The 5-year survival rate of 11 958 postoperative non-small cell lung cancer patients in stage Ⅰ-ⅢA by two different follow-up patterns: A multi-center, real-world study / 中国胸心血管外科临床杂志

@#Objective    To compare the 5-year survival rates between two different follow-up patterns of postoperative stage Ⅰ-ⅢA non-small cell lung cancer (NSCLC) patients. Methods    Pathological stage Ⅰ-ⅢA NSCLC 11 958 patients who underwent surgical resection and received follow-up within 6 months after initial diagnosis through telephone follow-up system were included in nine hospitals from July 2014 to July 2020. The patients were divided into two groups including a proactive follow-up group (n=3 825) and a passive follow-up group (n=8 133) according to the way of following-up. There were 6 939 males and 5 019 females aged 59.8±9.5 years. The Kaplan-Meier and Cox proportional hazards regression model were used. Results    The median follow-up frequency was 8.0 times in the proactive follow-up group and 7.0 times in the passive follow-up group. The median call duration was 3.77 minutes in the proactive follow-up group and 3.58 minutes in the passive follow-up group. The 5-year survival rate was 81.8% and 74.2% (HR=0.60, 95CI 0.53-0.67, P<0.001) in the proactive follow-up group and the passive follow-up group, respectively. Multivariate analysis showed that follow-up pattern, age, gender and operation mode were independent prognostic factors, and the results were consistent in all subgroups stratified by clinical stages. Conclusion    The proactive follow-up leads to better overall survival for resected stage Ⅰ-ⅢA NSCLC patients, especially in the stage ⅢA.

Key issues on the clinical trial data management / 药学学报

This paper is prepared to discuss the common issues in data management, such as building and training of data management team, standard operation procedure, document management, execution and communication, strategies to correct and prevent mistakes, and measures to improve the quality and efficiency of clinical trials and data management.

Infrastructure and contents of clinical data management plan / 药学学报

Establishment of quality management system (QMS) plays a critical role in the clinical data management (CDM). The objectives of CDM are to ensure the quality and integrity of the trial data. Thus, every stage or element that may impact the quality outcomes of clinical studies should be in the controlled manner, which is referred to the full life cycle of CDM associated with the data collection, handling and statistical analysis of trial data. Based on the QMS, this paper provides consensus on how to develop a compliant clinical data management plan (CDMP). According to the essential requirements of the CDM, the CDMP should encompass each process of data collection, data capture and cleaning, medical coding, data verification and reconciliation, database monitoring and management, external data transmission and integration, data documentation and data quality assurance and so on. Creating and following up data management plan in each designed data management steps, dynamically record systems used, actions taken, parties involved will build and confirm regulated data management processes, standard operational procedures and effective quality metrics in all data management activities. CDMP is one of most important data management documents that is the solid foundation for clinical data quality.

A bibliometrical analysis of academic status of Chinese core orthopaedic journals from 2005 to 2007 / 中华创伤骨科杂志

Objective To evaluate the academic status of 16 Chinese core orthopaedic journals from 2005 to 2007 in terms of general citation frequency, impact factors, allo-citation rate and specialty influence index. Methods On the basis of the normalized data published by Chinese S& T Journal Citation Reports (CJCR), the general citation frequency, impact factors, allo-citation rate and specialty influence index of the 16 Chinese core orthopaedic journals from 2005 to 2007 were ranked respectively and sta-tistically analyzed. Results In terms of the above 4 indicators, Chinese Journal of Orthopedics ranked the first, followed by Chinese Journal of Trauma and Chinese Journal of Reparative and Reconstructive Surgery. Considering its short history, our journal, Chinese Journal of Orthopedic Trauma, made a rapid progress in academic status. Conclusion Generally speaking, the 16 Chinese core orthopaedic journals enjoy a high academic quality and relatively significant impact.

Limiting behavior of delayed sums under a non-identically distribution setup

We present an accurate description the limiting behavior of delayed sums under a non-identically distribution setup, and deduce Chover-type laws of the iterated logarithm for them. These complement and extend the results of Vasudeva and Divanji (Theory of Probability and its Applications, 37 (1992), 534-542).

Apresentamos uma descrição precisa do comportamento limite de somas retardadas, e deduzimos leis do tipo Chover de logaritmo iterado para as mesmas. Isso completa e estende os resultados de Vasudeva e Divanji (Theory of Probability and its Aplications, 37 (1992), 534-542).

Analysis of variance of repeated measure data / 中华创伤骨科杂志

Sometimes results are expressed by repeated measure data in the field of medical research. Inappropriate statistical methods were widely used in the national medical literature. For instance, two way ANOVA or single effect analysis were usually used to analyze this kind of data. This paper introduces the repeated measure ANOVA. For repeated measure data, how to apply the SPSS 10.0 to conduct data analysis and how to report the statistically analyzed results correctly in the medical literature are also answered here.

Development of electronic inpatient satisfaction questionnaires / 中华医院管理杂志

Objective To develop electronic touch-screen inpatient satisfaction questionnaires so as to improve the real-fimeness and accuracy of data processing in patient satisfaction surveys and evaluations. Methods 266 inpatients from 20 clinical departments of a certain hospital in Zhangjiakou were asked to make satisfaction evaluations via a touch screen and the reliability and validity of the questionnaires were assessed by statistical and psychological means. Results The item response rate was 98.72％, the effective rate was 98.1％, and the a reliability coefficient for internal consistency was 0.9474; the composition of the questionnaires, which matched the reality of management, supported contents validity; a factor analysis showed that the factor load and structure, which matched the structure of the questionnaires, supported structure validity; intra-factor correlations, which were stronger than interfactor correlations, supported aggregation and discrimination validity. Conclusion The questionnaires, reliable andvalid, interface friendly and easy to operate, facilitate their use by patients with different backgrounds. The real-time occurrence and antomatic pooling of survey data render possible the automation of data collection in patient satisfaction surveys and evaluations.