Correlation between early renal function injury in chronic kidney disease and metabolic syndrome in elderly healthy people / 中华老年医学杂志

Objective:To explore the correlation between metabolic syndrome(MS)and early renal function injury in chronic kidney disease(CKD)in the healthy elderly subjects having passed through a healthy physical examination.Methods:These healthy elderly subjects aged ≥ 60 years in the Sichuan Provincial People's Hospital health management center from September 2017 to August 2018 were randomly selected to collect lifestyle information such as disease history and living habits, as well as health information such as height, weight, waist circumference, blood pressure, fasting blood lipid, blood glucose, creatinine, morning urine routine, urinary protein and urinary occult blood.The detection situation of MS and early renal function injury of chronic kidney disease, and the correlation of MS and its abnormal components with early renal function injury of CKD were analyzed.Results:A total of 2 975 subjects, aged from 60 to 92 years old, with mean age of(67.10±5.98)years old, were enrolled.The detection rate of MS and early renal function impairment in CKD was 32.34%(962/2 975)and 28.84%(858/2 975)respectively.The detection rate of early CKD renal function injury in MS patients was 37.63%(362/962), which was higher than that in non-MS patients(24.64%)(496/2 013)( χ2=53.52, P<0.001). The prevalences of CKD and albumin/creatinine ratio(ACR)in MS patients were significantly higher than those in non-MS patients[31.91%(307/962)versus 17.49%(352/2 013)]with the difference being statistically significant( χ2=78.56, P <0.001). Central obesity, elevated blood pressure and elevated blood glucose increased the risk of CKD( OR=1.44, 1.82 and 1.74 respectively, all P< 0.05). Along with the increase of number of metabolic abnormal components, the risk of CKD increased. Conclusions:MS is a risk factor for early renal function impairment in CKD.Early control and treatment of MS are of great significance in reducing the incidence rate of CKD and delaying CKD progression.

Analysis of health check-up results for male adults from high altitude areas at a health check-up center in chengdu / 中华健康管理学杂志

Objective:To analyze the health screening results for adult men from high altitude areas in a Chengdu health screening center at high altitudes.Methods:The medical and physical examination results of 1 333 plateau people in Sichuan province people′s hospital health physical examination data management center who participated from 2014—2019 and aged 18-80 years old were analyzed. The general data of different age groups were compared using ANOVA analysis. The two groups were compared by independent sample t-test and Mann-Whitney U test, and χ 2 test was used to compare physical examination abnormalities among different age groups. Results:This population was generally overweight and obese, compared to the control group, with systolic blood pressure [(125.29±14.97) vs (123.52±14.87) mmHg(1 mmHg=0.133 kPa), height (168.64±6.26) vs (169.31±6.26) cm, weight (79.47±13.69) vs (71.02±10.62) kg, body mass index (27.91±4.45) vs (24.75±3.24) kg/m2, haemoglobin (169.03±15.18) vs (157.50±11.52) g/L, uric acid (393.12±75.48) vs (410.42±82.14) μmol/L, triacylglycerols 1.18(0.90, 1.69) vs 1.64(1.12, 2.37) mmol/L, total cholesterol 4.58(4.02, 5.15) vs 4.82(4.33, 5.36) mmol/L, HDL cholesterol 1.28(1.14, 1.46) vs 1.26(1.08, 1.46) mmol/L, LDL cholesterol 2.91(2.41, 3.42) vs 3.03(2.49, 3.60) mmol/L] levels were statistically significant (all P<0.05). The physical examination abnormalities detected were fatty liver, hyperlipidemia, abnormal liver function, hyperuricemia, elevated blood glucose, elevated blood pressure, gallbladder disease, abnormal kidney function, prostate hyperplasia, and erythrocytosis. The differences in the detection rates of the above abnormalities were statistically significant when compared between different age groups. Conclusion:The health status of the adult population from high altitude areas screened in our center is critical; therefore, appropriate health interventions need to be made.

