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ABSTRACT Objective: This study investigates the relationship between serum nitric oxide, asymmetrical dimethylarginine and symmetrical dimethylarginine levels and Total Antioxidant Capacity, and cognitive function in patients with bipolar disorder. Method: The study included 42 bipolar patients, diagnosed and assessed according to the DSM-V criteria, and 30 healthy controls. The Sociodemographic Questionnaire was used for the collection of data, and a bivariate Pearson correlation analysis was carried out. Results: The patient scores from a Rey Auditory Verbal Learning Test (RAVLT), Auditory Consonant Trigram (ACT), Digit Span Test (DST), Wisconsin Card Sorting Test (WCST), Trail Making-B (TMT-B) and Stroop Tests (ST) were found to be impaired in patients with BD when compared to the healthy controls. The SDMA level of the patient group was significantly higher in the control group, while the ADMA level was lower. The SDMA value was found to be positively correlated with ST-1,2,5 duration; and the NO value was positively correlated with ST-3 duration. Conclusions: The presence of neurobiological markers may serve to predict the severity of neurocognitive deficits, and can provide information about the progress of the disease.
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Objective: Although several biomarkers have been evaluated for the diagnosis and prognosis of sepsis, the gold standard biomarker has not yet been found. We aimed to evaluate the diagnostic value of neutrophilto- lymphocyte count ratio [NLCR], neopterin, pro-adrenomedullin [pro-ADM] and the other infection markers to predict bacteremia in patients with SIRS, sepsis and severe sepsis/septic shock
Methods: A prospective cohort study was conducted on septic patients in a tertiary referral hospital between December 2014- July 2015. A total of 156 patients diagnosed with SIRS, sepsis and severe sepsis/ septic shock in Anesthesia intensive care unit [ICU] were included in the study
Results: A total of 156 patients who had been diagnosed as SIRS[10.9%], sepsis [44.2%] and severe sepsis/septic shock [44.9%] were included. Positive blood cultures were obtained in 64 patients. NLCR, neopterin and pro-ADM levels were insignificant in predicting bacteremia [p>0.05]. The mortality rate was significantly higher in bacteremic sepsis [43.9%] compared to non-bacteremic patients [20.8%] [p=0.001]. Only procalcitonin levels were significant predictor of mortality [p<0.001]
Conclusion: NLCR, CRP, procalcitonin, neopterin and pro-ADM levels were insignificant in diagnosis of bacteremia in critically ill patients. The gold standard method in predicting bacteremia is still blood culture positivity
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Fournier's gangrene [FG] is a life-threatening, rapidly progressing acute necrotizing fasciitis of perianal, genitourinary and perineal areas. The most common isolated pathogens are E.coli, Streptococcus and Enterococcus in tissue and abscess cultures. However we present the first Rhizobium radiobacter FG in this case. A 47-year-old man presented with black necrotizing area with malodorous pus drainage in the bottom of the right hemiscrotum. Intravenous imipenem and Clindamycin were started prophylactically; all necrotizing tissues were debrided and right hemiscrotectomy was performed. Rhizobium radiobacter was isolated from tissue and abscess cultures. After successful treatment patient was discharged posteroperative 18th day. The combination therapy of early and totally surgical debridement of necrotic tissues and appropriate antibiotic use are adequate to control Rhizobium radiobacter infection in FG