RESUMO
Primary progressive aphasia (PPA) is a progressive neurodegenerative disease that disrupts the language capacity of an individual by selectively affecting the language network of brain. Although aphasic literature is replete with reports of brain damage responsible for various types of PPA, it does not provide a comprehensive understanding of whether PPA is an independent pathological condition or an atypical syndrome of neurodegenerative diseases (NDD). To address this ambiguity, we provide a detailed description of PPA, its variants and their brain anatomy. Subsequently, we unravel the relationship between PPA and NDDs like Alzheimer’s, Parkinson’s and Dyslexia. To substantiate the relationship further, we also provide a brief account of their genetic aetiology. In the final section, we offer an exhaustive approach towards the treatment of PPA by combining the existing language the rapies with clinical and pharmacological interventions.
RESUMO
Associating human genetic makeup with the faculty of language has long been a goal for biolinguistics. This stimulated theidea that language is attributed to genes and language disabilities are caused by genetic mutations. However, application ofgenetic knowledge on language intervention is still a gap in the existing literature. In an effort to bridge this gap, this articlepresents an account of genetic and neural associations of language and synthesizes the genetic, neural, epigenetic andenvironmental facets involved in language. In addition to describing the association of genes with language, the neural andepigenetic aspects of language are also explored. Further, the environmental aspects of language such as language input,emotion and cognition are also traced back to gene expressions. Therefore, effective language intervention for languagelearning difficulties must offer genetics-informed solutions, both linguistic and medical.