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1.
West China Journal of Stomatology ; (6): 293-299, 2021.
Artigo em Inglês | WPRIM | ID: wpr-878446

RESUMO

OBJECTIVES@#This study aimed to evaluate the application value of a modified retroauricular hairline incision and a sternocleidomastoid flap with an inferior pedicle in the resection of benign parotid gland tumors.@*METHODS@#Forty-eight patients with benign parotid gland tumors were retrospectively analyzed: 19 cases were included in the experimental group with an improved retroauricular hairline incision and a sternocleidomastoid flap with an inferior pedicle, and 29 cases were assigned in the control group with a modified facelift incision. Operation time, postoperative drainage, postoperative esthetic degree, and incidence of facial nerve paralysis, salivary fistula, and Frey's syndrome were compared.@*RESULTS@#After the esthetic procedure, the average score of the experimental group was higher than that of the control group, and the esthetic effect of the former was better than that of the latter (@*CONCLUSIONS@#The modified retroauricular hairline incision and sternocleidomastoid flap with an inferior pedicle can be applied to resect benign parotid gland tumors safely. It shows a better cosmetic effect and does not cause obvious postoperative complications. Therefore, it should be promoted for tumor treatments.


Assuntos
Humanos , Estética Dentária , Glândula Parótida/cirurgia , Neoplasias Parotídeas/cirurgia , Complicações Pós-Operatórias , Estudos Retrospectivos , Sudorese Gustativa
2.
West China Journal of Stomatology ; (6): 460-463, 2020.
Artigo em Chinês | WPRIM | ID: wpr-827513

RESUMO

Osteonecrosis of the jaw could occur after intake of bisphosphonate drugs, which are widely used to treat osteoporosis and bone metastasis of malignant tumors. This effect has aroused concern among dentists. In this paper, a case of bisphosphonate-related osteonecrosis caused by implant is reported, and the pathogenesis, diagnosis, prevention, and treatment of bisphosphonate drug-induced osteonecrosis are described through a literature review. The effects of bisphosphonate drug treatment on dental implants are also discussed.


Assuntos
Humanos , Osteonecrose da Arcada Osseodentária Associada a Difosfonatos , Conservadores da Densidade Óssea , Implantes Dentários , Difosfonatos , Osteoporose
3.
West China Journal of Stomatology ; (6): 79-82, 2011.
Artigo em Chinês | WPRIM | ID: wpr-350232

RESUMO

<p><b>OBJECTIVE</b>To study the expression and its relationship of murine double minute 2 (MDM2), P53 protein in oral leukoplakia and squamous cell carcinoma.</p><p><b>METHODS</b>Immunohistochemical assay was used to detect the expression of MDM2 and P53 proteins in 15 normal oral epithelium tissues, 24 cases of oral leukoplakias and 41 cases of oral squamous cell carcinomas.</p><p><b>RESULTS</b>There were no positive expression of MDM2 and P53 in normal mucosa. With significantly difference compared with the normal group (P < 0.05), the positive rates of MDM2 and P53 were 58.3%, 75.6% and 37.5%, 68.3% in oral leukoplakia and squamous cell carcinoma. MDM2-positive rate had no significant difference (P > 0.05), while P53-positive rate was significant difference (P < 0.05) compared with oral leukoplakia and oral squamous cell carcinoma. Two kinds of indicators for further correlation analysis showed that MDM2 and P53 protein showed a positive correlation relationship both in oral leukoplakia (P = 0.018) and oral squamous cell carcinoma (P = 0.000).</p><p><b>CONCLUSION</b>The expression of MDM2 in oral leukoplakia and oral squamous cell carcinoma suggests that this gene may play a significant role in the process of carcinogenesis of oral squamous cell carcinoma. The correlation of MDM2 and P53 expression indicates that both of them may play a synergistic role in the process of carcinogenesis of oral squamous cell carcinoma.</p>


Assuntos
Animais , Humanos , Camundongos , Carcinoma de Células Escamosas , Leucoplasia Oral , Neoplasias Bucais , Proteína Supressora de Tumor p53
4.
West China Journal of Stomatology ; (6): 439-442, 2010.
Artigo em Chinês | WPRIM | ID: wpr-350317

RESUMO

<p><b>OBJECTIVE</b>The purpose of this study was to examine the expression of human major histocompatibility complex-I at different degrees of dysplasia leukoplakia, and to investigate local immune status and discuss their associations with oral leukoplakia.</p><p><b>METHODS</b>The monoclonal antibody of MHC class I antigen was employed in this study. There were 55 oral leukoplakias, 31 primary oral squamous cell carcinomas and 28 histologically normal oral epithelia were detected for the presence of the MHC class I molecule by using immunohistochemistry method.</p><p><b>RESULTS</b>The MHC class I antigen expression of the severe dysplasia and oral squamous cell carcinoma was significantly lower than that of the normal epithelia (P < 0.05). But their expression did not show statistically difference between the normal epithelia and other groups of oral leukoplakia (P > 0.05).</p><p><b>CONCLUSION</b>The expression levels of the MHC class I antigen is reduced in oral leukoplakia, particularly in severe dysplasia oral leukoplakia, it is relevant to the degree of dysplasia.</p>


Assuntos
Humanos , Anticorpos Monoclonais , Carcinoma de Células Escamosas , Genética , Genes MHC Classe I , Antígenos de Histocompatibilidade Classe I , Genética , Imuno-Histoquímica , Leucoplasia Oral , Genética , Neoplasias Bucais , Genética
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