Correlation of body weight and its change with albuminuria in physical examination population / 中华肾脏病杂志

Objective:To study the effect of baseline weight and its change on new-onset albuminuria or increased urine albumin/creatinine ratio (ACR) in the physical examination population.Methods:The subjects of this study were those who completed two or more physical examinations at the Physical Examination Center of Sichuan Provincial People's Hospital from September 1, 2013 to September 1, 2018. The general information and laboratory examination results at the first and last physical examinations were collected. According to body mass index (BMI), they were divided into normal BMI group and overweight/obese group. The differences in general clinical data and laboratory test results between the two groups were compared. The primary endpoint events were new-onset albuminuria or urine ACR increase≥30%. Stepwise multiple linear regression method was used to analyze the influencing factors for ACR increase, and Cox proportional hazard model method was used to analyze the impact of baseline weight and its change on new-onset albuminuria or ACR increase ≥30%.Results:A total of 1 761 physical examination subjects were included in this study. The follow-up time was (16.54±7.87) months. There were 59 patients with new-onset albuminuria, 30 patients with ACR increase≥30%, and 35 patients with albuminuria reversal. Multiple linear regression analysis showed that BMI was an independent influencing factor for ACR ( β=0.127, P<0.001). Cox regression analysis showed that the older age ( HR=1.041, 95% CI 1.018-1.064, P<0.001), hypertension ( HR=2.035, 95% CI 1.278-3.242, P=0.003), diabetes ( HR=2.081, 95% CI 1.310-3.305, P=0.002) and hyperuricemia ( HR=1.700, 95% CI 1.084-2.668, P=0.021) were independent influencing factors for new-onset albuminuria or ACR increase≥30%, while BMI ( HR=1.053, 95% CI 0.975-1.137, P=0.191) and weight change rate ( HR=1.030, 95% CI 0.972-1.092, P=0.322) were not independent influencing factors for endpoint events. Subgroup analysis indicated that overweight/obesity had interactions with age, hypertension, diabetes, and hyperuricemia, respectively ( P for interaction<0.05), and the effects of overweight/obesity on the pre-set primary endpoint events in each subgroup were basically consistent. There were interactions between weight gain and hypertension and diabetes ( P for interaction<0.05). Weight gain increased the risk of the primary endpoint events of women ( HR=3.355, 95% CI 1.164-9.670, P=0.025), and the effects of overweight/obesity on the pre-set primary endpoint events of each subcomponent were basically the same (all P>0.05). The incidence of albuminuria reversal in the group with obvious weight loss was slightly higher than that in the group with obvious weight gain, but the difference was not statistically significant ( P>0.05), which might be related to the small weight loss range (-6.08%±3.51%). Conclusions:Overweight or obesity may increase the risk of albuminuria, and people with diabetes, hypertension, and hyperuricemia may be more likely to occur. Mild weight loss is not enough to reverse albuminuria.

A control study of gonadal hormone level in female patients with panic disorder / 重庆医学

Objective To understand the serum gonadal hormone level of female patients with panic disorder(PD),and to analyze its relationship with the disease severity.Methods The chemiluminescence method was adopted to detect serum gonadal hormone level in 57 female patients with panic disorder and 74 healthy subjects,the panic disorder severity scale (PDSS),Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD) were simultaneously used to conduct the investigation.Results The serum pituitary prolactin (PRL) level in the female patients with PD had lower level was higher than that in the control group,the difference was statistically significant (P＜0.05);the luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels were lower than those in the control group(P＜0.05).The difference of the serum testosterone,estradiol and progesterone levels between the female patients with panic disorder and control group was not statistically significant (P＞0.05).The correlation analysis found that serum T level in the female patients with PD was negatively correlated with the disease severity of panic disorder,HAMD total score,retardation factor and sleep disorder factor (P＜0.05).Serum LH and FSH were positively correlated with the anxiety somatic factor of HAMA (P＜0.05).Serum FSH level was positively correlated with anxiety somatization and the sleep disorder factor of HAMD (P＜0.05).Conclusion The disorder of gonadal hormone levels may exist in the female patients with PD,and the serum T level is correlated with the PD severity and depressive symptoms.

Expressions of HER2 and Topo IIα in breast cancer and its clinical significance / 中南大学学报(医学版)

To detect the expressions of human epidermal growth factor receptor 2 (HER2) and Topo IIα in breast cancer, and to analyze the clinical significance of neoadjuvant chemotherapy for the anthracycline-based drugs.
 Methods: The HER2 and Topo IIα gene and protein expressions in cancer tissues from 189 patients with breast cancer were detected by fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC). And the objective response rate (ORR) and pathological complete rate (pCR) were analyzed.
 Results: The HER2 protein expression in 46 patients (24.3%) and Topo IIα protein expression in 55 patients (29.1%) was 3+ by IHC or they were 49 (25.9%) and 94 (49.0%) by FISH, respectively. The ORR and pCR in HER2 negative or positive patients were 47.4% and 20.3% or 32.7% and 16.3%, respectively, with significant differences (All P<0.05). The ORR and pCR in Topo IIα positive or negative patients were 69.1% and 36.0% or 28.4% and 2.2%, respectively, with significant differences (All P<0.05).
 Conclusion: FISH and IHC were consistent in the determination of HER2 expression whereas they were inconsistent in the determination of Topo IIα expression. The amplification of Topo IIα can effectively improve the effect of the adjuvant treatment effect of the anthracyclines.

