RESUMO
Objective: To determine the frequency of an increase in intraocular pressure [IOP] after intravitreal triamcinolone acetonide [IVTA] in diabetic versus non-diabetic patients with various chorio-retinal disorders
Methods: This prospective, interventional comparative case series was conducted at Isra Postgraduate Institute of Ophthalmology, Al-Ibrahim Eye Hospital, Karachi from May 2012 to April 2014. Two hundred thirty seven eyes of 180 patients were enrolled with 90 patients each in diabetic and non-diabetic group, requiring IVTA. IVTA 4mg/0.1ml was injected and IOP was measured at one week, one month, three months and six months in both groups of patients
Results: In diabetic group, 43 patients were male [47.8 percent] and 47 were female [52.2 percent], while in non-diabetic group, 56 [62.2 percent] patients were male and 34 [37.8 percent] were female. Mean age of patients in diabetic group was 52.21 +/- 9.6 years and in non-diabetic group was 51.13 +/- 10.75 years. The mean preoperative IOP was 13.6 +/- 2.8 mmHg and 14.1 +/- 2.4 mmHg in diabetic and non-diabetic group respectively. In diabetic group, mean [+/-SD] IOP was 16.4 +/-4.9 mmHg, 14.6 +/-3.6 mmHg, 17.6 +/- 9.7 mmHg and 15.5 +/- 7.09 mmHg at one week, one month, three months and 6 months post injection. While in non-diabetic cases, mean [+/-SD] IOP was 14.8 +/- 3.33 mmHg, 15.9 +/- 4.2 mmHg, 15.5 +/- 4.2 mmHg and 14.1 +/- 3.2 mmHg at one week, one month, three months and 6 months follow up. The raised IOP was observed in 117 eyes [49 percent] in both groups of patients, with 78 eyes [65 percent] in diabetic group and 39 eyes [33 percent] in non-diabetic group
Conclusion: After IVTA, an IOP rise was observed more in diabetics than non-diabetic patients