of benign bile duct lesion were studied by SP immunohistochemical technique and analyzed together with clinicopathologic data.Results The positive expression of p16,PTEN and nm23 in bile duct carcinoma tissue was low to medium,their expression rate was 36.5%,38.1% and 23.8%,(respectively),and was significantly lower than that of bile duct benign lesions(P

The Study of Silver-Binding Nucleolar Organizer Region(Ag NOR) in Benign and malignant Breast Lesions / 昆明医科大学学报

127 cases of benign and malignant breast lesions were observed with silver-binding method of nucleolar organizer region(Ag NOR).The results showed that there is obvious dif- ferenee of Ag NOR counts in nuclei of cells beween benign and malignant lesions and the dis- tributions,sizes and forms of the AgNOR in infiltrating ductal carcinoma and scirrhus among malignant tumors of breast.The higher malignant degree,The more amount of AgNOR the tumor cell has,and The higher proliferation the tumor cell has.This method is useful as a ma- jor assistant criterion to differentiate malignant and benign tumor and to sort the type of breast tumor.