RESUMO
One hundred two children (43 males and 59 females) aged 6 to 14 years with positive stool examination by Kato-Katz and/or Harada-Mori culture techniques for N. americanus, were randomly divided into two groups. Group I with 48 children were treated with a single dose albendazole, 400 mg. Group II, 54 children, received a single dose mebendazole, 600 mg. After treatment, repeated stool examination was performed on Day 14, Day 21 and Day 28. The children were considered cured when stool examination was negative on all three occasions by both methods. The cure rate was 64% in Group I and 11% in Group II. The difference was statistically significant (p less than 0.05). The eggs reduction rate was 98% in Group I and 95% in Group II. Mild and transient side effects such as nausea, dizziness and headache were observed in both groups. Albendazole, 400 mg, as a single dose treatment was shown to be superior to mebendazole, 600 mg, single dose for the mass treatment of hookworm infection, especially that of Necator americanus, in an endemic area.
Assuntos
Adolescente , Albendazol/administração & dosagem , Animais , Criança , Quimioterapia Combinada , Feminino , Humanos , Masculino , Mebendazol/administração & dosagem , Necator , Necatoríase/tratamento farmacológico , Ensaios Clínicos Controlados Aleatórios como AssuntoRESUMO
Fifty children aged 5 to 12 years whose fecal examination confirmed of strongyloidiasis were divided into 2 groups. One group (Group I) of 26 received 400 mg albendazole once a day for 3 consecutive days. The other group (Group II) of 24 received the same dosage but repeated a week later. Simple smear fecal examination was performed for 3 consecutive days before treatment, and stool cultures were performed on Days 13, 14, 15 21, 22 and 23 after treatment. Evaluation of successful treatment or cure was based on the absence of larvae in 6 culture specimens. The cure rates were 80.8% in Group I and 91.7% in Group II (p = 0.18). Side effect consisted of mild and transient vomiting in one patient in each group. Although the difference in cure rates between the two drug regimens was not statistically different, two courses of treatment (Group II) resulted in a higher cure rate.