RESUMO
Purpose: Hyperemesis gravidarum is one of the leading causes of hospitalization during pregnancy. This randomized study wasaimed to compare and evaluate the efficacy of granisetron and promethazine in controlling nausea and vomiting in pregnancy.Materials and Methods: This study was done in the Department of Obstetrics and Gynaecology, Nalanda Medical College andHospital, Patna, Bihar, over a period of 6 months from February 2019 to July 2019. The included patients were administeredgranisetron and promethazine randomly and evaluated for nausea and vomiting by senior gynecologist blinded to designated drugs.Results: This study showed that granisetron was more effective than promethazine in controlling nausea and vomiting inpregnant patients. Greater patient satisfaction and less adverse drug reaction were observed in women receiving granisetron.Conclusion: Hyperemesis gravidarum is a health-related problem with social, economic, and psychological dimensions.All efforts, especially simple outpatient strategies, can reduce the severity of this condition and will help pregnant women tocontinue her pregnancy with satisfaction.