Relationship of gastrointestinal bleeding with neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in adult patients with Henoch-Sch(o)nlein purpura / 中华皮肤科杂志

Objective To explore the relationship of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with gastrointestinal bleeding in adult patients with Henoch-Sch(o)nlein purpura (HSP).Methods Laboratory data including routine blood test results,C-reactive protein (CRP) levels and erythrocyte sedimentation rate (ESR) were collected from 115 adult patients with HSP and 100 healthy controls,and retrospectively analyzed.NLR and PLR were calculated and compared.Logistic regression analysis was used to determine variables associated with gastrointestinal bleeding in adult patients with HSP,and the receiver operating characteristic (ROC) curve was drawn to estimate the predictive efficacy of these variables.Results NLR and PLR were both significantly higher in adult patients with HSP than in healthy controls (both P ＜ 0.05),and NLR,PLR and CRP levels were all significantly higher in adult HSP patients with gastrointestinal bleeding than in those without (all P ＜ 0.05).Logistic regression analysis showed that NLR was an independent risk factor for gastrointestinal bleeding in adult HSP patients (P ＜ 0.05).The ROC curve revealed that the optimal cut-off point of NLR for predicting gastrointestinal bleeding was 3.24 in adult patients with HSP,with the sensitivity and specificity being 85.1％ and 71.3％ respectively.Conclusions Both NLR and PLR evidently increase in adult patients with HSP,especially in those with gastrointestinal bleeding.NLR is a potential predictor for gastrointestinal bleeding in adult patients with HSP.

Analysis of awareness and knowledge about cervical cancer of women in Chengdu / 中国基层医药

Objective To assess the awareness and knowledge about cervical cancer,cervical cancer screen-ing and human papillomavirus(HPV)of women in Chengdu.Methods A total of 1 077 women aged 19 -71 years old were recruited and assessed in their awareness and knowledge about cervical cancer and its issues.The collection of data was based on the questionnaire items.Results The awareness rates of cervical cancer,cervical cancer screen-ing,and HPV were 71.1%,23.2%,16.0%,respectively.There were significant differences in the awareness and knowledge about cervical cancer,cervical cancer screening and HPV between different ages(χ2 =89.238,16.532, 20.182,all P 40 -50 years old)was highest,the awareness rates of cervical cancer,cervical cancer screening,and HPV were 81.3%,27.7%,20.2% respectively.There were significant differ-ences in the awareness and knowledge about cervical cancer,cervical cancer screening and HPV between different marital status(χ2 =60.899,20.853,16.255,all P <0.05).There were significant differences in the awareness and knowledge about cervical cancer,cervical cancer screening and HPV between different education levels (χ2 =228.026,42.648,32.495,all P <0.05 ).The awareness of people accepted university education was highest,the awareness rates of cervical cancer,cervical cancer screening,and HPV were 87.6%,30.9%,21.6% respectively. There were significant differences in the awareness and knowledge about cervical cancer,cervical cancer screening and HPV between different income levels(χ2 =21.604,8.124,9.224,all P <0.05).Conclusion This study demon-strates a very low level of knowledge about cervical cancer,cervical cancer screening and HPV of women in Chengdu. In order to reduce the incidence rate and mortality of cervical cancer in Chengdu,it is strongly needed to make exten-sive health education to raise awareness of cervical cancer and HPV.

Investigation on chronic disease-related lifestyle and behavior in adults in Chengdu / 中华流行病学杂志

Objective To investigate the chronic disease related lifestyle and behavior in adults in Chengdu.Methods 8 324 residents (more than 18 years old) were investigated through random selection and stratified multi-stage cluster sampling method in Chengdu.Distributions on chronic diseases and relevant factors between chronic diseases and lifestyle/behavior were analyzed.Results 1 329 cases were suffered from chronic diseases,with prevalence rate as 16.0％.Smoking,passive smoking,irregular diet,intake smoked or pickled food,hardcore diet and lack of physical exercises were factors significantly related to the prevalence rates on chronic diseases (P＜0.05).Irregular diet,intake smoked and pickled food,hardcore diet and lack of physical exercise belonged to independent risk factors for chronic diseases in adults (P＜0.05).Conclusion The overall prevalence rate of chronic disease was high in adults in Chengdu.The related risk factors were closely related to lifestyle or behavior of the population that called for the development of programs on healthy life style and good habits.

