RESUMO
Exosomes are a kind of extracellular vesicles, which contain abundant proteins, RNA, and lipids. They are source-specific and target-specific, and can penetrate the blood-brain barrier and used as biomarkers of diseases and drug carriers. Studies in recent years have shown that exosomes play an important role in the pathophysiology of ischemic stroke. During cerebral ischemia, endothelium-derived exosomes can cause damage to the blood-brain barrier, while exosomes secreted by astrocytes and oligodendrocytes have neuroprotective functions. The exosomes from mesenchymal stem cells can be engineered to promote post-stroke nerve repair and improve neurological deficits. This article reviews the research progress of the correlation between exosomes and ischemic stroke.