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1.
China Journal of Orthopaedics and Traumatology ; (12): 92-96, 2019.
Artigo em Chinês | WPRIM | ID: wpr-776131

RESUMO

As an important component of articular cartilage, type IX collagen plays an important role in regulating homeostasis of bone and cartilage. The mutation or deletion of gene could disequilibrate homeostasis leads to deformity of corresponding bone and joint, and finally causes multiple epiphyseal dysplasia. Moreover, anatomic variation also leads to biomechanics change of corresponding functional unit, combine with micro-environment change caused by change of genes, osteoarthritis and disc degeneration were occurred under the function of stress over and over again. In addition, lack of type IX collagen could effect repair of articular cartilage, intervertebral disc tissue injury. However, musculoskeletal diseases related with type IX collagen has so much not limited this, the reports about it is less for lack of evidence, and need further work to study. Clear relationship of type IX collagen and its disease could provide an effective diagnostic method, and develop a new pathway for follow-up treatment.


Assuntos
Humanos , Cartilagem Articular , Colágeno , Colágeno Tipo IX , Degeneração do Disco Intervertebral , Doenças Musculoesqueléticas
2.
China Journal of Chinese Materia Medica ; (24): 1255-1259, 2014.
Artigo em Chinês | WPRIM | ID: wpr-321328

RESUMO

<p><b>OBJECTIVE</b>To discuss the intervention effect of ligustrazine on ox-LDL-induced foam cells from the perspective of reverse cholesterol transport.</p><p><b>METHOD</b>RAW264.7 cultured in vitro was induced with 20 mg x L(-1) ox-LDL to establish the foam cell model, and intervened with ligustrazine. The lipid accumulation in cells was observed by the oil red O dyeing. The changes in total cholesterol and cholesterol ester in the cells were detected with the colorimetric method. The fluorescent quantitative PCR and Western blot were used to detect the mRNA expressions of PPARgamma, LXRalpha and ABCA1.</p><p><b>RESULT</b>Ligustrazine could reduce total cholesterol and cholesterol ester in foam cells, inhibit the lipid accumulation, and increase the mRNA and protein expressions of PPARgamma, LXRalpha and ABCA1.</p><p><b>CONCLUSION</b>Ligustrazine can promote the reverse cholesterol transport by increasing the gene expressions of PPARgamma, LXRalpha and ABCA1.</p>


Assuntos
Animais , Camundongos , Transportador 1 de Cassete de Ligação de ATP , Genética , Metabolismo , Transporte Biológico , Linhagem Celular , Colesterol , Metabolismo , Medicamentos de Ervas Chinesas , Farmacologia , Células Espumosas , Metabolismo , Expressão Gênica , PPAR gama , Genética , Metabolismo
3.
China Journal of Orthopaedics and Traumatology ; (12): 617-620, 2014.
Artigo em Chinês | WPRIM | ID: wpr-249304

RESUMO

Osteoarthritis (OA) is a complex chronic progressive disease attacked by biological and mechanical factors and a result from the anabolic and catabolic imbalance in chondrocyte, subchondral bone and extracellular matrix(ECM). Etiology and pathological of OA are not yet entirely clear. The degradation and destruction of collagen II caused by matrix metalloproteinase -13 (MMP-13) is considered the core factor in the occurrence and development of OA. The research of MMP-13 inhibitor provide ideas and methods for the treatment of OA. In this article,the role and determination of MMP-13 in OA and the development prospect of MMP-13 inhibitor in the treatment of OA research progress were reviewed.


Assuntos
Animais , Humanos , Colágeno , Metabolismo , Metaloproteinase 13 da Matriz , Fisiologia , Inibidores de Metaloproteinases de Matriz , Usos Terapêuticos , Osteoartrite , Tratamento Farmacológico
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