Effect of blood lipid on the change of brachial-ankle pulse wave velocity among prehypertensive population / 中华流行病学杂志

<p><b>OBJECTIVE</b>To explore the effect of blood lipid and lipoprotein ratios on the change of brachial-ankle pulse wave velocity (baPWV) among prehypertensive subjects.</p><p><b>METHODS</b>11 611 subjects with normal blood pressure (BP) were divided into two groups, which was one with optimal blood pressure (BP<120/80 mmHg) and the other with prehypertension (BP:120-139/80-89 mmHg). Height, weight, baPWV, fasting blood-glucose, TC, TG, LDL-C and HDL-C were detected.</p><p><b>RESULTS</b>The abnormal rate of baPWV in prehypertension group was obviously higher than that in the optimal blood pressure group. For optimal blood pressure group, the abnormality of TG, TC, LDL-C, TC/HDL-C as well as LDL-C/HDL-C, caused the increase of baPWV significantly (P < 0.001). For prehypertensive group, the abnormality of TC and LDL-C caused the significant increase of baPWV (P < 0.001). Results from logistic regression analysis showed that except for age, BMI and fasting blood-glucose, TC/HDL-C increasing was the independent risk factor in optimal blood pressure group, while TG increasing was for the prehypertension group.</p><p><b>CONCLUSION</b>With different normal BP level, both abnormality of blood lipid and lipoprotein ratio were the independent risk factors for baPWV increasing.</p>

Characteristics of brachial-ankle pulse wave velocity and its relationship with risk factors of cardiovascular diseases in populations having health check-up programs / 中华流行病学杂志

<p><b>OBJECTIVE</b>To investigate the characteristics of brachial-ankle pulse wave velocity (baPWV)in populations having health check-up and to explore its relationship with risk factors of cardiovascular diseases.</p><p><b>METHODS</b>13 841 people who had health check-up were included and their baPWV were tested by automatic arteriosclerosis measurement system. All people were inquired about their diseases history, while height, weight, body mass index(BMI), blood pressure, fasting blood-glucose as well as serum lipid were also measured.</p><p><b>RESULTS</b>With increasing of age, baPWV were increased both in males and females. The baPWV of male aged less than 60 years was significantly higher than that of female less than 60. Multi-variable regressive analysis showed the age, systolic pressure,BMI, fasting blood-glucose, uric acid and triglyceride were the risk factors of baPWV.</p><p><b>CONCLUSION</b>BaPWV values of health check-up population in Chengdu area demonstrated different characteristics in different age and gender group. Attention should be paid on baPWV measurement among elder people, especially the elder women, in order to prevent cardiovascular events happening in high risk population.</p>

Prevalence of food intolerance and its related factors among health check-up receivers / 中华健康管理学杂志

Objective To study the prevalence of food intolerance and to explore its related factors among adult health check-up receivers.Methods A total of 863 adults who took physical examinations in our hospital from April to October 2011 were enrolled in this investigation.Height,body weight and blood pressure were measured,and serum IgG level was measured by enzyme-linked immunosorbent assay (ELISA).Results The total positive rate of food intolerance was 73％,and the leading intolerance items were crab (40.1％ ),egg (29.8％ ),cod fish ( 21.6％ ),milk ( 20.0％ ) and soybean ( 14.4％ ).Females showed significantly higher prevalence of food intolerance than males.Various positive rate of milk or soybean intolerance was found in different age groups.No correlations of serum specific IgG with body mass index and systolic or diastolic blood pressure were observed.In logistic regression analysis,the odds ratio of food intolerance of women was 1.67 ( 95 ％ confidence interval 1.190 to 2.607 ).ConclusionsThe prevalence rate of food intolerance was high.The risk for food intolerance was significantly increased in women.Specific IgG antibody detection may help to early prevent and diagnose food intolerance-related diseases.

Study on risk factors of hypertension among male bus drivers in Chongqing / 重庆医科大学学报

Objective:To investigate the incidence of hypertension and its risk factors among male bus drivers.Methods:A total of 512 male bus drivers in Chongqing were surveyed.Blood pressure,weight and height were examined.Result:The incidence of hypertension among male bus drivers was 23.63%,which was higher than that in general people.The age,family hypertension history and BMI were the main risk factors.Their OR were 2.014,2.490 and 3.530,respectively.Conclusion:Hypertension was the result of the interaction between inheritance and environment.Therefore,the strategy to prevent and control hypertension among bus drivers should be comprehensive.